First trimester maternal serum placental growth factor in trisomy 21 pregnancies

2010 ◽  
Vol 30 (5) ◽  
pp. 449-453 ◽  
Author(s):  
N. J. Cowans ◽  
A. Stamatopoulou ◽  
K. Spencer
Keyword(s):  
Growth Factor ◽  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor

scholarly journals Early first-trimester maternal serum placental growth factor in trisomy 21 pregnancies

2011 ◽  
Vol 37 (5) ◽  
pp. 515-519 ◽  
Author(s):  
N. J. Cowans ◽  
A. Stamatopoulou ◽  
N. Tørring ◽  
K. Spencer
Keyword(s):  
Growth Factor ◽  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor

First-trimester maternal serum metastin, placental growth factor and chitotriosidase levels in pre-eclampsia

2012 ◽  
Vol 164 (2) ◽  
pp. 146-149 ◽  
Author(s):  
Riza Madazli ◽  
Berk Bulut ◽  
Abdullah Tuten ◽  
Burcu Aydin ◽  
Gökhan Demirayak ◽  
...  
Keyword(s):  
Growth Factor ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor

Maternal serum placental growth factor and α -fetoprotein testing in first trimester screening for Down syndrome

2013 ◽  
Vol 33 (5) ◽  
pp. 457-461 ◽  
Author(s):  
Kim Donalson ◽  
Steve Turner ◽  
Lesley Morrison ◽  
Päivi Liitti ◽  
Christel Nilsson ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Growth Factor ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor ◽  
First Trimester Screening ◽  
Trimester Screening

First trimester maternal serum placenta growth factor (PIGF)concentrations in pregnancies with fetal trisomy 21 or trisomy 18

2001 ◽  
Vol 21 (9) ◽  
pp. 718-722 ◽  
Author(s):  
Kevin Spencer ◽  
Adolfo W. Liao ◽  
Charas Y. T. Ong ◽  
Lut Geerts ◽  
Kypros H. Nicolaides
Keyword(s):  
Growth Factor ◽  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Serum ◽  
Trisomy 18 ◽  
Placenta Growth Factor

First trimester maternal serum placental growth factor levels in twin pregnancies

2013 ◽  
Vol 33 (13) ◽  
pp. 1260-1263 ◽  
Author(s):  
Nicholas J. Cowans ◽  
Kevin Spencer
Keyword(s):  
Growth Factor ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor ◽  
Twin Pregnancies

scholarly journals Impact of replacing or adding placental growth factor on Down syndrome screening: a prospective cohort study

2020 ◽  
Author(s):  
Wing To Angela Sin ◽  
Liona Poon ◽  
Piya Chaemsaithong ◽  
Yi Man Wah ◽  
Shuk Yi Annie Hui ◽  
...  
Keyword(s):  
Growth Factor ◽  
Test Performance ◽  
Trisomy 21 ◽  
Detection Rate ◽  
False Positive Rate ◽  
First Trimester ◽  
Placental Growth Factor ◽  
Singleton Pregnancy ◽  
Combined Test ◽  
Positive Rate

Objectives: To assess whether adding placental growth factor (PlGF) or replacing pregnancy-associated plasma protein-A (PAPP-A) improves the first trimester combined test performance for trisomy 21. Design: Prospective observation Cohort Setting: The Chinese University of Hong Kong, China Sample: 11,518 women having a singleton pregnancy screened for trisomy 21 between December 2016 and December 2019 using the first trimester combined test. Methods: PlGF was prospectively measured and estimated term risk for trisomy 21 was calculated by 1) replacing PAPP-A with PlGF and 2) adding PlGF to the combined test which includes nuchal translucency, PAPP-A and free β-human chorionic gonadotropin (hCG). Main Outcome Measure: Screening performance, area under curve (AUC), detection rate (DR), screen positive rate (SPR) and false positive rate (FPR) Results: 29 women had trisomy 21. The combined tests DR, FPR and SPR were 89.7%, 5.7% and 6% respectively. DR when replacing PAPP-A or adding PlGF to the combined test remained unchanged. Replacing PAPP-A by PlGF increased FPR and SPR to 6.2% and 6.4% respectively. Adding PlGF to the combined test gave FPR and SPR rates of 5.5% and 5.7% respectively. Adding or replacing PlGF did not give a significant increase in AUC (p>0.48) over that of the combined test. Conclusion: Adding PlGF to the combined test or replacing PAPP-A with PlGF in the combined test did not improve trisomy 21 detection rate. Replacing PAPP-A by PlGF increased SPR, whilst adding PlGF resulted in only a marginal reduction in SPR.

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