scholarly journals Coaxial electrospun membranes of poly(ε‐caprolactone)/poly(lactic acid) with reverse core‐shell structures loaded with curcumin as tunable drug delivery systems

2021 ◽  
Author(s):  
Gianluca Viscusi ◽  
Elena Lamberti ◽  
Vittoria Vittoria ◽  
Giuliana Gorrasi
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Shell Structures ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Electrospun Membranes

Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

2014 ◽  
Vol 2 (20) ◽  
pp. 3133-3141 ◽  
Author(s):  
Claire Jouannin ◽  
Corine Tourné-Péteilh ◽  
Vincent Darcos ◽  
Tahmer Sharkawi ◽  
Jean-Marie Devoisselle ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

scholarly journals Development of paclitaxel-loaded poly(lactic acid)/hydroxyapatite core–shell nanoparticles as a stimuli-responsive drug delivery system

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Sungho Lee ◽  
Tatsuya Miyajima ◽  
Ayae Sugawara-Narutaki ◽  
Katsuya Kato ◽  
Fukue Nagata
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Delivery Systems ◽  
Ph Sensitivity ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Shell Nanoparticles ◽  
The Core ◽  
Core Shell Nanoparticles

Biodegradable nanoparticles have been well studied as biocompatible delivery systems. Nanoparticles of less than 200 nm in size can facilitate the passive targeting of drugs to tumour tissues and their accumulation therein via the enhanced permeability and retention (EPR) effect. Recent studies have focused on stimuli-responsive drug delivery systems (DDS) for improving the effectiveness of chemotherapy; for example, pH-sensitive DDS depend on the weakly acidic and neutral extracellular pH of tumour and normal tissues, respectively. In our previous work, core–shell nanoparticles composed of the biodegradable polymer poly(lactic acid) (PLA) and the widely used inorganic biomaterial hydroxyapatite (HAp, which exhibits pH sensitivity) were prepared using a surfactant-free method. These PLA/HAp core–shell nanoparticles could load 750 wt% of a hydrophobic model drug. In this work, the properties of the PLA/HAp core–shell nanoparticles loaded with the anti-cancer drug paclitaxel (PTX) were thoroughly investigated in vitro . Because the PTX-containing nanoparticles were approximately 80 nm in size, they can be expected to facilitate efficient drug delivery via the EPR effect. The core–shell nanoparticles were cytotoxic towards cancer cells (4T1). This was due to the pH sensitivity of the HAp shell, which is stable in neutral conditions and dissolves in acidic conditions. The cytotoxic activity of the PTX-loaded nanoparticles was sustained for up to 48 h, which was suitable for tumour growth inhibition. These results suggest that the core–shell nanoparticles can be suitable drug carriers for various water-insoluble drugs.

Drug delivery systems using sandwich configurations of electrospun poly(lactic acid) nanofiber membranes and ibuprofen

2013 ◽  
Vol 33 (7) ◽  
pp. 4002-4008 ◽  
Author(s):  
Ana Paula Serafini Immich ◽  
Manuel Lis Arias ◽  
Núria Carreras ◽  
Rafael Luís Boemo ◽  
José Antonio Tornero
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid ◽  
Nanofiber Membranes

Poly(Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems

2013 ◽  
Vol 21 (4) ◽  
pp. 1064-1071 ◽  
Author(s):  
Nita Tudorachi ◽  
Rodica Lipsa ◽  
Cornelia Vasile ◽  
Fanica Mustata
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Aspartic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

scholarly journals Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers

2018 ◽  
Vol 5 (7) ◽  
pp. 180320 ◽  
Author(s):  
Duanhua Cai ◽  
Jingqian Fan ◽  
Shibin Wang ◽  
Ruimin Long ◽  
Xia Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Methylene Chloride ◽  
Drug Carrier ◽  
Delivery Systems ◽  
Core Shell ◽  
Layer By Layer ◽  
Shell Nanoparticles ◽  
Uniform Size ◽  
Covalent Bonds

Layer-by-layer (LbL) self-assembly is the technology used in intermolecular static electricity, hydrogen bonds, covalent bonds and other polymer interactions during film assembling. This technology has been widely studied in the drug carrier field. Given their use in drug delivery systems, the biocompatibility of these potential compounds should be addressed. In this work, the primary biocompatibility of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) [PLGA-(PLO/fucoidan)] core–shell nanoparticles (NPs) was investigated. Atomic force microscopy revealed the PLGA-(PLO/Fucoidan) 4 NPs to be spherical, with a uniform size distribution and a smooth surface, and the NPs were stable in physiological saline. The residual amount of methylene chloride was further determined by headspace gas chromatography, in which the organic solvent can be volatilized during preparation. Furthermore, cell viability, acridine orange/ethidium bromide staining, haemolysis and mouse systemic toxicity were all assessed to show that PLGA-(PLO/fucoidan) 4 NPs were biocompatible with cells and mice. Therefore, these NPs are expected to have potential applications in future drug delivery systems.

Sign in / Sign up

Export Citation Format

Share Document