scholarly journals Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy

2007 ◽  
Vol 58 (5) ◽  
pp. 880-885 ◽  
Author(s):  
Andrew M. Blamire ◽  
Sarah Cader ◽  
Martin Lee ◽  
Jackie Palace ◽  
Paul M. Matthews
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Axonal Damage ◽  
Resonance Spectroscopy ◽  
Multiple Sclerosis Patients

Putting Magnetic Resonance Spectroscopy Studies in Context: Axonal Damage and Disability in Multiple Sclerosis

1998 ◽  
Vol 18 (03) ◽  
pp. 327-336 ◽  
Author(s):  
P. Matthews ◽  
N. De Stefano ◽  
S. Narayanan ◽  
G. Francis ◽  
J. Wolinsky ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Axonal Damage ◽  
Resonance Spectroscopy ◽  
Spectroscopy Studies

scholarly journals Axonal Damage in Multiple Sclerosis Patients with High versus Low Expanded Disability Status Scale Score

2004 ◽  
Vol 31 (2) ◽  
pp. 225-228 ◽  
Author(s):  
Steven D. Brass ◽  
Sridar Narayanan ◽  
Jack P. Antel ◽  
Yves Lapierre ◽  
Louis Collins ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Magnetic Resonance ◽  
Disease Process ◽  
Resonance Spectroscopy ◽  
Lesion Volume ◽  
Spinal Cord Atrophy ◽  
Neuronal Marker ◽  
Multiple Sclerosis Patients

AbstractBackground:The pathophysiological basis for differences in disability in patients with multiple sclerosis is unclear.Methods:We used magnetic resonance imaging to examine whether differences in disability in cohorts of multiple sclerosis patients with similar T2-weighted lesion volume and disease duration were associated with a more destructive disease process in the more disabled patients.Results:The benign and severely disabled groups had similar brain atrophy metrics and similar decreases of the neuronal marker, N-acetylaspartate, in the normal appearing white matter of the cerebrum on magnetic resonance spectroscopy examination in vivo. The severely disabled cohort had more spinal cord atrophy.Conclusion:The dissociation of spinal cord atrophy and cerebral atrophy between these two groups suggests that the difference between the more benign and more disabled groups cannot be explained by a more aggressive pathological process that is affecting the entire neuroaxis in a homogeneous fashion.

Sign in / Sign up

Export Citation Format

Share Document