Effects of desipramine and MK-801 on components of muricidal behaviour in olfactory bulbectomized rats: An application of incisor-cutting animal model

2004 ◽  
Vol 34 (3) ◽  
pp. 136-143
Author(s):  
Ying-Jui Ho ◽  
Hung Hsuchou ◽  
Kuang-Ho Chen ◽  
Hao-Ai Shui ◽  
Mei-Yun Tai ◽  
...  
Keyword(s):  
Animal Model ◽  
Mk 801

scholarly journals Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1026
Author(s):  
Kristina Holubova ◽  
Marketa Chvojkova ◽  
Barbora Hrcka Krausova ◽  
Vojtech Vyklicky ◽  
Eva Kudova ◽  
...  
Keyword(s):  
Animal Model ◽  
Nmda Receptor ◽  
Neuroactive Steroids ◽  
Stress Exposure ◽  
Mk 801 ◽  
Receptor Modulator ◽  
Receptor Modulation ◽  
Antipsychotic Effect ◽  
Response To Stress ◽  
Systemic Application

Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We investigated the antipsychotic effect of two neuroactive steroids in an animal model of schizophrenia induced by systemic application of MK-801. The neuroactive steroids differ in their mechanism of action at NMDARs. MS-249 is positive, while PA-Glu is a negative allosteric NMDAR modulator. We hypothesized that the positive NMDA receptor modulator would attenuate deficits caused by MK-801 co-application more effectively than PA-Glu. The rats were tested in a battery of tests assessing spontaneous locomotion, anxiety and cognition. Contrary to our expectations, PA-Glu exhibited a superior antipsychotic effect to MS-249. The performance of MS-249-treated rats in cognitive tests differed depending on the level of stress the rats were exposed to during test sessions. In particular, with the increasing severity of stress exposure, the performance of animals worsened. Our results demonstrate that enhancement of NMDAR function may result in unspecific behavioral responses. Positive NMDAR modulation can influence other neurobiological processes besides memory formation, such as anxiety and response to stress.

scholarly journals Effects of sodium nitroprusside in the acute dizocilpine (MK-801) animal model of schizophrenia

2019 ◽  
Vol 147 ◽  
pp. 140-147
Author(s):  
Xiujuan Wang ◽  
Shuang Ding ◽  
Yanli Lu ◽  
Zhiqiang Jiao ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Animal Model ◽  
Sodium Nitroprusside ◽  
Mk 801

Establishment of a schizophrenic animal model through chronic administration of MK-801 in infancy and social isolation in childhood

2017 ◽  
Vol 46 ◽  
pp. 135-143 ◽  
Author(s):  
Weiqing Liu ◽  
Xiuyan Wang ◽  
Wenjuan Hong ◽  
Dong Wang ◽  
Xiaogang Chen
Keyword(s):  
Animal Model ◽  
Social Isolation ◽  
Chronic Administration ◽  
Mk 801

Antiepileptic and behavioural actions of MK-801 in an animal model of spontaneous absence epilepsy

1989 ◽  
Vol 3 (2) ◽  
pp. 178-181 ◽  
Author(s):  
B.W.M.M Peeters ◽  
C.M Van Rijn ◽  
E.L.J.M Van Luijtelaar ◽  
A.M.L Coenen
Keyword(s):  
Animal Model ◽  
Absence Epilepsy ◽  
Mk 801

scholarly journals Effect of dizocilpine (MK-801) on the working memory of rats on a three-panel runway apparatus

2018 ◽  
Vol 7 (12) ◽  
pp. 2373
Author(s):  
Naveen Kumar ◽  
Navin Budania ◽  
Arka Mondal ◽  
Sana Tafseer ◽  
Siddarth Ahuja ◽  
...  
Keyword(s):  
Working Memory ◽  
Animal Model ◽  
Nmda Receptor ◽  
Animal Models ◽  
Receptor Antagonist ◽  
Cognitive Deficits ◽  
Latency Period ◽  
Nmda Receptor Antagonist ◽  
Memory Errors ◽  
Mk 801

Background: Understanding the processes underlying cognitive functions is a prerequisite to develop strategies for the treatment of cognitive deficits. There is a great need for valid animal models for investigating the cognitive enhancing effects of potential therapeutics. Many studies have investigated animal models of cognitive deficits by using animals treated with compounds that compromise cognitive abilities. Glutamate, an excitatory neurotransmitter and abundantly distributed in the central nervous system is involved in memory processes through N-methyl-d-aspartate (NMDA) receptors. The behavioural consequences of blocking the NMDA receptor provide the rationale for cognitive impairment as an animal model for the cognitive deficits associated with dementia. Authors investigated the effect of dizocilpine (MK-801), an NMDA-receptor antagonist (non-competitive) on the working memory in rats using the three-panel runway apparatus.Methods: Total 24 trained male albino rats were randomly divided into 4 groups of 6 animals each. Varying doses of MK-801 were administered to the animals. Working memory errors and latency periods were evaluated on the three panel Runway apparatus.Results: Treatment with MK-801 at the dose of 0.03mg/ kg did not result in any significant change in working memory errors or latency period in comparison to saline control. MK-801 treatment at dose of 0.1mg/kg and 0.3mg/kg resulted in a significant increase in the number of working memory errors and latency period as compared to control.Conclusions: Authors conclude that MK-801 treatment in the dose of 0.1mg/ kg and 0.3mg/kg resulted in working memory deficits on the three-panel runway apparatus. Rats with cognitive deficits induced by the prototypical N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 may provide a relevant animal model of dementia based on the mechanistic approach of blocking NMDA/glutamatergic signalling.

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