scholarly journals Straightforward Determination of the Degree of N -Acetylation of Chitosan by Means of First-Derivative UV Spectrophotometry

2008 ◽  
Vol 209 (14) ◽  
pp. 1463-1472 ◽  
Author(s):  
Ricardo M. P. da Silva ◽  
João F. Mano ◽  
Rui L. Reis
Keyword(s):  
Uv Spectrophotometry ◽  
First Derivative ◽  
Derivative Uv Spectrophotometry

scholarly journals Spectrophotometric determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in dosage forms

2013 ◽  
Vol 2 (5) ◽  
pp. 97-100 ◽  
Author(s):  
Arun Kaura ◽  
Vikas Gupta ◽  
G S Roy ◽  
Monika Kaura
Keyword(s):  
Pharmaceutical Journal ◽  
Dosage Forms ◽  
Uv Spectrophotometry ◽  
Chlorpheniramine Maleate ◽  
Simple Method ◽  
Pharmaceutical Dosage Forms ◽  
First Derivative ◽  
Phenylpropanolamine Hydrochloride ◽  
Derivative Uv Spectrophotometry

A rapid and simple method for simultaneous determination of Chlorpheniramine Maleate (CPM) and Phenylpropanolamine Hydrochloride (PPM) by first derivative UV spectrophotometry has been developed in combined pharmaceutical dosage forms. The proposed method was successfully applied for the determination of drugs in physical mixture and commercial formulations and results showed good linearity, precision and reproducibility. DOI: http://dx.doi.org/10.3329/icpj.v2i5.14436 International Current Pharmaceutical Journal, April 2013, 2(5): 97-100 

scholarly journals Simultaneous Determination of Amlodipine and Valsartan

2011 ◽  
Vol 6 ◽  
pp. ACI.S7282 ◽  
Author(s):  
Nashwah Gadallah Mohamed
Keyword(s):  
Absorption Spectrum ◽  
Simultaneous Determination ◽  
Zero Order ◽  
Uv Spectrophotometry ◽  
Ratio Spectrum ◽  
First Derivative ◽  
Bulk Powder ◽  
Overlapped Peaks ◽  
Third Derivative

A spectrophotometric method was developed for simultaneous determination of amlodipine (Aml) and valsartan (Val) without previous separation. In this method amlodipine in methanolic solution was determined using zero order UV spectrophotometry by measuring its absorbency at 360.5 nm without any interference from valsartan. Valsartan spectrum in zero order is totally overlapped with that of amlodipine. First, second and third derivative could not resolve the overlapped peaks. The first derivative of the ratio spectra technique was applied for the measurement of valsartan. The ratio spectrum was obtained by dividing the absorption spectrum of the mixture by that of amlodipine, so that the concentration of valsartan could be determined from the first derivative of the ratio spectrum at 290 nm. Quantification limits of amlodipine and valsartan were 10-80 μg/ml and 20-180 μg/ml respectively. The method was successfully applied for the quantitative determination of both drugs in bulk powder and pharmaceutical formulation.

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