Phthalocyanine photophysics and photosensitizer efficiency on human embryonic lung fibroblasts

2001 ◽  
Vol 05 (05) ◽  
pp. 460-464 ◽  
Author(s):  
JOHN W. OWENS ◽  
MARSHA ROBINS
Keyword(s):  
Quantum Yield ◽  
Photophysical Properties ◽  
Fluorescence Emission ◽  
Zinc Phthalocyanine ◽  
Lung Fibroblasts ◽  
Quantum Yields ◽  
Cancer Drug ◽  
Embryonic Lung ◽  
Human Embryonic Lung ◽  
Triplet Formation

This study correlates the photophysical properties of aluminum phthalocyanine tetrasulfonate (AlPcTs), zinc phthalocyanine tetrasulfonate (ZnPcTs), and phthalocyanine tetrasulfonate (PcTs) with their ability to kill human embryonic lung (HEL) cells. Photofrin, a proven anti-cancer drug, was used for comparison. The photophysical properties include fluorescence emission spectra, fluorescence quantum yields, singlet state and radiative lifetimes, quantum yield for triplet formation, and fluorescence rate constants. Results indicate that photodynamic efficacy correlates inversely with fluorescence quantum yield and fluorescence lifetime and directly with quantum yield for triplet formation.

Synthesis, photophysicochemical studies of adjacently tetrasubstituted binaphthalo-phthalocyanines

2005 ◽  
Vol 09 (05) ◽  
pp. 316-325 ◽  
Author(s):  
Itumeleng Seotsanyana-Mokhosi ◽  
Ji-Yao Chen ◽  
Tebello Nyokong
Keyword(s):  
Excited State ◽  
Quantum Yield ◽  
Triplet State ◽  
Singlet Oxygen ◽  
Photophysical Properties ◽  
Zinc Phthalocyanine ◽  
Quantum Yields ◽  
Triplet Excited State ◽  
General Increase ◽  
Photochemical Behavior

Adjacent binaphthalo-phthalocyanines tetra-substituted with phenoxy (4a), 4-carboxyphenoxy (4b) and 4-t-butylphenoxy (4c) groups, as well as the di-substituted 4-carboxyphenoxy (5b) have been synthesized and characterized. The photophysical and photochemical behavior of 4a-c, were compared with those of the corresponding di-substituted derivatives, (5a-c). The secondary substituents on the phenoxy ring have an influence on the aggregation of the molecules and hence on their photophysical properties. All of the complexes exhibit a relatively good conversion of energy from the triplet-excited state to the singlet oxygen. The less aggregated molecule (4c), has the highest singlet oxygen quantum yield. For all the molecules, fluorescence yields are low and they all have relatively shorter triplet lifetimes compared with the unsubstituted zinc phthalocyanine. Increasing the number of ring substituents on these rigid MPc complexes (from complexes 5 to 4) showed a general increase in the triplet state lifetimes and singlet oxygen quantum yields, and a decrease in stability.

Influence of cyclodextrins on the fluorescence, photostability and singlet oxygen quantum yields of zinc phthalocyanine and naphthalocyanine complexes

2003 ◽  
Vol 07 (06) ◽  
pp. 439-446 ◽  
Author(s):  
Prudence Tau ◽  
Abimbola O. Ogunsipe ◽  
Suzanne Maree ◽  
M. David Maree ◽  
Tebello Nyokong
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Inclusion Complexes ◽  
Photophysical Properties ◽  
Zinc Phthalocyanine ◽  
Quantum Yields ◽  
Fluorescence Quantum Yields ◽  
Cyclodextrin Inclusion Complexes ◽  
Cyclodextrin Inclusion ◽  
Zinc Phthalocyanines

The effects of formation of cyclodextrin inclusion complexes on the photochemical and photophysical properties of zinc phthalocyanine ( ZnPc ) and various peripherally substituted zinc phthalocyanines as well as zinc naphthalocyanine ( ZnNPc ) are investigated. The cyclodextrins employed were the hydroxypropyl-γ-cyclodextrin and unsubstituted β-cyclodextrin. Job's plots were employed to confirm the stoichiometry of the inclusion complexes and showed 2:1 and 4:1 (cyclodextrin:phthalocyanine) inclusion behavior. The phthalocyanine inclusion complexes showed larger singlet oxygen quantum yield (ϕΔ) values when compared to the free phthalocyanines before inclusion, for complexes 1 (zinc naphthalocyanine), 2 (zinc tetranitrophthalocyanine) and 4 (zinc tetra-tert-butylphenoxyphthalocyanine). The fluorescence quantum yields generally remained unchanged following inclusion.

