Ipsilateral breast tumor reappearance in patients treated with conservative surgery after primary chemotherapy. The role of surgical margins on outcome

2006 ◽  
Vol 94 (5) ◽  
pp. 375-379 ◽  
Author(s):  
Oreste Gentilini ◽  
Mattia Intra ◽  
Sara Gandini ◽  
Giulia Peruzzotti ◽  
Erik Winnikow ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Conservative Surgery ◽  
Surgical Margins ◽  
Primary Chemotherapy ◽  
Ipsilateral Breast

Conservative surgery for ipsilateral breast tumor recurrence

2014 ◽  
Vol 110 (1) ◽  
pp. 62-67 ◽  
Author(s):  
Jose Vila ◽  
Carlos A. Garcia-Etienne ◽  
Andrea Vavassori ◽  
Oreste Gentilini
Keyword(s):  
Breast Tumor ◽  
Tumor Recurrence ◽  
Ipsilateral Breast Tumor Recurrence ◽  
Conservative Surgery ◽  
Ipsilateral Breast

scholarly journals Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy

Cancer ◽  
2003 ◽  
Vol 97 (4) ◽  
pp. 926-933 ◽  
Author(s):  
Funda Meric ◽  
Nadeem Q. Mirza ◽  
Georges Vlastos ◽  
Thomas A. Buchholz ◽  
Henry M. Kuerer ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Tumor Recurrence ◽  
Ipsilateral Breast Tumor Recurrence ◽  
Breast Conserving Therapy ◽  
Surgical Margins ◽  
Disease Specific Survival ◽  
Ipsilateral Breast ◽  
Positive Surgical Margins ◽  
Disease Specific

Repeating Conservative Surgery after Ipsilateral Breast Tumor Reappearance: Criteria for Selecting the Best Candidates

2012 ◽  
Vol 19 (12) ◽  
pp. 3771-3776 ◽  
Author(s):  
Oreste Gentilini ◽  
Edoardo Botteri ◽  
Paolo Veronesi ◽  
Claudia Sangalli ◽  
Andres Del Castillo ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Conservative Surgery ◽  
Ipsilateral Breast

Primary Chemotherapy for Operable Breast Cancer: Incidence and Prognostic Significance of Ipsilateral Breast Tumor Recurrence After Breast-Conserving Surgery

2001 ◽  
Vol 19 (18) ◽  
pp. 3828-3835 ◽  
Author(s):  
Roman Rouzier ◽  
Jean-Marc Extra ◽  
Mathieu Carton ◽  
Marie-Christine Falcou ◽  
Anne Vincent-Salomon ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Multivariate Analysis ◽  
Breast Tumor ◽  
Tumor Recurrence ◽  
Estrogen Receptor Status ◽  
Ipsilateral Breast Tumor Recurrence ◽  
Breast Conserving Surgery ◽  
Primary Chemotherapy ◽  
Ipsilateral Breast ◽  
Receptor Status

PURPOSE: To determine the incidence and the prognostic value of ipsilateral breast tumor recurrence (IBTR) in patients treated with primary chemotherapy and breast-conserving surgery. PATIENTS AND METHODS: Between January 1985 and December 1994, 257 patients with invasive T1 to T3 breast carcinoma were treated with primary chemotherapy, lumpectomy, and radiation therapy. The median follow-up time was 93 months. To evaluate the role of IBTR in metastase-free survival, a Cox regression multivariate analysis was performed using IBTR as a time-dependent covariate. RESULTS: The IBTR rates were 16% (± 2.4%) at 5 years and 21.5% (± 3.2%) at 10 years. Multivariate analysis showed that the probability of local control was decreased by the following independent factors: age ≤ 40 years, excision margin ≤ 2 mm, S-phase fraction more than 4%, and clinical tumor size more than 2 cm at the time of surgery. In patients with excision margins of more than 2 mm, the IBTR rates were 12.7% at 5 years and 17% at 10 years. Nodal status, age ≤ 40 years, and negative estrogen receptor status were predictors of distant disease in the Cox multivariate model with fixed covariates. The contribution of IBTR was highly significant (relative risk = 5.34) when added to the model, whereas age ≤ 40 years was no longer significant. After IBTR, 31.4% (± 7.0%) of patients developed metastases at 2 years and 59.7% (± 8.1%) at 5 years. Skin involvement, size at initial surgery, and estrogen receptor status were predictors of metastases after IBTR. CONCLUSION: IBTR is a strong predictor for distant metastases. There are implications for conservative surgery after downstaging of the tumor and therapy at the time of IBTR.

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