Drug delivery systems using sandwich configurations of electrospun poly(lactic acid) nanofiber membranes and ibuprofen

2013 ◽  
Vol 33 (7) ◽  
pp. 4002-4008 ◽  
Author(s):  
Ana Paula Serafini Immich ◽  
Manuel Lis Arias ◽  
Núria Carreras ◽  
Rafael Luís Boemo ◽  
José Antonio Tornero
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid ◽  
Nanofiber Membranes

Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

2014 ◽  
Vol 2 (20) ◽  
pp. 3133-3141 ◽  
Author(s):  
Claire Jouannin ◽  
Corine Tourné-Péteilh ◽  
Vincent Darcos ◽  
Tahmer Sharkawi ◽  
Jean-Marie Devoisselle ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

Poly(Lactic Acid)-co-Aspartic Acid Copolymers: Possible Utilization in Drug Delivery Systems

2013 ◽  
Vol 21 (4) ◽  
pp. 1064-1071 ◽  
Author(s):  
Nita Tudorachi ◽  
Rodica Lipsa ◽  
Cornelia Vasile ◽  
Fanica Mustata
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Aspartic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

scholarly journals Development of paclitaxel-loaded poly(lactic acid)/hydroxyapatite core–shell nanoparticles as a stimuli-responsive drug delivery system

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Sungho Lee ◽  
Tatsuya Miyajima ◽  
Ayae Sugawara-Narutaki ◽  
Katsuya Kato ◽  
Fukue Nagata
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Delivery Systems ◽  
Ph Sensitivity ◽  
Poly Lactic Acid ◽  
Core Shell ◽  
Stimuli Responsive ◽  
Shell Nanoparticles ◽  
The Core ◽  
Core Shell Nanoparticles

Biodegradable nanoparticles have been well studied as biocompatible delivery systems. Nanoparticles of less than 200 nm in size can facilitate the passive targeting of drugs to tumour tissues and their accumulation therein via the enhanced permeability and retention (EPR) effect. Recent studies have focused on stimuli-responsive drug delivery systems (DDS) for improving the effectiveness of chemotherapy; for example, pH-sensitive DDS depend on the weakly acidic and neutral extracellular pH of tumour and normal tissues, respectively. In our previous work, core–shell nanoparticles composed of the biodegradable polymer poly(lactic acid) (PLA) and the widely used inorganic biomaterial hydroxyapatite (HAp, which exhibits pH sensitivity) were prepared using a surfactant-free method. These PLA/HAp core–shell nanoparticles could load 750 wt% of a hydrophobic model drug. In this work, the properties of the PLA/HAp core–shell nanoparticles loaded with the anti-cancer drug paclitaxel (PTX) were thoroughly investigated in vitro . Because the PTX-containing nanoparticles were approximately 80 nm in size, they can be expected to facilitate efficient drug delivery via the EPR effect. The core–shell nanoparticles were cytotoxic towards cancer cells (4T1). This was due to the pH sensitivity of the HAp shell, which is stable in neutral conditions and dissolves in acidic conditions. The cytotoxic activity of the PTX-loaded nanoparticles was sustained for up to 48 h, which was suitable for tumour growth inhibition. These results suggest that the core–shell nanoparticles can be suitable drug carriers for various water-insoluble drugs.

New biodegradable polymers of L-lactic acid and aromatic hydroxy acids and their applications in drug delivery systems

1992 ◽  
Vol 81 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Kazumichi Imasaka ◽  
Masaru Yoshida ◽  
Hironobu Fukuzaki ◽  
Masaharu Asano ◽  
Minoru Kumakura ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Biodegradable Polymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Hydroxy Acids

scholarly journals Nanosized Minicells Generated by Lactic Acid Bacteria for Drug Delivery

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Huu Ngoc Nguyen ◽  
Santa Romero Jovel ◽  
Tu Hoang Khue Nguyen
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
The Body ◽  
Inorganic Nanoparticles ◽  
Microbial Infection ◽  
Clinical Stages

