Perspective: Do macromolecules play a role in the mechanisms of nerve stimulation and nervous transmission?

2015 ◽  
Vol 54 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Gary E. Wnek

1984 ◽  
Vol 113 (1) ◽  
pp. 253-267 ◽  
Author(s):  
J. D. METCALFE ◽  
P. J. BUTLER

The motor innervation of the gill blood vessels of the dogfish Scyliorhinus canicula L. has been investigated by electrical stimulation of (1) the branchial branches of the IXth and Xth cranial nerves in isolated perfused 1st holobranch preparations and (2) both Xth cranial nerves in whole anaesthetized fish. The observed vascular responses to nerve stimulation appear to be entirely due to contraction of the striated muscles of the gill arch and not to any direct motor innervation of the major gill blood vessels since the responses were blocked only by the drug pancuronium, which blocks striated muscle motor end-plates. The specificity of pancuronium for the motor end-plate of striated muscle in the dogfish was established by showing that it did not block nervous transmission across the cardiac ganglia. The results from the nerve stimulation studies have been investigated further by pharmacological studies on isolated perfused gill preparations. Acetylcholine produces an atropine-sensitive increase in resistance to perfusion, while both adrenalin and noradrenalin decrease the resistance to perfusion.



2019 ◽  
Vol 28 (4) ◽  
pp. 1381-1387
Author(s):  
Ying Yuan ◽  
Jie Wang ◽  
Dongyu Wu ◽  
Dahua Zhang ◽  
Weiqun Song

Purpose Severe dysphagia with weak pharyngeal peristalsis after dorsal lateral medullary infarction (LMI) requires long-term tube feeding. However, no study is currently available on therapeutic effectiveness in severe dysphagia caused by nuclear damage of vagus nerve after dorsal LMI. The purpose of the present investigation was to explore the potential of transcutaneous vagus nerve stimulation (tVNS) to improve severe dysphagia with weak pharyngeal peristalsis after dorsal LMI. Method We assessed the efficacy of 6-week tVNS in a 28-year-old woman presented with persisting severe dysphagia after dorsal LMI who had been on nasogastric feeding for 6 months. tVNS was applied for 20 min twice a day, 5 days a week, for 6 weeks. The outcome measures included saliva spitted, Swallow Function Scoring System, Functional Oral Intake Scale, Clinical Assessment of Dysphagia With Wallenberg Syndrome, Yale Pharyngeal Residue Severity Rating Scale, and upper esophagus X-ray examination. Results After tVNS, the patient was advanced to a full oral diet without head rotation or spitting. No saliva residue was found in the valleculae and pyriform sinuses. Contrast medium freely passed through the upper esophageal sphincter. Conclusion Our findings suggest that tVNS might provide a useful means for recovery of severe dysphagia with weak pharyngeal peristalsis after dorsal LMI. Supplemental Material https://doi.org/10.23641/asha.9755438



2004 ◽  
Vol 171 (4S) ◽  
pp. 328-328 ◽  
Author(s):  
Anco van Voskuilen ◽  
Philip E.V. van Kerrebroeck ◽  
Hero Dijkema ◽  
Bart Bemelmans ◽  
A. Lycklama A. Nijholt ◽  
...  


2005 ◽  
Vol 38 (16) ◽  
pp. 39
Author(s):  
HEIDI SPLETE


2021 ◽  
Vol 3 (1) ◽  
pp. e14-e15
Author(s):  
Mark C Genovese ◽  
Yaakov A Levine ◽  
David Chernoff


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