scholarly journals Prediction of local fixed charge density loss in cartilage following ACL injury and reconstruction: A computational proof‐of‐concept study with MRI follow‐up

Author(s):  
Gustavo A. Orozco ◽  
Paul Bolcos ◽  
Ali Mohammadi ◽  
Matthew S. Tanaka ◽  
Mingrui Yang ◽  
...  
Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 997
Author(s):  
Alessandro de Sire ◽  
Nicola Marotta ◽  
Andrea Demeco ◽  
Lucrezia Moggio ◽  
Pasquale Paola ◽  
...  

Anterior cruciate ligament (ACL) injury incidence is often underestimated in tennis players, who are considered as subjects conventionally less prone to knee injuries. However, evaluation of the preactivation of knee stabilizer muscles by surface electromyography (sEMG) showed to be a predictive value in the assessment of the risk of ACL injury. Therefore, this proof-of-concept study aimed at evaluating the role of visual input on the thigh muscle preactivation through sEMG to reduce ACL injury risk in tennis players. We recruited male, adult, semiprofessional tennis players from July to August 2020. They were asked to drop with the dominant lower limb from a step, to evaluate—based on dynamic valgus stress—the preactivation time of the rectus femoris (RF), vastus medialis, biceps femoris, and medial hamstrings (MH), through sEMG. To highlight the influence of visual inputs, the athletes performed the test blindfolded and not blindfolded on both clay and grass surfaces. We included 20 semiprofessional male players, with a mean age 20.3 ± 4.8 years; results showed significant early muscle activation when the subject lacked visual input, but also when faced with a less-safe surface such as clay over grass. Considering the posteromedial–anterolateral relationship (MH/RF ratio), tennis players showed a significant higher MH/RF ratio if blindfolded (22.0 vs. 17.0% not blindfolded; p < 0.01) and percentage of falling on clay (17.0% vs. 14.0% in grass; p < 0.01). This proof-of-principle study suggests that in case of absence of visual input or falling on a surface considered unsafe (clay), neuro-activation would tend to protect the anterior stress of the knee. Thus, the sEMG might play a crucial role in planning adequate athletic preparation for semiprofessional male athletes in terms of reduction of ACL injury risk.


2002 ◽  
Vol 47 (2) ◽  
pp. 284-291 ◽  
Author(s):  
Erik M. Shapiro ◽  
Arijitt Borthakur ◽  
Alexander Gougoutas ◽  
Ravinder Reddy

2002 ◽  
pp. 387-395
Author(s):  
Robert J. Wilkins ◽  
Bethan Hopewell ◽  
Jill P. G. Urban

1988 ◽  
Vol 254 (3) ◽  
pp. F364-F373 ◽  
Author(s):  
M. Wolgast ◽  
G. Ojteg

In the classical Starling model the hydrostatic pressure in the pores is generally lower than that in capillary plasma, a phenomenon that necessitates the assumption of a rigid porous membrane. In flexible gel membranes, the capillary pressure is suggested to be balanced by a gel swelling pressure generated by negative fixed charges. Regarding the fluid transfer, the transmembranous electrical potential gradient will generate a net driving electroosmotic force. This force will be numerically similar to the net driving Starling force in small pores, but distinctly different in large pores. From previous data on the hydrostatic and colloid osmotic forces, the fixed charge density at the two interfaces of 1) the glomerular and 2) the peritubular capillary membrane were calculated and used to predict the flux of a series of charged protein probes. The close fit to the experimental data in both the capillary beds is in line with the gel concept presented. The gel concept (but hardly a rigid membrane) explains the ability of capillary membranes to alter their permeability in response to external forces. Gel membranes can furthermore be predicted to have a self-rinsing ability, as entrapped proteins will increase the local fixed charge density, leading to fluid entry into the region between the particle and the pore rim, which by consequent widening of the channel will facilitate extrusion of trapped proteins.


1983 ◽  
Vol &NA; (177) ◽  
pp. 283???288 ◽  
Author(s):  
ISAO HASEGAWA ◽  
SHINYA KURIKI ◽  
SHIGEO MATSUNO ◽  
GORO MATSUMOTO

Spine ◽  
1989 ◽  
Vol 14 (11) ◽  
pp. 1226-1233 ◽  
Author(s):  
SATORU KITANO ◽  
HARUO TSUJI ◽  
NORIKAZU HIRANO ◽  
AKIMI SANO ◽  
NOBUO TERAHATA

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