Nanotechnology has the ability to target specific areas of the body, controlling the drug release and significantly increasing the bioavailability of active compounds. Organic and inorganic nanoparticles have been developed for drug delivery systems. Many delivery systems are through clinical stages for development and market. Minicell, a nanosized cell generated by bacteria, is a potential particle for drug delivery because of its size, safety, and biodegradability. Minicells produced by bacteria could drive therapeutic agents against cancer, microbial infection, and other diseases by targeting. In addition, minicells generated by lactic acid bacteria being probiotics are more interesting than others because of their benefits like safety, immunological improvement, and biodegradation. This review aims to highlight the stages of development of nanoparticle for drug delivery and discuss their advantages and limitations to clarify minicells as a new opportunity for the development of potential nanoparticle for drug delivery.

Multifunctional-Dual Drug Delivery Poly-Lactic Acid Biocomposite Coating with Hydroxyapatite for Bone Implants

2018 ◽  
Vol 782 ◽  
pp. 212-217
Author(s):  
Ipek Karacan ◽  
Joshua Chou ◽  
Besim Ben-Nissan ◽  
Innocent J. Macha ◽  
Sophie Cazalbou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Poly Lactic Acid ◽  
Adverse Side Effects ◽  
New Novel ◽  
Metallic Implants ◽  
Ceramic Hydroxyapatite ◽  
Acid Coating ◽  
Dual Drug

The new novel implant designs include the functionality of advanced drug delivery systems in order to improve osteointegration and to inhibit the implant-related post-operative infections. In this research, Ti6Al4V metallic implants were coated with the multifunctional-dual slow drug delivery coating which includes a polymeric matrix system based on a poly-lactic acid thin film and a bioactive ceramic hydroxyapatite. This system consists of two different kinds of pharmaceuticals, which are gentamicin and simvastatin. It is reported in this paper that the simvastatin and gentamicin containing poly-lactic acid coating which was applied uniformly and successfully with and without hydroxyapatite microspheres. Most importantly, the release rate of drugs was controlled with PLA matrix and HAp microspheres which have different dissolution rates in order to prevent the high dosages causing adverse side-effects of drugs.

scholarly journals Structure-Processing-Property Relationship of Poly(Glycolic Acid) for Drug Delivery Systems 1: Synthesis and Catalysis

2010 ◽  
Vol 2010 ◽  
pp. 1-23 ◽  
Author(s):  
Vineet Singh ◽  
Meena Tiwari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Delivery Systems ◽  
Poly Lactic Acid ◽  
Depth Study ◽  
Ester Linkage ◽  
Synthetic Methodologies ◽  
Conventional Systems ◽  
Relationship Of

Till date, market is augmented with a huge number of improved drug delivery systems. The success in this area is basically due to biodegradable polymers. Although conventional systems of drug delivery utilizing the natural and semisynthetic polymers so long but synthetic polymer gains success in the controlled drug delivery area due to better degradation profile and controlled network and functionality. The polyesters are the most studied class group due the susceptible ester linkage in their backbone. The Poly(glycolic Acid) (PGA), Poly(lactic acid) (PLA), and Polylactide-co-glycolide (PLGA) are the best profiled polyesters and are most widely used in marketed products. These polymers, however, still are having drawbacks which failed them to be used in platform technologies like matrix systems, microspheres, and nanospheres in some cases. The common problems arose with these polymers are entrapment inefficiency, inability to degrade and release drugs with required profile, and drug instability in the microenvironment of the polymers. These problems are forcing us to develop new polymers with improved physicochemical properties. The present review gave us an insight in the various structural elements of Poly(glycolic acid), polyester, with in depth study. The first part of the review focuses on the result of studies related to synthetic methodologies and catalysts being utilized to synthesize the polyesters. However the author will also focus on the effect of processing methodologies but due some constraints those are not included in the preview of this part of review.

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