Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndrome

2009 ◽  
Vol 29 (13) ◽  
pp. 1249-1255 ◽  
Author(s):  
Michael Christiansen

Endocrinology ◽  
1992 ◽  
Vol 130 (2) ◽  
pp. 1074-1076
Author(s):  
S D Cramer ◽  
R Barnard ◽  
C Engbers ◽  
G Thordarson ◽  
F Talamantes




Metabolism ◽  
1994 ◽  
Vol 43 (3) ◽  
pp. 357-359 ◽  
Author(s):  
Nelly Mauras ◽  
Lena M.S. Carlsson ◽  
Suzanne Murphy ◽  
Thomas J. Merimee




1993 ◽  
Vol 129 (6) ◽  
pp. 559-564 ◽  
Author(s):  
Guy Massa ◽  
Mapoko Ilondo ◽  
Magda Vanderschueren-Lodeweyckx

The characteristics of the human serum growth hormone-binding protein (GHBP) were compared with those of a water-soluble GH-binding site prepared by incubating cultured IM-9 lymphocytes in assay buffer with 25 mmol/l iodoacetamide. High-performance liquid chromatography gel filtration of the water-soluble GH-binding site incubated with 125I-labeled human GH ([125I]hGH) revealed a large peak of bound [125I]hGH eluting at the same position as the peak of [125I]hGH bound to the GHBP in serum. The estimated Mr of the peak was 120 000, presumably representing one [125I]hGH bound to two binding sites. The binding specificities of the serum GHBP, the water-soluble GH-binding site and the GH receptor on IM-9 lymphocytes were identical. The binding affinities for 22 000 hGH and for 20 000 hGH of the serum GHBP were similar to the binding affinity of the water-soluble GH-binding site but lower than those of the cellular GH receptor. These findings show that the characteristics of the serum GHBP are comparable to those of the water-soluble GH-binding site released from IM-9 cells and support the hypothesis that in man the serum GHBP is produced by proteolytic cleavage of the cellular GH receptor.



1991 ◽  
Vol 73 (1) ◽  
pp. 175-181 ◽  
Author(s):  
PAUL M. MARTHA ◽  
ALAN D. ROGOL ◽  
ROBERT M. BLIZZARD ◽  
MELISSA A. SHAW ◽  
GERHARD BAUMANN


1996 ◽  
Vol 44 (6) ◽  
pp. 673-678 ◽  
Author(s):  
J. Kratzsch ◽  
K. Kellner ◽  
T. Zilkens ◽  
H. Schmidt-Gayk ◽  
T. Selisko ◽  
...  




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