scholarly journals Incorporating digital anorectal examinations for anal cancer screening into routine HIV care for men who have sex with men living with HIV: a prospective cohort study

2018 ◽  
Vol 21 (12) ◽  
pp. e25192 ◽  
Author(s):  
Jason J Ong ◽  
Sandra Walker ◽  
Andrew Grulich ◽  
Jennifer Hoy ◽  
Tim RH Read ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Screening ◽  
Prospective Cohort Study ◽  
Anal Cancer ◽  
Prospective Cohort ◽  
Hiv Care ◽  
Sex With Men ◽  
Anal Cancer Screening ◽  
Living With Hiv

scholarly journals mRNA Detection in Anal Cytology: A Feasible Approach for Anal Cancer Screening in Men Who Have Sex with Men Living With HIV

Diagnostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 173
Author(s):  
Pino ◽  
Martí ◽  
Gaber ◽  
Svanholm-Barrie ◽  
Rodríguez-Carunchio ◽  
...  
Keyword(s):  
Cancer Screening ◽  
Anal Cancer ◽  
Intraepithelial Neoplasia ◽  
Low Grade ◽  
Mrna Detection ◽  
Hpv Test ◽  
Screening Strategies ◽  
Sex With Men ◽  
Anal Cancer Screening ◽  
Living With Hiv

There is growing interest in anal cancer screening strategies. However, cytological/molecular evaluation of anal samples is challenging. We aimed to determine the feasibility of detecting, in anal liquid-based cytologies, the expression of biomarkers involved in the cell cycle disturbance elicited by human papillomavirus (HPV). The accuracy of this approach in the identification of high-grade squamous intraepithelial lesions/anal intraepithelial neoplasia grade2–3 (HSIL/AIN2–3) was also evaluated. 215 anal cytologies from men having sex with men living with human immunodeficiency virus were evaluated. Patients showing concordant cytological and anoscopy-directed biopsy diagnosis were selected: 70 with negative cytology and HPV test, 70 with low-grade SIL (LSIL/AIN1) cytology and biopsy, and 75 with cytology and biopsy of HSIL/AIN2–3. CDKN2A/p16, MKI67 and TOP2A mRNA expression was analyzed. HPV detection was performed with Xpert HPV Assay (Cepheid, Sunnyvale, CA, USA). HSIL/AIN2–3 showed higher expression for the biomarkers than LSIL/AIN1 or negative samples. The specificity for HSIL/AIN2–3 detection for a sensitivity established at 70% was 44.7% (95%confidence interval [CI] 36.5–53.2) for TOP2A and MKI67 and 54.5% (95%CI 46.0–62.8%) for CDKN2A/p16. mRNA detection of cell biomarkers in anal liquid-based cytology is feasible. Further studies are warranted to confirm if strategies based on mRNA detection have any role in anal cancer screening.

scholarly journals Corregendium to e21985 (Preprint)

2021 ◽  
Author(s):  
Patrick Sullivan ◽  
Jodie L Guest
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Full Text ◽  
Prospective Cohort ◽  
White Men ◽  
Pubmed Central ◽  
Black And White ◽  
Care Outcomes ◽  
Sex With Men ◽  
Living With Hiv

UNSTRUCTURED In “Disparities in Care Outcomes in Atlanta Between Black and White Men Who Have Sex With Men Living With HIV: Protocol for a Prospective Cohort Study (Engage[men]t)” (JMIR Res Protoc 2021;10(2):e21985) the authors noted one error. In the originally published manuscript, one author was inadvertently not displayed in the authorship list. Author Jodie Guest was uploaded in the manuscript file, but inadvertently not entered in the online metadata.. Dr. Guest’s authorship has been recognized in the corrected manuscript. The correction will appear in the online version of the paper on the JMIR Publications website on April 28, 2021, together with the publication of this correction notice. Because this was made after submission to PubMed, PubMed Central, and other full-text repositories, the corrected article has also been resubmitted to those repositories.

