scholarly journals Traumatic axonal injury: Relationships between lesions in the early phase and diffusion tensor imaging parameters in the chronic phase of traumatic brain injury

2016 ◽  
Vol 94 (7) ◽  
pp. 623-635 ◽  
Author(s):  
Kent Gøran Moen ◽  
Anne Vik ◽  
Alexander Olsen ◽  
Toril Skandsen ◽  
Asta Kristine Håberg ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Early Phase ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Chronic Phase ◽  
Traumatic Axonal Injury ◽  
Imaging Parameters ◽  
And Diffusion

scholarly journals Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury

2007 ◽  
Vol 205 (1) ◽  
pp. 116-131 ◽  
Author(s):  
C MACDONALD ◽  
K DIKRANIAN ◽  
S SONG ◽  
P BAYLY ◽  
D HOLTZMAN ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Mouse Model ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Traumatic Axonal Injury

The relation between cognitive dysfunction and diffusion tensor imaging parameters in traumatic brain injury

Brain Injury ◽  
2018 ◽  
Vol 33 (3) ◽  
pp. 355-363 ◽  
Author(s):  
Robin Hanks ◽  
Scott Millis ◽  
Selena Scott ◽  
Ramtilak Gattu ◽  
Nolan B. O’Hara ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Cognitive Dysfunction ◽  
Diffusion Tensor ◽  
Imaging Parameters ◽  
And Diffusion

170 Myelination and Diffusion Tensor Imaging Findings in Mild Traumatic Brain Injury

Neurosurgery ◽  
2013 ◽  
Vol 60 ◽  
pp. 176-177
Author(s):  
Heather Spader ◽  
Anna Ellermeier ◽  
Lindsay Walker ◽  
Jeffrey Rogg ◽  
Rees Cosgrove ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Diffusion Tensor ◽  
Imaging Findings ◽  
And Diffusion

scholarly journals Diffusion Tensor Imaging of the Evolving Response to Mild Traumatic Brain Injury in Rats

2019 ◽  
Vol 13 ◽  
pp. 117906951985862 ◽  
Author(s):  
Wouter S Hoogenboom ◽  
Todd G Rubin ◽  
Kenny Ye ◽  
Min-Hui Cui ◽  
Kelsey C Branch ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
White Matter ◽  
Mild Traumatic Brain Injury ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Mean Diffusivity ◽  
Multiple Time ◽  
Post Injury

Mild traumatic brain injury (mTBI), also known as concussion, is a serious public health challenge. Although most patients recover, a substantial minority suffers chronic disability. The mechanisms underlying mTBI-related detrimental effects remain poorly understood. Although animal models contribute valuable preclinical information and improve our understanding of the underlying mechanisms following mTBI, only few studies have used diffusion tensor imaging (DTI) to study the evolution of axonal injury following mTBI in rodents. It is known that DTI shows changes after human concussion and the role of delineating imaging findings in animals is therefore to facilitate understanding of related mechanisms. In this work, we used a rodent model of mTBI to investigate longitudinal indices of axonal injury. We present the results of 45 animals that received magnetic resonance imaging (MRI) at multiple time points over a 2-week period following concussive or sham injury yielding 109 serial observations. Overall, the evolution of DTI metrics following concussive or sham injury differed by group. Diffusion tensor imaging changes within the white matter were most noticeable 1 week following injury and returned to baseline values after 2 weeks. More specifically, we observed increased fractional anisotropy in combination with decreased radial diffusivity and mean diffusivity, in the absence of changes in axial diffusivity, within the white matter of the genu corpus callosum at 1 week post-injury. Our study shows that DTI can detect microstructural white matter changes in the absence of gross abnormalities as indicated by visual screening of anatomical MRI and hematoxylin and eosin (H&E)-stained sections in a clinically relevant animal model of mTBI. Whereas additional histopathologic characterization is required to better understand the neurobiological correlates of DTI measures, our findings highlight the evolving nature of the brain’s response to injury following concussion.

Prognostic Value of Diffusion Tensor Imaging Parameters in Severe Traumatic Brain Injury

2012 ◽  
Vol 29 (7) ◽  
pp. 1292-1305 ◽  
Author(s):  
Joshua Betz ◽  
Jiachen Zhuo ◽  
Anindya Roy ◽  
Kathirkamanthan Shanmuganathan ◽  
Rao P. Gullapalli
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Prognostic Value ◽  
Diffusion Tensor ◽  
Imaging Parameters

Analysis of Diffuse Axonal Injury Using Diffusion Tensor Imaging in Traumatic Brain Injury Patients

2010 ◽  
Vol 3 (2) ◽  
pp. 111
Author(s):  
Hyung Jong Choi ◽  
Jong-Gu Kang ◽  
Seung Ho Ahn ◽  
Suk Hoon Ohn ◽  
Kwang-Ik Jung ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Diffuse Axonal Injury

scholarly journals Neuropsychological Outcome and Diffusion Tensor Imaging in Complicated versus Uncomplicated Mild Traumatic Brain Injury

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0122746 ◽  
Author(s):  
William J. Panenka ◽  
Rael T. Lange ◽  
Sylvain Bouix ◽  
Jason R. Shewchuk ◽  
Manraj K. S. Heran ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Diffusion Tensor ◽  
Neuropsychological Outcome ◽  
And Diffusion
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