Long-term effects of rasagiline and the natural history of treated Parkinson's disease

2016 ◽  
Vol 31 (10) ◽  
pp. 1489-1496 ◽  
Author(s):  
Olivier Rascol ◽  
Robert A. Hauser ◽  
Fabrizio Stocchi ◽  
Cheryl J. Fitzer-Attas ◽  
Yulia Sidi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Natural History ◽  
Long Term Effects ◽  
History Of

scholarly journals Natural history of lung function over one year in patients with Parkinson's disease

2021 ◽  
Vol 182 ◽  
pp. 106396
Author(s):  
David A. Kaminsky ◽  
Donald G. Grosset ◽  
Deena M. Kegler-Ebo ◽  
Salvador Cangiamilla ◽  
Michael Klingler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lung Function ◽  
Natural History ◽  
History Of ◽  
One Year

scholarly journals The natural history of treated Parkinson's disease in an incident, community based cohort

2011 ◽  
Vol 82 (10) ◽  
pp. 1112-1118 ◽  
Author(s):  
J. R. Evans ◽  
S. L. Mason ◽  
C. H. Williams-Gray ◽  
T. Foltynie ◽  
C. Brayne ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Natural History ◽  
Community Based ◽  
History Of

Nationwide Multicenter Prospective Study on the Long-Term Effects of Bromocriptine for Parkinson's Disease

1997 ◽  
Vol 38 (2) ◽  
pp. 37-49 ◽  
Author(s):  
Norio Ogawa ◽  
Ichiro Kanazawa ◽  
Hisayuki Kowa ◽  
Sadako Kuno ◽  
Yoshikuni Mizuno ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Study ◽  
Long Term Effects ◽  
Multicenter Prospective Study

Long-Term Effects of Medical and Surgical Treatments on Parkinson's Disease

1994 ◽  
Vol 62 (1-4) ◽  
pp. 85-89
Author(s):  
Fiacro Jimenez ◽  
Francisco Velasco ◽  
Marcos Velasco ◽  
Ana Luisa Velasco
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Effects ◽  
Surgical Treatments

scholarly journals Longitudinal prediction of falls and near falls frequencies in Parkinson’s disease: a prospective cohort study

2020 ◽  
Author(s):  
Beata Lindholm ◽  
Christina Brogårdh ◽  
Per Odin ◽  
Peter Hagell
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prospective Cohort ◽  
Prediction Models ◽  
Evidence Base ◽  
History Of ◽  
Short And Long Term ◽  
Near Falls ◽  
Short Time

Abstract Introduction and objective Several prediction models for falls/near falls in Parkinson’s disease (PD) have been proposed. However, longitudinal predictors of frequency of falls/near falls are poorly investigated. Therefore, we aimed to identify short- and long-term predictors of the number of falls/near falls in PD. Methods A prospective cohort of 58 persons with PD was assessed at baseline (mean age and PD duration, 65 and 3.2 years, respectively) and 3.5 years later. Potential predictors were history of falls and near falls, comfortable gait speed, freezing of gate, dyskinesia, retropulsion, tandem gait (TG), pain, and cognition (Mini-Mental State Exam, MMSE). After each assessment, the participants registered a number of falls/near falls during the following 6 months. Multivariate Poisson regression was used to identify short- and long-term predictors of a number of falls/near falls. Results Baseline median (q1–q3) motor (UPDRS) and MMSE scores were 10 (6.75–14) and 28.5 (27–29), respectively. History of falls was the only significant short-time predictor [incidence rate ratio (IRR), 15.17] for the number of falls/near falls during 6 months following baseline. Abnormal TG (IRR, 3.77) and lower MMSE scores (IRR, 1.17) were short-term predictors 3.5 years later. Abnormal TG (IRR, 7.79) and lower MMSE scores (IRR, 1.49) at baseline were long-term predictors of the number of falls/near falls 3.5 years later. Conclusion Abnormal TG and MMSE scores predict the number of falls/near falls in short and long term, and may be indicative of disease progression. Our observations provide important additions to the evidence base for clinical fall prediction in PD.

scholarly journals Long duration response in Parkinson’s disease: levodopa revisited

Brain ◽  
2020 ◽  
Vol 143 (8) ◽  
pp. 2332-2335
Author(s):  
Werner Poewe ◽  
Alberto J Espay
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Natural History ◽  
Motor Symptoms ◽  
Long Duration ◽  
History Of

This scientific commentary refers to ‘Natural history of motor symptoms in Parkinson’s disease and the long-duration response to levodopa’, by Cilia etal. (doi:10.1093/brain/awaa181).

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