Recurrence of sinonasal inverted papilloma following surgical approach: A meta-analysis

Background: Although the role of human papillomavirus (HPV) in sinonasal inverted papilloma (SNIP) has been investigated, the link between HPV infection and SNIP recurrence remains controversial. This meta-analysis aimed to investigate the association between HPV infection and recurrence of SNIP. Methods: The PubMed, Web of Science, Google Scholar, and Cochrane Library databases were searched (until 16 June 2021) to collect all relevant articles. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using the fixed effects model. In addition, subgroup analysis, assessment of publication bias, and sensitivity analyses were performed. Results: Fourteen eligible articles, including 592 patients with SNIP, were included in this study. Pooled analysis revealed that HPV-positive cases exhibited a significantly higher OR of tumour recurrence than HPV-negative counterparts). A significant association between HPV infection and tumour recurrence remained stable in subgroup analyses according to the publication year of the studies. Conclusions: Our meta-analysis demonstrates that HPV infection is significantly associated with the recurrence of SNIP, suggesting the pathological role of HPV in SNIP. These results suggest that HPV infection should be considered in the management of SNIP.

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Clinical Analysis of 382 Sinonasal Inverted Papilloma Cases Treated at A Single Tertiary Medical Center

Journal of Rhinology ◽

10.18787/jr.2020.00309 ◽

2020 ◽

Vol 27 (2) ◽

pp. 102-107

Author(s):

Soo Kyoung Park ◽

Geonho Lee ◽

Min Su Kim ◽

Yong Min Kim ◽

Ki-Sang Rha

Keyword(s):

Risk Factors ◽

Recurrence Rate ◽

Surgical Approach ◽

Medical Center ◽

Demographic Data ◽

Inverted Papilloma ◽

Sinonasal Inverted Papilloma ◽

Associated Malignancy ◽

Risk Factors For Recurrence

Background and Objectives: Sinonasal inverted papilloma (IP) is a benign tumor with a locally aggressive nature and a propensity to recur. Many risk factors for recurrence have been reported, but they are still controversial. The aim of this study was to comprehensively assess the demographic data, clinical features, and potential risk factors for recurrence of IP.Subjects and Method: This work is a retrospective review of 382 patients diagnosed with and treated for sinonasal inverted papilloma between 1986 and 2017 at a single tertiary medical center. Demographic data, presence of associated malignancy, information about previous surgeries, tumor location, Krouse stage, surgical approach, follow-up duration, and data on recurrence were obtained.Results: In our study, 31 of 382 cases (8.1%) were associated with malignancy. Mean age was significantly higher in patients with associated malignancy compared to the benign IP group. Of the 351 benign cases, 263 (74.9%) were primary, and 88 (25.1%) were revision cases (residual or recurrent disease). Although the proportion of patients with high Krouse stage or multifocal involvement was high in the revision cases, there was no significant difference in recurrence rate. The 226 patients with a minimum follow-up of 1 year were included for recurrence analysis. Recurrence rate was significantly higher in the conventional surgery group (17.4%) compared to that of the endoscopic and combined surgery groups (8.1% and 3.6%, respectively). Also, the recurrence group showed significantly larger proportion of patients with high Krouse stage and multifocal involvement.Conclusion: Risk factors for recurrence of IP found in this study are comparable to those previously published. Generally, the factors associated with recurrence of IP were prior surgery, clinical stage, involved site, and surgical approach. Therefore, surgeons should always consider these risk factors to reduce the chance of recurrence.

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Attachment-oriented endoscopic surgical approach for sinonasal inverted papilloma

Operative Techniques in Otolaryngology-Head and Neck Surgery ◽

10.1016/j.otot.2006.03.003 ◽

2006 ◽

Vol 17 (2) ◽

pp. 87-96 ◽

Cited By ~ 4

Author(s):

Roee Landsberg

Keyword(s):

Surgical Approach ◽

Inverted Papilloma ◽

Sinonasal Inverted Papilloma

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Role of High‐Risk HPV Detected by PCR in Malignant Sinonasal Inverted Papilloma: A Meta‐Analysis

The Laryngoscope ◽

10.1002/lary.29735 ◽

2021 ◽

Author(s):

Justin P. McCormick ◽

Jeffrey D. Suh ◽

Jivianne T. Lee ◽

Christine Wells ◽

Marilene B. Wang

Keyword(s):

High Risk ◽

Meta Analysis ◽

Inverted Papilloma ◽

Sinonasal Inverted Papilloma ◽

High Risk Hpv

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Staging of surgical approach of sinonasal inverted papilloma

Auris Nasus Larynx ◽

10.1016/j.anl.2005.03.015 ◽

2005 ◽

Vol 32 (3) ◽

pp. 257-263 ◽

Cited By ~ 16

Author(s):

Hideaki Katori ◽

Mamoru Tsukuda

Keyword(s):

Surgical Approach ◽

Inverted Papilloma ◽

Sinonasal Inverted Papilloma

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Endoscopic Modified Medial Maxillectomy for Resection of an Inverted Papilloma Originating from the Entire Circumference of the Maxillary Sinus

Case Reports in Otolaryngology ◽

10.1155/2015/952923 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6

Author(s):

Kota Wada ◽

Takashi Ishigaki ◽

Yutaro Ida ◽

Yuki Yamada ◽

Sachiko Hosono ◽

...

Keyword(s):

Maxillary Sinus ◽

Surgical Approach ◽

Staging System ◽

Inferior Turbinate ◽

Nasolacrimal Duct ◽

Inverted Papilloma ◽

Sinonasal Inverted Papilloma ◽

Medial Maxillectomy ◽

Magnetic Resonance Imaging Mri ◽

Modified Medial Maxillectomy

For treatment of a sinonasal inverted papilloma (IP), it is essential to have a definite diagnosis, to identify its origin by computed tomography (CT) and magnetic resonance imaging (MRI), and to select the appropriate surgical approach based on the staging system proposed by Krouse. Recently, a new surgical approach named endoscopic modified medial maxillectomy (EMMM) was proposed. This approach can preserve the inferior turbinate and nasolacrimal duct. We successfully treated sinonasal IP with EMMM in a 71-year-old female patient. In this patient, the sinonasal IP originated from the entire circumference of the maxillary sinus. EMMM is not a difficult procedure and provides good visibility of the operative field. Lacrimation and empty nose syndrome do not occur postoperatively as the nasolacrimal duct and inferior turbinate are preserved. EMMM is considered to be a very favorable approach for treatment of sinonasal IP.

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