Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor α

2005 ◽  
Vol 44 (4) ◽  
pp. 252-261 ◽  
Author(s):  
Y. Alan Wang ◽  
Kate Shen ◽  
Yasumasa Ishida ◽  
Yaolin Wang ◽  
Akira Kakizuka ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Dominant Negative ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Α ◽  
Murine Leukemia

scholarly journals Akt phosphorylates and suppresses the transactivation of retinoic acid receptor α

2006 ◽  
Vol 395 (3) ◽  
pp. 653-662 ◽  
Author(s):  
Harish Srinivas ◽  
Dianren Xia ◽  
Nicole L. Moore ◽  
Ivan P. Uray ◽  
Heetae Kim ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Suppressive Effect ◽  
Dominant Negative ◽  
Nsclc Cell Line ◽  
Acid Receptor ◽  
Growth Inhibitory ◽  
Dominant Negative Form ◽  
Retinoic Acid Receptor Α ◽  
Functional Analyses

The transactivation of nuclear receptors is regulated by both ligand binding and phosphorylation. We previously showed that RARα (retinoic acid receptor α) phosphorylation by c-Jun N-terminal kinase contributes to retinoid resistance in a subset of NSCLC cells (non-small cell lung cancer cells), but the aetiology of this resistance in the remainder has not been fully elucidated [Srinivas, Juroske, Kalyankrishna, Cody, Price, Xu, Narayanan, Weigel and Kurie (2005) Mol. Cell. Biol. 25, 1054–1069]. In the present study, we report that Akt, which is constitutively activated in NSCLC cells, phosphorylates RARα and inhibits its transactivation. Biochemical and functional analyses showed that Akt interacts with RARα and phosphorylates the Ser96 residue of its DNA-binding domain. Mutation of Ser96 to alanine abrogated the suppressive effect of Akt. Overexpression of a dominant-negative form of Akt in an NSCLC cell line decreased RAR phosphorylation, increased RAR transactivation and enhanced the growth-inhibitory effects of an RAR ligand. The findings presented here show that Akt inhibits RAR transactivation and contributes to retinoid resistance in a subset of NSCLC cells.

Retinoic Acid Inhibits Nitric Oxide Synthase-2 Expression through the Retinoic Acid Receptor-α

2000 ◽  
Vol 270 (3) ◽  
pp. 846-851 ◽  
Author(s):  
Allan Sirsjö ◽  
Andreas C Gidlöf ◽  
Anneli Olsson ◽  
Hans Törmä ◽  
Mikko Ares ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Retinoic Acid ◽  
Nitric Oxide Synthase ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Α ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

Expression of a dominant negative retinoic acid receptor ? in Xenopus embryos leads to partial resistance to retinoic acid

1994 ◽  
Vol 203 (5) ◽  
pp. 254-265 ◽  
Author(s):  
Darrin Paul Smith ◽  
Clive Scott Mason ◽  
Elizabeth Jones ◽  
Robert Old
Keyword(s):  
Retinoic Acid ◽  
Partial Resistance ◽  
Retinoic Acid Receptor ◽  
Dominant Negative ◽  
Acid Receptor ◽  
Xenopus Embryos

scholarly journals Apoptosis Induction by Retinoids in Eosinophilic Leukemia Cells: Implication of Retinoic Acid Receptor-α Signaling in All-Trans-Retinoic Acid Hypersensitivity

2006 ◽  
Vol 66 (12) ◽  
pp. 6336-6344 ◽  
Author(s):  
Carine Robert ◽  
Laurent Delva ◽  
Nicole Balitrand ◽  
Sarolta Nahajevszky ◽  
Tamàs Masszi ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Leukemia Cells ◽  
Apoptosis Induction ◽  
Acid Receptor ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Retinoic Acid Receptor Α

Identification of Highly Potent Retinoic Acid Receptor α-Selective Antagonists

1997 ◽  
Vol 40 (16) ◽  
pp. 2445-2451 ◽  
Author(s):  
Min Teng ◽  
Tien T. Duong ◽  
Alan T. Johnson ◽  
Elliott S. Klein ◽  
Liming Wang ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Selective Antagonists ◽  
Retinoic Acid Receptor Α
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