Factors associated with anal cancer screening uptake in men who have sex with men living with HIV

2020 ◽  
Vol 29 (1) ◽  
pp. 1-6
Author(s):  
Alexis Vanhaesebrouck ◽  
Simon Pernot ◽  
Juliette Pavie ◽  
Marie-Laure Lucas ◽  
Lio Collias ◽  
...  
Keyword(s):  
Cancer Screening ◽  
Anal Cancer ◽  
Factors Associated ◽  
Screening Uptake ◽  
Sex With Men ◽  
Anal Cancer Screening ◽  
Living With Hiv

scholarly journals Anal Cancer Screening in Men Who Have Sex With Men in the Multicenter AIDS Cohort Study

2016 ◽  
Vol 71 (5) ◽  
pp. 570-576 ◽  
Author(s):  
Gypsyamber DʼSouza ◽  
Alicia Wentz ◽  
Dorothy Wiley ◽  
Nisha Shah ◽  
Francine Barrington ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Screening ◽  
Anal Cancer ◽  
Multicenter Aids Cohort Study ◽  
Sex With Men ◽  
Anal Cancer Screening

scholarly journals Disparities in Care Outcomes in Atlanta Between Black and White Men Who Have Sex With Men Living With HIV: Protocol for a Prospective Cohort Study (Engage[men]t) (Preprint)

2020 ◽  
Author(s):  
Patrick Sean Sullivan ◽  
Jennifer Taussig ◽  
Mariah Valentine-Graves ◽  
Nicole Luisi ◽  
Carlos Del Rio ◽  
...  
Keyword(s):  
Cohort Study ◽  
Black Men ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Viral Suppression ◽  
White Men ◽  
Black And White ◽  
Care Outcomes ◽  
Sex With Men ◽  
Living With Hiv

BACKGROUND The US HIV epidemic is driven by infections in men who have sex with men and characterized by profound disparities in HIV prevalence and outcomes for Black Americans. Black men who have sex with men living with HIV are reported to have worse care outcomes than other men who have sex with men, but the reasons for these health inequities are not clear. We planned a prospective observational cohort study to help understand the reasons for worse HIV care outcomes for Black versus White men who have sex with men in Atlanta. OBJECTIVE The aim of this study is to identify individual, dyadic, network, neighborhood, and structural factors that explain disparities in HIV viral suppression between Black and White men who have sex with men living with HIV in Atlanta. METHODS Black and White men who have sex with men living with HIV were enrolled in a prospective cohort study with in-person visits and viral suppression assessments at baseline, 12 months, and 24 months; additional surveys of care and risk behaviors at 3, 6, and 18 months; analysis of care received outside the study through public health reporting; and qualitative interviews for participants who experienced sentinel health events (eg, loss of viral suppression) during the study. The study is based on the Bronfenbrenner socioecological theoretical model. RESULTS Men who have sex with men (n=400) were enrolled between June 2016 and June 2017 in Atlanta. Follow-up was completed in June 2019; final study retention was 80% at 24 months. CONCLUSIONS Health disparities for Black men who have sex with men are hypothesized to be driven by structural racism and barriers to care. Observational studies are important to document and quantify the specific factors within the socioecological framework that account for disparities in viral suppression. In the meantime, it is also critical to push for steps to improve access to care, including Medicaid expansion in Southern states, such as Georgia, which have not yet moved to expand Medicaid. CLINICALTRIAL INTERNATIONAL REGISTERED REPORT DERR1-10.2196/21985

scholarly journals Correction: Disparities in Care Outcomes in Atlanta Between Black and White Men Who Have Sex With Men Living With HIV: Protocol for a Prospective Cohort Study (Engage[men]t)

10.2196/30020 ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. e30020
Author(s):  
Patrick Sean Sullivan ◽  
Jennifer Taussig ◽  
Mariah Valentine-Graves ◽  
Nicole Luisi ◽  
Carlos Del Rio ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
White Men ◽  
Black And White ◽  
Care Outcomes ◽  
Sex With Men ◽  
Living With Hiv

mRNA Biomarker in Anal Cytology: A Feasible Approach for Anal Cancer Screening in Men Who Have Sex with Men Living with HIV

2019 ◽  
Author(s):  
Marta del Pino ◽  
Cristina Martí ◽  
Jina Gaber ◽  
Cecilia Svanholm-Barrie ◽  
Leonardo Rodríguez-Caruchio ◽  
...  
Keyword(s):  
Cancer Screening ◽  
Anal Cancer ◽  
Anal Cytology ◽  
Sex With Men ◽  
Anal Cancer Screening ◽  
Living With Hiv
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