Near‐infrared stimulation of the auditory nerve: A decade of progress toward an optical cochlear implant

Electrical stimulation of the auditory nerve in the profoundly deaf population through implanted cochlear prostheses has increased the need for reliable electrophysiologic assessment tools. We have recorded electrically evoked brainstem responses (EABRs) in 21 subjects who have received a 3M/House cochlear implant. Recordings have been made, both intraoperatively and postoperatively, in the laboratory setting. The recording technique, methods of stimulus artifact suppression, and results of our measurements are described. Clinical applications of this technology are suggested.

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Near-Infrared Laser Stimulation of the Auditory Nerve in Guinea Pigs

Journal of the Optical Society of Korea ◽

10.3807/josk.2016.20.2.269 ◽

2016 ◽

Vol 20 (2) ◽

pp. 269-275 ◽

Cited By ~ 2

Author(s):

Tian Guan ◽

Jian Wang ◽

Muqun Yang ◽

Kai Zhu ◽

Yong Wang ◽

...

Keyword(s):

Auditory Nerve ◽

Guinea Pigs ◽

Near Infrared ◽

Infrared Laser ◽

Laser Stimulation ◽

Stimulation Of

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Responses of dorsal cochlear nucleus single units to electrical pulse train stimulation of the auditory nerve with a cochlear implant electrode

The Journal of the Acoustical Society of America ◽

10.1121/1.412977 ◽

1995 ◽

Vol 97 (4) ◽

pp. 2378-2393 ◽

Cited By ~ 2

Author(s):

Stephen J. O’Leary ◽

Yit C. Tong ◽

Graeme M. Clark

Keyword(s):

Cochlear Implant ◽

Cochlear Nucleus ◽

Auditory Nerve ◽

Pulse Train ◽

Dorsal Cochlear Nucleus ◽

Electrical Pulse ◽

Single Units ◽

Train Stimulation ◽

Stimulation Of

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Evoked Potentials from the Auditory Nerve Following Sinusoidal Electrical Stimulation of the Cochlea: New Possibilities for Preoperative Testing in Cochlear-Implant Candidates?

Acta Oto-Laryngologica ◽

10.3109/00016489409126093 ◽

1994 ◽

Vol 114 (5) ◽

pp. 495-500 ◽

Cited By ~ 7

Author(s):

R. Hartmann ◽

T. Pfennigdorff ◽

R. Klinke

Keyword(s):

Electrical Stimulation ◽

Cochlear Implant ◽

Evoked Potentials ◽

Auditory Nerve ◽

Preoperative Testing ◽

Stimulation Of

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ELECTRICAL STIMULATION OF THE AUDITORY NERVE: THE CODING OF FREQUENCY, THE PERCEPTION OF PITCH AND THE DEVELOPMENT OF COCHLEAR IMPLANT SPEECH PROCESSING STRATEGIES FOR PROFOUNDLY DEAF PEOPLE

Clinical and Experimental Pharmacology and Physiology ◽

10.1111/j.1440-1681.1996.tb01178.x ◽

1996 ◽

Vol 23 (9) ◽

pp. 766-776 ◽

Cited By ~ 33

Author(s):

Graeme M. Clark

Keyword(s):

Electrical Stimulation ◽

Cochlear Implant ◽

Speech Processing ◽

Auditory Nerve ◽

Deaf People ◽

Processing Strategies ◽

Stimulation Of

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Simulating the dual-peak excitation pattern produced by bipolar stimulation of a cochlear implant: Effects on speech intelligibility

Hearing Research ◽

10.1016/j.heares.2014.11.001 ◽

2015 ◽

Vol 319 ◽

pp. 32-47 ◽

Cited By ~ 9

Author(s):

Quentin Mesnildrey ◽

Olivier Macherey

Keyword(s):

Cochlear Implant ◽

Speech Intelligibility ◽

Bipolar Stimulation ◽

Excitation Pattern ◽

Stimulation Of

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53: Direct Stimulation of the Auditory Nerve: Feasibility of a Thin-Film Microelectrode Array

Otolaryngology ◽

10.1016/s0194-5998(96)80677-2 ◽

1996 ◽

Vol 115 (2) ◽

pp. P94-P95

Author(s):

Derek A. Jones ◽

H. Alexander Arts ◽

Steven M. Bierer ◽

David J Anderson

Keyword(s):

Thin Film ◽

Auditory Nerve ◽

Microelectrode Array ◽

Direct Stimulation ◽

Stimulation Of

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Electrical stimulation of the auditory nerve: direct current measurement in vivo

IEEE Transactions on Biomedical Engineering ◽

10.1109/10.752943 ◽

1999 ◽

Vol 46 (4) ◽

pp. 461-469 ◽

Cited By ~ 89

Author(s):

C.Q. Huang ◽

R.K. Shepherd ◽

P.M. Center ◽

P.M. Seligman ◽

B. Tabor

Keyword(s):

Electrical Stimulation ◽

Direct Current ◽

Auditory Nerve ◽

Current Measurement ◽

Direct Current Measurement ◽

Stimulation Of

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Photothermal modulation of human stem cells using light-responsive 2D nanomaterials

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1914345117 ◽

2020 ◽

Vol 117 (24) ◽

pp. 13329-13338

Author(s):

James K. Carrow ◽

Kanwar Abhay Singh ◽

Manish K. Jaiswal ◽

Adelina Ramirez ◽

Giriraj Lokhande ◽

...

Keyword(s):

Stem Cells ◽

Near Infrared ◽

Global Gene Expression ◽

Cellular Migration ◽

Human Stem Cells ◽

Cellular Functions ◽

Nir Light ◽

Whole Transcriptome Sequencing ◽

Whole Transcriptome ◽

Stimulation Of

Two-dimensional (2D) molybdenum disulfide (MoS2) nanomaterials are an emerging class of biomaterials that are photoresponsive at near-infrared wavelengths (NIR). Here, we demonstrate the ability of 2D MoS2to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS2and NIR stimulation of MoS2with human stem cells is investigated using whole-transcriptome sequencing (RNA-seq). Global gene expression profile of stem cells reveals significant influence of MoS2and NIR stimulation of MoS2on integrins, cellular migration, and wound healing. The combination of MoS2and NIR light may provide new approaches to regulate and direct these cellular functions for the purposes of regenerative medicine as well as cancer therapy.

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