Glomerular filtration rate in children and young adults with haemato‐oncological disease and infection is best described by three‐compartment iohexol model

2021 ◽  
Author(s):  
Hiie Soeorg ◽  
Aveli Noortoots ◽  
Maarja Karu ◽  
Kadri Saks ◽  
Jana Lass ◽  
...  
Keyword(s):  
Young Adults ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Oncological Disease ◽  
Children And Young Adults

scholarly journals Glomerular filtration rate in children and young adults with haemato-oncological disease and infection is best described by three-compartmental iohexol model

2021 ◽  
Author(s):  
Hiie Soeorg ◽  
Aveli Noortoots ◽  
Maarja Karu ◽  
Kadri Saks ◽  
Jana Lass ◽  
...  
Keyword(s):  
Young Adults ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Population Pharmacokinetic Model ◽  
Filtration Rate ◽  
Pharmacokinetic Model ◽  
Population Pharmacokinetic ◽  
Oncological Disease ◽  
Children And Young Adults ◽  
Egfr Equation

Background. Children with cancer and infection may develop glomerular hyperfiltration (GH). With the aim to determine the prevalence of GH in children and young adults with haemato-oncological disease and infection we developed population pharmacokinetic model of iohexol. We further aimed to assess the accuracy of estimated glomerular filtration rate (eGFR) equations and single- or two-point measured GFR (mGFR) formulas compared with GFR based on iohexol clearance from our population pharmacokinetic model (iGFR). Procedure. Hospitalized patients (0.5-25 years) with haemato-oncological disease and infection were included if their eGFR was ≥80 mL/min/1.73 m2 at the screening visit. Iohexol plasma concentrations were described by population pharmacokinetic model. Bias, precision and accuracy of 23 eGFR equations and 18 mGFR formulas were calculated. Results. Total of 32 iohexol administrations was performed in 28 patients. Median (range) eGFR was 136 (74-234) mL/min/1.73 m2 and age 15.1 (0.8-26.0) years. Three-compartment model with allometric scaling of central, one peripheral compartment and clearance (with power 0.75) to weight fitted the best. Median (range) iGFR was 103 (68-140) mL/min/1.73 m2. All except one eGFR equation overestimated GFR. Lund-Malmö revised eGFR equation performed the best, followed by Gao equation. Of single- or two-point mGFR formulas 15 overestimated iGFR. Modified Jacobsson formula at 5.5 h performed the best, followed by Fleming formula at 3 h. Conclusions. In children and young adults with haemato-oncological disease and infection renal function is best described by iohexol clearance from three-compartmental pharmacokinetic model, while eGFR equations and single- and two-point mGFR formulas overestimate iGFR.

scholarly journals Utility of kinetic glomerular filtration rate for predicting severe persistent acute kidney injury in critically ill children and young adults

Kidney360 ◽  
2021 ◽  
pp. 10.34067/KID.0006892020
Author(s):  
Shina Menon ◽  
Rajit K Basu ◽  
Matthew F Barhight ◽  
Stuart L Goldstein ◽  
Katja M Gist
Keyword(s):  
Acute Kidney Injury ◽  
Young Adults ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Critically Ill ◽  
Filtration Rate ◽  
Kidney Injury ◽  
Critically Ill Children ◽  
Early Access ◽  
Children And Young Adults

This is an Early Access article. Please select the PDF button, above, to view it.

Cystatin C in assessment of glomerular filtration rate in children and young adults suffering from cancer

2013 ◽  
Vol 34 (6) ◽  
pp. 609-614 ◽  
Author(s):  
Mark C. Barnfield ◽  
Maria T. Burniston ◽  
Una Reid ◽  
Alastair M. Graham ◽  
Mick Henderson ◽  
...  
Keyword(s):  
Young Adults ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Cystatin C ◽  
Filtration Rate ◽  
Children And Young Adults

scholarly journals The Influence of Salt Loading on Glomerular Filtration Rate and Blood Pressure Variability in Healthy Young Adults

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Alex Barnett ◽  
Matthew Babcock ◽  
Joseph Watso ◽  
Kamila Migdal ◽  
William Farqhuar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Blood Pressure Variability ◽  
Filtration Rate ◽  
Salt Loading

scholarly journals A new equation to estimate the glomerular filtration rate in children, adolescents and young adults

2013 ◽  
Vol 29 (5) ◽  
pp. 1082-1091 ◽  
Author(s):  
L. Hoste ◽  
L. Dubourg ◽  
L. Selistre ◽  
V. C. De Souza ◽  
B. Ranchin ◽  
...  
Keyword(s):  
Young Adults ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Adolescents And Young Adults ◽  
New Equation
Sign in / Sign up

Export Citation Format

Share Document