Determination of morphine and its 3- and 6-glucuronides, codeine, codeine-glucuronide and 6-monoacetylmorphine in body fluids by liquid chromatography atmospheric pressure chemical ionization mass spectrometry

1997 ◽  
Vol 703 (1-2) ◽  
pp. 115-127 ◽  
Author(s):  
Maciej J Bogusz ◽  
Rolf-Dieter Maier ◽  
Manfred Erkens ◽  
Sarah Driessen
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Atmospheric Pressure ◽  
Chemical Ionization ◽  
Atmospheric Pressure Chemical Ionization ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Pressure Chemical Ionization ◽  
Pressure Chemical

Comparison of Liquid Chromatography–Atmospheric Pressure Chemical Ionization/Mass Spectrometry and Liquid Chromatography–Postcolumn Fluorometry for Determination of Carbamates in Food

1995 ◽  
Vol 78 (5) ◽  
pp. 1312-1316 ◽  
Author(s):  
W Harvey Newsome ◽  
Benjamin P-Y Lau ◽  
Dean Ducharme ◽  
David Lewis
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Atmospheric Pressure ◽  
Chemical Ionization ◽  
Atmospheric Pressure Chemical Ionization ◽  
Chemical Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Pressure Chemical Ionization ◽  
Pressure Chemical

Abstract Two detection methods, postcolumn derivatization with fluorescent detection and atmospheric pressure chemical ionization/mass spectrometry (MS) were compared for determination of N-methyl carbamates in food by liquid chromatography. Five commodities were spiked with 11 carbamates at levels from 10 to 100 ppb, extracted, and cleaned up by using a method based on the AOAC official method. With each detection method, sample blanks showed false-positive responses, indicating that neither method alone provides definitive identification. Except for aldicarb sulfoxide determined by MS, recoveries were linear between 10 and 100 ppb. Agreement between the 2 methods was good for determination of recoveries at 25 ppb. Coefficients of variation were 11–33% for fluorescence detection and 9–26% for MS.

Sign in / Sign up

Export Citation Format

Share Document