Identification and determination of cystathionine sulfoxide and NAc-cystathionine sulfoxide in the urine of a patient with cystathioninuria using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

1995 ◽  
Vol 30 (9) ◽  
pp. 1296-1302 ◽  
Author(s):  
Jianying Zhang ◽  
Noriyoshi Masuoka ◽  
Toshihiko Ubuka ◽  
Hiroyuki Kodama
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Atmospheric Pressure ◽  
Chemical Ionization ◽  
Atmospheric Pressure Chemical Ionization ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Pressure Chemical Ionization ◽  
Pressure Chemical

Comparison of Liquid Chromatography–Atmospheric Pressure Chemical Ionization/Mass Spectrometry and Liquid Chromatography–Postcolumn Fluorometry for Determination of Carbamates in Food

1995 ◽  
Vol 78 (5) ◽  
pp. 1312-1316 ◽  
Author(s):  
W Harvey Newsome ◽  
Benjamin P-Y Lau ◽  
Dean Ducharme ◽  
David Lewis
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Atmospheric Pressure ◽  
Chemical Ionization ◽  
Atmospheric Pressure Chemical Ionization ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Pressure Chemical Ionization ◽  
Pressure Chemical

Abstract Two detection methods, postcolumn derivatization with fluorescent detection and atmospheric pressure chemical ionization/mass spectrometry (MS) were compared for determination of N-methyl carbamates in food by liquid chromatography. Five commodities were spiked with 11 carbamates at levels from 10 to 100 ppb, extracted, and cleaned up by using a method based on the AOAC official method. With each detection method, sample blanks showed false-positive responses, indicating that neither method alone provides definitive identification. Except for aldicarb sulfoxide determined by MS, recoveries were linear between 10 and 100 ppb. Agreement between the 2 methods was good for determination of recoveries at 25 ppb. Coefficients of variation were 11–33% for fluorescence detection and 9–26% for MS.

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