Hydrophobic modified poly(L‐glutamic acid) graft copolymer micelles with ultrahigh drug loading capacity for anticancer drug delivery

2021 ◽  
Author(s):  
Si Dong ◽  
Yue Tang ◽  
Pan He ◽  
Sheng Ma ◽  
Wantong Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glutamic Acid ◽  
Anticancer Drug ◽  
Graft Copolymer ◽  
Drug Loading ◽  
Loading Capacity ◽  
Anticancer Drug Delivery ◽  
Copolymer Micelles

Simultaneously Photo-Cleavable and Activatable Prodrug-Backboned Block Copolymer Micelles for Precise Anticancer Drug Delivery

2016 ◽  
Vol 5 (19) ◽  
pp. 2493-2499 ◽  
Author(s):  
Dongfang Zhou ◽  
Jinshan Guo ◽  
Gloria B. Kim ◽  
Jizhen Li ◽  
Xuesi Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Loading ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Micellar Aggregates ◽  
Reversible Addition ◽  
Hydrogen Carbonate ◽  
Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

Biamphiphilic triblock copolymer micelles as a multifunctional platform for anticancer drug delivery

2010 ◽  
Vol 96A (2) ◽  
pp. 330-340 ◽  
Author(s):  
Wen Zhu ◽  
YanLi Li ◽  
LiXin Liu ◽  
WenLong Zhang ◽  
YongMing Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Triblock Copolymer ◽  
Anticancer Drug Delivery ◽  
Copolymer Micelles ◽  
Multifunctional Platform

Superparamagnetic yolk–shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 103399-103411 ◽  
Author(s):  
Tuan-Wei Sun ◽  
Ying-Jie Zhu ◽  
Feng Chen ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
High Performance ◽  
Drug Loading ◽  
Magnesium Silicate ◽  
Loading Capacity ◽  
Ph Responsive ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
High Drug Loading

The as-prepared yolk–shell porous nanospheres of SPIO@MS exhibit a high drug loading capacity, and a sustained and pH-responsive drug release behaviour.

Hydrogen Sulfide-Activatable Prodrug-Backboned Block Copolymer Micelles for Delivery of Chemotherapeutics

2021 ◽  
Author(s):  
Jiajia Xiang ◽  
Peiwen Xing ◽  
Liu Xin ◽  
Peihong Shen ◽  
Shiqun Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Block Copolymer ◽  
Anticancer Drug ◽  
Amphiphilic Block Copolymer ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Block Copolymer Micelles ◽  
Stable Core ◽  
Copolymer Micelles

Amphiphilic block copolymer prodrugs, which can self-assemble into stable core-shell micelles, have been widely used for anticancer drug delivery. However, a major challenge remains to design drug-conjugating linkers stable in...

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