Non-invasive approach to prenatal diagnosis from maternal peripheral blood

1992 ◽  
Vol 12 (6) ◽  
pp. 547-548 ◽  
Author(s):  
Y.-M. D. Lo ◽  
J. S. Wainscoat ◽  
K. A. Fleming
Keyword(s):  
Prenatal Diagnosis ◽  
Peripheral Blood ◽  
Invasive Approach ◽  
Non Invasive ◽  
Maternal Peripheral Blood

Prenatal Diagnosis Using Fetal Cells Isolated From Maternal Peripheral Blood: A Review

1996 ◽  
Vol 39 (4) ◽  
pp. 801-813 ◽  
Author(s):  
C. DANAE STEELE ◽  
RONALD J. WAPNER ◽  
J. BRUCE SMITH ◽  
MARK K. HAYNES ◽  
LAIRD G. JACKSON
Keyword(s):  
Prenatal Diagnosis ◽  
Peripheral Blood ◽  
Fetal Cells ◽  
Maternal Peripheral Blood

563: In vitro culture of trophoblasts isolated from maternal circulation: A potential non-invasive approach to prenatal diagnosis

2008 ◽  
Vol 199 (6) ◽  
pp. S164
Author(s):  
Isabelle Desitter ◽  
Patrick Rozenberg ◽  
Naoual Benali-Furet ◽  
Yvon Cayre ◽  
Bussieres Laurence
Keyword(s):  
Prenatal Diagnosis ◽  
In Vitro Culture ◽  
Maternal Circulation ◽  
Invasive Approach ◽  
Non Invasive

scholarly journals Isolation and Enrichment of Circulating Fetal Cells for NIPD: An Overview

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2239
Author(s):  
Giulia Sabbatinelli ◽  
Donatella Fantasia ◽  
Chiara Palka ◽  
Elisena Morizio ◽  
Melissa Alfonsi ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
High Efficiency ◽  
Diagnostic Testing ◽  
Genetic Research ◽  
Clinical Genetics ◽  
Maternal Circulation ◽  
Fetal Cells ◽  
Non Invasive ◽  
Prenatal Diagnostic ◽  
Maternal Peripheral Blood

Prenatal diagnosis plays a crucial role in clinical genetics. Non-invasive prenatal diagnosis using fetal cells circulating in maternal peripheral blood has become the goal of prenatal diagnosis, to obtain complete fetal genetic information and avoid risks to mother and fetus. The development of high-efficiency separation technologies is necessary to obtain the scarce fetal cells from the maternal circulation. Over the years, multiple approaches have been applied, including choice of the ideal cell targets, different cell recovering technologies, and refined cell isolation yield procedures. In order to provide a useful tool and to give insights about limitations and advantages of the technologies available today, we review the genetic research on the creation and validation of non-invasive prenatal diagnostic testing protocols based on the rare and labile circulating fetal cells during pregnancy.

scholarly journals Prenatal Diagnosis of Fetal Trisomy 21 from Maternal Peripheral Blood

2003 ◽  
Vol 44 (2) ◽  
pp. 181 ◽  
Author(s):  
Young Ho Yang ◽  
Sung Hoon Kim ◽  
Eun Suk Yang ◽  
Sei Kwang Kim ◽  
In Kyu Kim ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Peripheral Blood ◽  
Trisomy 21 ◽  
Maternal Peripheral Blood

scholarly journals Research Progress in Isolation and Enrichment of Fetal Cells from Maternal Blood

2022 ◽  
Vol 2022 ◽  
pp. 1-8
Author(s):  
Ying Tang ◽  
Qiaojin Tang ◽  
Haiyan Luo ◽  
Xuehui Zhang ◽  
Qiuyu Chen ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Peripheral Blood ◽  
Genetic Diseases ◽  
Genetic Material ◽  
High Sensitivity ◽  
Research Progress ◽  
Current Status ◽  
Fetal Cells ◽  
Noninvasive Prenatal Diagnosis ◽  
Maternal Peripheral Blood

Prenatal diagnosis is an important means of early diagnosis of genetic diseases, which can effectively reduce the risk of birth defects. Free fetal cells, as a carrier of intact fetal genetic material, provide hope for the development of high-sensitivity and high-accuracy prenatal diagnosis technology. However, the number of fetal cells is small and it is difficult to apply clinically. In recent years, noninvasive prenatal diagnosis (NIPD) technology for fetal genetic material in maternal peripheral blood has developed rapidly, which makes it possible to diagnose genetic diseases by fetal cells in maternal peripheral blood. This article reviewed the current status of fetal cell separation and enrichment technology and its application in noninvasive prenatal diagnosis technology.

Prenatal diagnosis on fetal cells obtained from maternal peripheral blood: Report of 66 cases

1999 ◽  
Vol 19 (10) ◽  
pp. 934-940 ◽  
Author(s):  
M. Rodríguez de Alba ◽  
P. Palomino ◽  
A. Jurado ◽  
R. Sanz ◽  
M. A. Ibañez ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Peripheral Blood ◽  
Fetal Cells ◽  
Maternal Peripheral Blood
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