Erratum to: Helms, dathe, kallenberg and dechent, high-resolution maps of magnetization transfer with inherent correction for rf inhomogeneity and T
                        1
 relaxation obtained from 3D FLASH MRI. Magn Reson Med 2008 Dec;60(6):1396-1407

Magnetization transfer imaging (MT) may have considerable promise for early detection and monitoring of subtle brain changes before they are apparent on conventional magnetic resonance images. At 3 Tesla (T), MT affords higher resolution and increased tissue contrast associated with macromolecules. The reliability and reproducibility of a new high-resolution MT strategy were assessed in brain images acquired from 9 healthy subjects. Repeated measures were taken for 12 brain regions of interest (ROIs): genu, splenium, and the left and right hemispheres of the hippocampus, caudate, putamen, thalamus, and cerebral white matter. Spearman's correlation coefficient, coefficient of variation, and intraclass correlation coefficient (ICC) were computed. Multivariate mixed-effects regression models were used to fit the mean ROI values and to test the significance of the effects due to region, subject, observer, time, and manual repetition. A sensitivity analysis of various model specifications and the corresponding ICCs was conducted. Our statistical methods may be generalized to many similar evaluative studies of the reliability and reproducibility of various imaging modalities.

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High Resolution, Magnetization Transfer Saturation, Variable Flip Angle, Time-of-Flight MRA in the Detection of Intracranial Vascular Stenoses

Journal of Computer Assisted Tomography ◽

10.1097/00004728-199509000-00003 ◽

1995 ◽

Vol 19 (5) ◽

pp. 700-706 ◽

Cited By ~ 35

Author(s):

Angela Dagirmanjian ◽

Jeffrey S. Ross ◽

Nancy Obuchowski ◽

Jonathan S. Lewin ◽

Jean A. Tkach ◽

...

Keyword(s):

High Resolution ◽

Magnetization Transfer ◽

Time Of Flight ◽

Flip Angle ◽

Variable Flip Angle

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High-resolution magnetization transfer MRI in patients with cervical spondylotic myelopathy

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2018.02.023 ◽

2018 ◽

Vol 51 ◽

pp. 57-61 ◽

Cited By ~ 2

Author(s):

Linda I. Suleiman ◽

Kenneth A. Weber ◽

Brett D. Rosenthal ◽

Surabhi A. Bhatt ◽

Jason W. Savage ◽

...

Keyword(s):

High Resolution ◽

Cervical Spondylotic Myelopathy ◽

Magnetization Transfer ◽

Magnetization Transfer Mri

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Contrast-free high-resolution 3D magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization

Magnetic Resonance Materials in Physics Biology and Medicine ◽

10.1007/s10334-020-00833-9 ◽

2020 ◽

Vol 33 (5) ◽

pp. 627-640

Author(s):

Karina López ◽

Radhouene Neji ◽

Rahul K. Mukherjee ◽

John Whitaker ◽

Alkystis Phinikaridou ◽

...

Keyword(s):

High Resolution ◽

Spatial Variability ◽

Motion Correction ◽

Magnetization Transfer ◽

Free Breathing ◽

Magnetization Transfer Ratio ◽

Swine Model ◽

Coronary Vein ◽

Coronary Veins ◽

Vessel Sharpness

Abstract Objective To develop a three-dimensional (3D) high-resolution free-breathing magnetization transfer ratio (MTR) sequence for contrast-free assessment of myocardial infarct and coronary vein anatomy. Materials and methods Two datasets with and without off-resonance magnetization transfer preparation were sequentially acquired to compute MTR. 2D image navigators enabled beat-to-beat translational and bin-to-bin non-rigid motion correction. Two different imaging sequences were explored. MTR scar localization was compared against 3D late gadolinium enhancement (LGE) in a porcine model of myocardial infarction. MTR variability across the left ventricle and vessel sharpness in the coronary veins were evaluated in healthy human subjects. Results A decrease in MTR was observed in areas with LGE in all pigs (non-infarct: 25.1 ± 1.7% vs infarct: 16.8 ± 1.9%). The average infarct volume overlap on MTR and LGE was 62.5 ± 19.2%. In humans, mean MTR in myocardium was between 37 and 40%. Spatial variability was between 15 and 20% of the mean value. 3D whole heart MT-prepared datasets enabled coronary vein visualization with up to 8% improved vessel sharpness for non-rigid compared to translational motion correction. Discussion MTR and LGE showed agreement in infarct detection and localization in a swine model. Free-breathing 3D MTR maps are feasible in humans but high spatial variability was observed. Further clinical studies are warranted.

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