scholarly journals Novel Near‐Infrared Fluorescence‐Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice

2019 ◽  
Vol 37 (5) ◽  
pp. 1192-1201 ◽  
Author(s):  
Tomohiko Sakuda ◽  
Tadahiko Kubo ◽  
Muhammad Phetrus Johan ◽  
Taisuke Furuta ◽  
Takemasa Sakaguchi ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Vesicular Stomatitis Virus ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Complete Surgical Resection ◽  
Vesicular Stomatitis

scholarly journals EpCAM as multi-tumour target for near-infrared fluorescence guided surgery

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
P. B. A. A. van Driel ◽  
M. C. Boonstra ◽  
H. A. J. M. Prevoo ◽  
M. van de Giessen ◽  
T. J. A. Snoeks ◽  
...  
Keyword(s):  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Tumour Target

Real-time near-infrared fluorescence guided surgery in gynecologic oncology: A review of the current state of the art

2014 ◽  
Vol 135 (3) ◽  
pp. 606-613 ◽  
Author(s):  
Henricus J.M. Handgraaf ◽  
Floris P.R. Verbeek ◽  
Quirijn R.J.G. Tummers ◽  
Leonora S.F. Boogerd ◽  
Cornelis J.H. van de Velde ◽  
...  
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
State Of The Art ◽  
Gynecologic Oncology ◽  
Near Infrared Fluorescence ◽  
Guided Surgery ◽  
Current State ◽  
Fluorescence Guided Surgery

scholarly journals (Near-Infrared) Fluorescence-Guided Surgery Under Ambient Light Conditions: A Next Step to Embedment of the Technology in Clinical Routine

2016 ◽  
Vol 23 (8) ◽  
pp. 2586-2595 ◽  
Author(s):  
Nynke S. van den Berg ◽  
Mitsuharu Miwa ◽  
Gijs H. KleinJan ◽  
Takayuki Sato ◽  
Yoshiki Maeda ◽  
...  
Keyword(s):  
Near Infrared ◽  
Ambient Light ◽  
Light Conditions ◽  
Clinical Routine ◽  
Near Infrared Fluorescence ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery

Unexpected Binding of Tozuleristide “Tumor Paint” to Cerebral Vascular Malformations: A Potentially Novel Application of Fluorescence-Guided Surgery

Neurosurgery ◽  
2021 ◽  
Author(s):  
Andrew J Kobets ◽  
David Nauen ◽  
Amy Lee ◽  
Alan R Cohen
Keyword(s):  
Near Infrared ◽  
Vascular Malformations ◽  
Cns Tumors ◽  
Matrix Metalloproteinase 2 ◽  
Cerebrovascular Lesions ◽  
Cavernous Malformations ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Cerebral Vascular Malformations ◽  
Cerebral Vascular

Abstract BACKGROUND Fluorescence-guided surgery (FGS) is under investigation as a means to improve the extent of resection for primary central nervous system (CNS) tumors. Tozuleristide, known also as “Tumor Paint,” is an investigational tumor-targeting agent covalently conjugated to a derivative of the fluorescent dye indocyanine green. OBJECTIVE To report the finding of avid intraoperative fluorescence of tozuleristide on cerebral vascular malformations. METHODS Our institution is participating in a phase 2/3 study of intraoperative near-infrared fluorescence detection of pediatric primary CNS tumors in patients receiving intravenous tozuleristide and imaged with the Canvas system. Our site enrolled 2 patients with intracranial lesions, suspected preoperatively of possibly being gliomas that proved to be cavernous vascular malformations after resection. RESULTS Each lesion had a dark blue mulberry appearance and each fluoresced avidly with tozuleristide. Each was completely resected, and the patients recovered without deficit. Pathological assessment showed cavernous angioma for both cases. Tozuleristide fluorescence is postulated to result from binding to matrix metalloproteinase-2 and annexin A2, and literature review demonstrates expression of both these ligands on multiple cerebrovascular lesions, including cavernous malformations. CONCLUSION This finding deserves further investigation to determine if tozuleristide “Tumor Paint” may have a wider role in the identification of non-neoplastic intracranial pathologies.

scholarly journals SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery

2017 ◽  
Vol 26 (2) ◽  
pp. 153-162 ◽  
Author(s):  
Marian Gutowski ◽  
Bérénice Framery ◽  
Martin C. Boonstra ◽  
Véronique Garambois ◽  
François Quenet ◽  
...  
Keyword(s):  
Near Infrared ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Antibody Conjugate ◽  
Near Infrared Dye
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