First trimester maternal serum placental growth factor levels in twin pregnancies

2013 ◽  
Vol 33 (13) ◽  
pp. 1260-1263 ◽  
Author(s):  
Nicholas J. Cowans ◽  
Kevin Spencer
Keyword(s):  
Growth Factor ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor ◽  
Twin Pregnancies

scholarly journals Maternal Serum Placental Growth Factor, Soluble Fms-Like Tyrosine Kinase-1, and Soluble Endoglin in Twin Gestations and the Risk of Preeclampsia—A Systematic Review

2020 ◽  
Vol 9 (1) ◽  
pp. 183 ◽  
Author(s):  
Katarzyna Kosinska-Kaczynska ◽  
Magdalena Zgliczynska ◽  
Szymon Kozlowski ◽  
Lukasz Wicherek
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Serum Levels ◽  
Maternal Serum ◽  
Placental Growth Factor ◽  
Cochrane Library ◽  
Original Research ◽  
Multiple Gestation ◽  
Soluble Endoglin ◽  
Twin Pregnancies

Multiple gestation is one of the key risk factors for the occurrence of preeclampsia (PE). Soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin are molecules involved in the process of angiogenesis with a proven role in the pathogenesis of PE. The aim of the review was to summarize available data on maternal serum levels of the above-mentioned factors and their usefulness in predicting PE in twin pregnancies. Only original research articles written in English were considered eligible. Reviews, chapters, case studies, conference papers, experts’ opinions, editorials, and letters were excluded from the analysis. No publication date limitations were imposed. The systematic literature search using PubMed/MEDLINE, Scopus, Embase, and Cochrane Library databases identified 338 articles, 10 of which were included in the final qualitative analyses. The included studies showed significant differences in maternal serum levels of the discussed factors between women with twin pregnancies with PE and those who did not develop PE, and their promising performance in predicting PE, alone or in combination with other factors. The identification of the most effective algorithms, their prompt introduction to the clinical practice, and further assessment of the real-life performance should become a priority.

First-trimester maternal serum metastin, placental growth factor and chitotriosidase levels in pre-eclampsia

2012 ◽  
Vol 164 (2) ◽  
pp. 146-149 ◽  
Author(s):  
Riza Madazli ◽  
Berk Bulut ◽  
Abdullah Tuten ◽  
Burcu Aydin ◽  
Gökhan Demirayak ◽  
...  
Keyword(s):  
Growth Factor ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor

Maternal serum placental growth factor and α -fetoprotein testing in first trimester screening for Down syndrome

2013 ◽  
Vol 33 (5) ◽  
pp. 457-461 ◽  
Author(s):  
Kim Donalson ◽  
Steve Turner ◽  
Lesley Morrison ◽  
Päivi Liitti ◽  
Christel Nilsson ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Growth Factor ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor ◽  
First Trimester Screening ◽  
Trimester Screening

scholarly journals Early first-trimester maternal serum placental growth factor in trisomy 21 pregnancies

2011 ◽  
Vol 37 (5) ◽  
pp. 515-519 ◽  
Author(s):  
N. J. Cowans ◽  
A. Stamatopoulou ◽  
N. Tørring ◽  
K. Spencer
Keyword(s):  
Growth Factor ◽  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor

First trimester maternal serum placental growth factor in trisomy 21 pregnancies

2010 ◽  
Vol 30 (5) ◽  
pp. 449-453 ◽  
Author(s):  
N. J. Cowans ◽  
A. Stamatopoulou ◽  
K. Spencer
Keyword(s):  
Growth Factor ◽  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Serum ◽  
Placental Growth Factor

scholarly journals Soluble fms-Like Tyrosine Kinase 1 Is Increased in Preeclampsia But Not in Normotensive Pregnancies with Small-for-Gestational-Age Neonates: Relationship to Circulating Placental Growth Factor

2005 ◽  
Vol 90 (8) ◽  
pp. 4895-4903 ◽  
Author(s):  
Eiji Shibata ◽  
Augustine Rajakumar ◽  
Robert W. Powers ◽  
Robert W. Larkin ◽  
Carol Gilmour ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Vascular Dysfunction ◽  
Normal Pregnancy ◽  
Maternal Serum ◽  
Placental Growth Factor ◽  
Gestational Age At Delivery ◽  
Placental Protein

Context: An excess of the soluble receptor, fms-like tyrosine kinase 1 (sFlt-1) may contribute to maternal vascular dysfunction in women with preeclampsia by binding and thereby reducing concentrations of free vascular endothelial growth factor and placental growth factor (PlGF) in the circulation. The putative stimulus for increased sFlt-1 during preeclampsia, placental hypoxia due to poor perfusion, is common to both preeclampsia and idiopathic intrauterine growth restriction. However, the latter condition occurs without maternal vascular disease. Objective: We asked whether, as with preeclampsia, sFlt-1 is increased and free PlGF is decreased in villous placenta and maternal serum of normotensive women with small-for-gestational-age (SGA) neonates. Study Design: This was a case-control study using banked samples. Groups of women with SGA neonates (birth weight centile < 10th) and women with preeclampsia were matched to separate sets of normal pregnancy controls based on gestational age at blood sampling (serum) or gestational age at delivery (placenta). Results: sFlt-1 levels were higher in preeclamptics than controls (serum, P < 0.0001; placental protein, P = 0.03; placental mRNA, P = 0.007) but not increased in SGA pregnancies. PlGF was lower in both preeclampsia (serum, P < 0.0001; placental protein, P = 0.05) and SGA (serum, P = 0.0008; placental protein, P = 0.03) compared with their controls. PlGF in preeclampsia and SGA groups did not differ. Conclusions: These data are consistent with a role for sFlt-1 in the maternal manifestations of preeclampsia. In contrast to preeclampsia, sFlt-1 does not appear to contribute substantially to decreased circulating free PlGF in SGA pregnancies in the absence of a maternal syndrome.

scholarly journals Prediction of small for gestational age neonates in twin pregnancies by first trimester maternal serum PAPP-A and free β-hCG

2014 ◽  
Vol 22 (3) ◽  
pp. 152-155
Author(s):  
Dilek Beker Şanlı ◽  
Kazım Kartkaya ◽  
Fezan Şahin Mutlu
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
First Trimester ◽  
Maternal Serum ◽  
Β Hcg ◽  
Twin Pregnancies
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