The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders

2018 ◽  
Vol 38 (3) ◽  
pp. 382-389 ◽  
Author(s):  
Denise K. Patten ◽  
Bob G. Schultz ◽  
Daniel J. Berlau
Keyword(s):  
Multiple Sclerosis ◽  
Chronic Pain ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Low Dose ◽  
Safety And Efficacy ◽  
Low Dose Naltrexone

scholarly journals Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Amine Benmassaoud ◽  
Xuanqian Xie ◽  
Motaz AlYafi ◽  
Yves Theoret ◽  
Alain Bitton ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Retrospective Study ◽  
Crohn's Disease ◽  
Adverse Events ◽  
Low Dose ◽  
Tpmt Activity ◽  
Safety And Efficacy ◽  
Full Dose ◽  
Index Treatment ◽  
Efficacy Profile

Background and Aims.Thiopurines are used in the treatment of Crohn’s disease (CD) and thiopurine S-methyltransferase (TPMT) activity can guide thiopurine dosing to avoid adverse events. This retrospective study evaluated the safety and efficacy of starting thiopurines at low dose versus full dose in patients with CD and normal TPMT.Methods.This was a single center retrospective study including adult CD patients with normal TPMT levels (≥25 nmol/hr/g Hgb) who were followed for 1 year. Patients started at full dose of azathioprine (2–2.5 mg/kg) or 6-mercaptopurine (1–1.5 mg/kg) were compared to patients started at low dose. Harvey-Bradshaw index, treatment failure, and drug-related adverse events were recorded.Results.Our study included 134 patients. Both groups had similar incidences of drug-related adverse events and discontinuation of therapy due to side effects. Fifty-six percent of all adverse events occurred within 31 days and 92% occurred within 3 months of therapy. Clinical response favored the full-dose group at 6 months (69% versus 27%,p=0.0542).Conclusions.Our study indicates that it is safe to start patients on full-dose thiopurine when they have a normal TPMT given its very similar toxicity profile to patients started on low dose. This may also positively impact efficacy.

Tu1365 Low Dose Naltrexone in the Treatment of Crohn's Disease: A Case Series

2015 ◽  
Vol 148 (4) ◽  
pp. S-870
Author(s):  
Sunina Nathoo ◽  
Sarah C. Glover
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Low Dose ◽  
Case Series ◽  
Low Dose Naltrexone

scholarly journals Low dose naltrexone for induction of remission in Crohn's disease

2018 ◽  
Author(s):  
Claire E Parker ◽  
Tran M Nguyen ◽  
Dan Segal ◽  
John K MacDonald ◽  
Nilesh Chande
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Low Dose ◽  
Low Dose Naltrexone

Low-Dose Naltrexone Therapy Improves Active Crohn's Disease

2007 ◽  
Vol 102 (4) ◽  
pp. 820-828 ◽  
Author(s):  
Jill P. Smith ◽  
Heather Stock ◽  
Sandra Bingaman ◽  
David Mauger ◽  
Moshe Rogosnitzky ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Low Dose ◽  
Low Dose Naltrexone

Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats

Neuropeptides ◽  
2016 ◽  
Vol 59 ◽  
pp. 39-45 ◽  
Author(s):  
Dina Ibrahim Tawfik ◽  
Afaf Sayed Osman ◽  
Hedayat Mahmoud Tolba ◽  
Aida Khattab ◽  
Lubna O. Abdel-Salam ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Therapeutic Effect ◽  
Low Dose ◽  
Low Dose Naltrexone ◽  
Experimentally Induced

Low dose naltrexone for induction of remission in Crohn's disease

2013 ◽  
Author(s):  
Dan Segal ◽  
John K MacDonald ◽  
Nilesh Chande
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Low Dose ◽  
Low Dose Naltrexone

scholarly journals Safety and Tolerability of Low-dose Naltrexone Therapy in Children With Moderate to Severe Crohn’s Disease

2013 ◽  
Vol 47 (4) ◽  
pp. 339-345 ◽  
Author(s):  
Jill P. Smith ◽  
Douglas Field ◽  
Sandra I. Bingaman ◽  
Robert Evans ◽  
David T. Mauger
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Low Dose ◽  
Low Dose Naltrexone
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