RAS induced senescence of skin keratinocytes is mediated through Rho‐associated protein kinase (ROCK)

2021 ◽  
Author(s):  
Alex J. Lee ◽  
Elise Fraser ◽  
Brittany Flowers ◽  
Jee Kim ◽  
Kenneth Wong ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Skin Keratinocytes

scholarly journals AMP-activated Protein Kinase Contributes to UV- and H2O2-induced Apoptosis in Human Skin Keratinocytes

2008 ◽  
Vol 283 (43) ◽  
pp. 28897-28908 ◽  
Author(s):  
Cong Cao ◽  
Shan Lu ◽  
Rebecca Kivlin ◽  
Brittany Wallin ◽  
Elizabeth Card ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Human Skin ◽  
Skin Keratinocytes ◽  
Induced Apoptosis ◽  
Amp Activated Protein Kinase

scholarly journals AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes.

2010 ◽  
Vol 285 (19) ◽  
pp. 14842.2-14842 ◽  
Author(s):  
Cong Cao ◽  
Shan Lu ◽  
Rebecca Kivlin ◽  
Brittany Wallin ◽  
Elizabeth Card ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Human Skin ◽  
Skin Keratinocytes ◽  
Induced Apoptosis ◽  
Amp Activated Protein Kinase

scholarly journals Src Family Kinases Phosphorylate Protein Kinase C δ on Tyrosine Residues and Modify the Neoplastic Phenotype of Skin Keratinocytes

2002 ◽  
Vol 277 (14) ◽  
pp. 12318-12323 ◽  
Author(s):  
Elizabeth Joseloff ◽  
Christophe Cataisson ◽  
Heather Aamodt ◽  
Henrietta Ocheni ◽  
Peter Blumberg ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Src Family Kinases ◽  
Tyrosine Residues ◽  
Neoplastic Phenotype ◽  
Kinase C ◽  
Skin Keratinocytes

A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B

2001 ◽  
Vol 353 (3) ◽  
pp. 735
Author(s):  
K. PEYROLLIER ◽  
E. HAJDUCH ◽  
A. GRAY ◽  
G. J. LITHERLAND ◽  
A. R. PRESCOTT ◽  
...  
Keyword(s):  
Growth Factor ◽  
Protein Kinase ◽  
Actin Cytoskeleton ◽  
Protein Kinase B

Early signalling events of autophagy

2013 ◽  
Vol 55 ◽  
pp. 1-15 ◽  
Author(s):  
Laura E. Gallagher ◽  
Edmond Y.W. Chan
Keyword(s):  
Protein Kinase ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Mammalian Cells ◽  
Mammalian Target Of Rapamycin ◽  
Interacting Protein ◽  
The Core ◽  
Autophagy Gene ◽  
Autophagy Induction ◽  
Cellular Pathways

Autophagy is a conserved cellular degradative process important for cellular homoeostasis and survival. An early committal step during the initiation of autophagy requires the actions of a protein kinase called ATG1 (autophagy gene 1). In mammalian cells, ATG1 is represented by ULK1 (uncoordinated-51-like kinase 1), which relies on its essential regulatory cofactors mATG13, FIP200 (focal adhesion kinase family-interacting protein 200 kDa) and ATG101. Much evidence indicates that mTORC1 [mechanistic (also known as mammalian) target of rapamycin complex 1] signals downstream to the ULK1 complex to negatively regulate autophagy. In this chapter, we discuss our understanding on how the mTORC1–ULK1 signalling axis drives the initial steps of autophagy induction. We conclude with a summary of our growing appreciation of the additional cellular pathways that interconnect with the core mTORC1–ULK1 signalling module.

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