Genotoxic Effect of a New Water-Soluble Fullerene Derivative C70 and its Effect on the Transcriptional Activity of Genes that Regulate the Cell Cycle, DNA Repair and Apoptosis

2021 ◽  
Vol 1031 ◽  
pp. 222-227
Author(s):  
Ekaterina A. Savinova ◽  
Elizaveta S. Ershova ◽  
Olga A. Kraevaya ◽  
Pavel A. Troshin ◽  
S.V. Kostyuk
Keyword(s):  
Cell Cycle ◽  
Transcriptional Activity ◽  
Water Soluble ◽  
Lung Fibroblasts ◽  
Fullerene Derivative ◽  
Embryonic Lung ◽  
Dna Breaks ◽  
Human Embryonic Lung ◽  
Fullerene Derivatives ◽  
Cellular Dna

It is important to take into consideration the new fullerene derivatives genotoxicity. In the present is study, we analyzed the new water-soluble fullerene C70 (F350) effects on the human embryonic lung fibroblasts (HELF) oxidative damage and DNA breaks. We found that the studied compound causes cellular DNA damage and affects the transcriptional activity of cell cycle and cell apoptosis regulating genes.

Effects of MRI Contrast Agents on Human Embryonic Lung Fibroblasts

2010 ◽  
Vol 45 (9) ◽  
pp. 513-519 ◽  
Author(s):  
Benjamin Wiesinger ◽  
Rainer Kehlbach ◽  
Julie Bebin ◽  
Jennifer Hemsen ◽  
Rüdiger Bantleon ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Lung Fibroblasts ◽  
Embryonic Lung ◽  
Human Embryonic Lung ◽  
Mri Contrast

scholarly journals Thalidomide inhibits the gene promoter of connective tissue growth factor in human embryonic lung fibroblasts

2020 ◽  
Vol 9 (5) ◽  
pp. 2516-2523
Author(s):  
Yonghui Wu ◽  
Libao Liu ◽  
Jian Zhang ◽  
Lei Huang ◽  
Shaohong Huang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Gene Promoter ◽  
Tissue Growth ◽  
Lung Fibroblasts ◽  
Embryonic Lung ◽  
Human Embryonic Lung

Induction of Fc (IgG) Receptor(s) by Simian Cytomegaloviruses in Human Embryonic Lung Fibroblasts

Intervirology ◽  
1988 ◽  
Vol 29 (6) ◽  
pp. 339-345 ◽  
Author(s):  
Yoshito Eizuru ◽  
Yoichi Minamishima
Keyword(s):  
Lung Fibroblasts ◽  
Embryonic Lung ◽  
Human Embryonic Lung

Toxic and DNA damaging effects of a functionalized fullerene in human embryonic lung fibroblasts

2016 ◽  
Vol 805 ◽  
pp. 46-57 ◽  
Author(s):  
E.S. Ershova ◽  
V.A. Sergeeva ◽  
A.I. Chausheva ◽  
D.G. Zheglo ◽  
V.A. Nikitina ◽  
...  
Keyword(s):  
Lung Fibroblasts ◽  
Embryonic Lung ◽  
Human Embryonic Lung ◽  
Damaging Effects

Scatter factor from human embryonic lung fibroblasts is probably identical to hepatocyte growth factor

1991 ◽  
Vol 180 (2) ◽  
pp. 765-773 ◽  
Author(s):  
Tetsumi Konishi ◽  
Toyohiro Takehara ◽  
Takashi Tsuji ◽  
Keiichi Ohsato ◽  
Kunio Matsumoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Lung Fibroblasts ◽  
Embryonic Lung ◽  
Human Embryonic Lung ◽  
Scatter Factor ◽  
Hepatocyte Growth
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