scholarly journals Acute graft-versus-host disease after liver transplantation: Role of withdrawal of immunosuppression in therapeutic management

2006 ◽  
Vol 13 (1) ◽  
pp. 157-161 ◽  
Author(s):  
Srinath Chinnakotla ◽  
Douglas M. Smith ◽  
Rana Domiati-Saad ◽  
Edward D. Agura ◽  
David L. Watkins ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Versus Host Disease ◽  
Therapeutic Management ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

scholarly journals The Role of Intestinal Microbiota in Acute Graft-versus-Host Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Yuanyuan Chen ◽  
Ye Zhao ◽  
Qiao Cheng ◽  
Depei Wu ◽  
Haiyan Liu
Keyword(s):  
Immune Responses ◽  
Intestinal Microbiota ◽  
Graft Versus Host Disease ◽  
Inflammatory Diseases ◽  
Hematopoietic Stem ◽  
Host Disease ◽  
Graft Versus Host ◽  
Host Immune Responses ◽  
Acute Graft

The mammalian intestinal microbiota is a complex ecosystem that plays an important role in host immune responses. Recent studies have demonstrated that alterations in intestinal microbiota composition are linked to multiple inflammatory diseases in humans, including acute graft-versus-host disease (aGVHD). aGVHD is one of the major obstacles in allogeneic hematopoietic stem cell transplantation (allo-HSCT), characterized by tissue damage in the gastrointestinal (GI) tract, liver, lung, and skin. Here, we review the current understanding of the role of intestinal microbiota in the control of immune responses during aGVHD. Additionally, the possibility of using probiotic strains for potential treatment or prevention of aGVHD will be discussed.

Two Cases and a Review of Graft-Versus-Host Disease and the Role of Hepatitis C Treatment in Liver Transplant Patients

2018 ◽  
Vol 28 (3) ◽  
pp. 267-270 ◽  
Author(s):  
Sonali D. Advani ◽  
Anoma Nellore ◽  
Giorgos Hadjivassiliou ◽  
Devin E. Eckhoff ◽  
Donna Salzman ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis C ◽  
Graft Versus Host Disease ◽  
High Dose ◽  
Solid Organ ◽  
Hcv Treatment ◽  
Host Disease ◽  
Graft Versus Host ◽  
Transplant Patients

Graft-versus-host disease (GvHD) is a rare but fatal complication after solid organ transplantation arising in 1% to 2% of cases. We report 2 cases of GvHD after orthotopic liver transplantation. Both patients had a history of hepatitis C virus (HCV) infection prior to transplantation. Both cases presented between 1 and 4 months after transplantation with rash, pancytopenia, and/or diarrhea. Our second case also developed oral and ocular manifestations after liver transplantation, which are more commonly described after stem cell transplantation. Diagnosis in both cases was made by clinical presentation in conjunction with histopathology and flow cytometry. Both patients were treated by increasing immunosuppression with tacrolimus and high-dose steroids. Response to treatment differed based on the degree of pancytopenia. Our case report is distinguished by several factors such as the context of GvHD presentation and the role of HCV treatment. Diagnosis of GvHD is difficult and often delayed due to nonspecific presentation that overlaps with other conditions. Furthermore, the relation between HCV treatment and potential initiation of GvHD in solid organ transplant patients is unclear.

Acute Graft-Versus-Host Disease After Liver Transplantation

2007 ◽  
Vol 83 (3) ◽  
pp. 365-366 ◽  
Author(s):  
M Peter Ghali ◽  
Jayant A. Talwalkar ◽  
S Breanndan Moore ◽  
William J. Hogan ◽  
K V. Narayanan Menon ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

Role of Toll-like receptor 9 (TLR-9) in acute graft-versus-host disease

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 7037-7037
Author(s):  
A. Balsari ◽  
C. Calcaterra ◽  
L. Sfondrini ◽  
A. Rossini ◽  
S. Ménard
Keyword(s):  
Graft Versus Host Disease ◽  
Toll Like Receptor ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft
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