Chiral separation of some non-steroidal anti-inflammatory drugs on tartardiamide DMB chiral stationary phase by HPLC

2003 ◽  
Vol 26 (6-7) ◽  
pp. 521-524 ◽  
Author(s):  
Hassan Y. Aboul-Enein
Keyword(s):  
Stationary Phase ◽  
Chiral Separation ◽  
Chiral Stationary Phase ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Preparation of a Novel Chiral Stationary Phase Containing Rhizobial Cyclic β-(1 → 2) Glucans for the Chiral Separation of Some Flavonoids

2015 ◽  
Vol 36 (9) ◽  
pp. 2379-2382 ◽  
Author(s):  
Daham Jeong ◽  
Hwanhee Kim ◽  
Someshwar D Dindulkar ◽  
Jae Yung Lee ◽  
Seunho Jung
Keyword(s):  
Stationary Phase ◽  
Chiral Separation ◽  
Chiral Stationary Phase

scholarly journals Chromatographic and spectroscopic studies on β-cyclodextrin functionalized ionic liquid as chiral stationary phase: Enantioseparation of NSAIDs

2017 ◽  
Vol 36 (1-2) ◽  
pp. 130-148 ◽  
Author(s):  
Nurul Yani Rahim ◽  
Kheng Soo Tay ◽  
Sharifah Mohamad
Keyword(s):  
Ionic Liquid ◽  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Stationary Phases ◽  
Spectroscopic Studies ◽  
Inclusion Complex Formation ◽  
H Nmr ◽  
Inflammatory Drugs ◽  
And Performance ◽  
Multiple Interactions

Recently, we reported a new chiral stationary phase prepared using β-cyclodextrin functionalized with aromatic ionic liquid which is aimed to enhance the performance of enantioseparation of flavonoids and β-blockers. In this paper, the characteristics and performance of previously prepared chiral stationary phase denoted as β-CD-BIMOTs were compared with the newly synthesized chiral stationary phase denoted as β-CD-DIMOTs. β-CD-DIMOTs were prepared by functionalization of β-cyclodextrin with aliphatic ionic liquid. The obtained β-CD-BIMOTs and β-CD-DIMOTs stationary phases were compared with native β-CD stationary phase for the enantioseparation of non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, indoprofen, ketoprofen and fenoprofen). The β-CD-BIMOTs stationary phase showed greater chiral resolution capabilities rather than β-CD-DIMOTs and native β-CD stationary phases. Further, in order to understand the interaction of enantioseparation, the inclusion complex formation between NSAIDs and β-CD-BIMOTs was studied using 1H NMR, NOESY and UV/Vis. The enantioseparated NSAIDs were found to form multiple interactions with β-CD-BIMOTs-CSP.

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