MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain

2004 ◽  
Vol 51 (5) ◽  
pp. 913-923 ◽  
Author(s):  
Nathan McDannold ◽  
Natalia Vykhodtseva ◽  
Ferenc A. Jolesz ◽  
Kullervo Hynynen
Keyword(s):  
Brain Tissue ◽  
Blood Brain Barrier ◽  
Tissue Damage ◽  
Brain Barrier ◽  
Rabbit Brain ◽  
Thermally Induced ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Brain Barrier Disruption ◽  
Brain Tissue Damage

Osmotic blood-brain barrier disruption in the posterior fossa of the dog

1981 ◽  
Vol 55 (5) ◽  
pp. 742-748 ◽  
Author(s):  
Edward A. Neuwelt ◽  
Mark Glasberg ◽  
Jan Diehl ◽  
Eugene P. Frenkel ◽  
Peggy Barnett
Keyword(s):  
Vertebral Artery ◽  
Brain Tissue ◽  
Blood Brain Barrier ◽  
Posterior Fossa ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Catheter Technique ◽  
Brain Barrier Disruption

✓ Transient reversible osmotic blood-brain barrier disruption was produced in the posterior fossa of 33 dogs. A percutaneous catheter technique was used for the infusion of hypertonic mannitol into the vertebral artery. Neither the catheter technique nor the osmotic barrier modification resulted in interference with brain-stem function in most animals. The degree of barrier modification achieved by osmotic disruption in the posterior fossa is similar to that previously described for barrier modification of the supratentorial parenchyma. Methotrexate delivered to the brain via the vertebral artery resulted in a drug concentration of 100 to 300 ng/gm brain tissue. When the same amount of drug was given following osmotic blood-brain barrier disruption, brain tissue contained 1100 to 5000 ng of methotrexate/gm of brain tissue. Finally, the adequacy of the blood-brain barrier modification in the posterior fossa was shown to be quantifiable by the amount of enhancement on computerized tomographic scans.

scholarly journals Transcriptomic Response of Brain Tissue to Focused Ultrasound-Mediated Blood-Brain Barrier Disruption Depends Strongly on Anesthesia

2020 ◽  
Author(s):  
A.S. Mathew ◽  
C.M. Gorick ◽  
E.A. Thim ◽  
W.J. Garrison ◽  
A.L. Klibanov ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Blood Brain Barrier ◽  
Tissue Repair ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Transcriptomic Response ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Gene Sets ◽  
Brain Barrier Disruption

AbstractFocused ultrasound (FUS) mediated blood brain barrier disruption (BBBD) is a promising strategy for the targeted delivery of systemically-administered therapeutics to the central nervous system (CNS). Pre-clinical investigations of BBBD have been performed on different anesthetic backgrounds; however, the potential influence of the choice of anesthetic on the molecular response to BBBD is unknown, despite its potential to critically affect interpretation of experimental therapeutic outcomes. Here, using bulk RNA sequencing approaches, we comprehensively examined the transcriptomic response of both normal brain tissue and brain tissue exposed to FUS-induced BBBD in mice anesthetized with either isoflurane with medical air (Iso) or ketamine/dexmedetomidine (KD). In normal murine brain tissue, Iso alone elicited minimal differential gene expression (DGE) and repressed pathways associated with neuronal signaling. KD alone, however, led to massive DGE and enrichment of pathways associated with protein synthesis. In brain tissue exposed to BBBD (1 MHz, 0.5 Hz pulse repetition frequency, 0.4 MPa peak-negative pressure), we systematically evaluated the relative effects of anesthesia, microbubbles, and FUS on the transcriptome. Of particular interest, we observed that gene sets associated with sterile inflammatory responses and cell-cell junctional activity were induced by BBBD, regardless of the choice of anesthesia. Meanwhile, gene sets associated with metabolism, platelet activity, tissue repair, and signaling pathways, were differentially affected by BBBD, with a strong dependence on the anesthetic. We conclude that the underlying transcriptomic response to FUS-mediated BBBD may be powerfully influenced by anesthesia. These findings raise considerations for the translation of FUS-BBBD delivery approaches that impact, in particular, metabolism, tissue repair, and intracellular signaling.

scholarly journals Transcriptomic response of brain tissue to focused ultrasound‐mediated blood–brain barrier disruption depends strongly on anesthesia

2020 ◽  
Author(s):  
Alexander S. Mathew ◽  
Catherine M. Gorick ◽  
E. Andrew Thim ◽  
William J. Garrison ◽  
Alexander L. Klibanov ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Brain Barrier ◽  
Transcriptomic Response ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption

Ultraearly reperfusion induces blood brain barrier disruption during focal ischemia in rats

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S274-S274
Author(s):  
Johannes Woitzik ◽  
Axel Hohenstein ◽  
Nina Weinzierl ◽  
Lothar Schilling
Keyword(s):  
Blood Brain Barrier ◽  
Focal Ischemia ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption

The treatment of brain metastasis from breast cancer, role of blood-brain barrier disruption and early experience with trastuzumab

Therapy ◽  
2006 ◽  
Vol 3 (1) ◽  
pp. 97-112 ◽  
Author(s):  
Rose Marie Tyson ◽  
Dale F Kraemer ◽  
Matthew A Hunt ◽  
Leslie L Muldoon ◽  
Peter Orbay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Blood Brain Barrier ◽  
Early Experience ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption

Blood-brain Barrier Disruption Leads to Postoperative Cognitive Dysfunction

2018 ◽  
Vol 14 (4) ◽  
pp. 359-367 ◽  
Author(s):  
Bin Wang ◽  
Siyuan Li ◽  
Xipeng Cao ◽  
Xinghui Dou ◽  
Jingzhu Li ◽  
...  
Keyword(s):  
Cognitive Dysfunction ◽  
Blood Brain Barrier ◽  
Postoperative Cognitive Dysfunction ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption
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