Antimicrobial susceptibility ofHaemophilus influenzae strains and antibiotics usage patterns in pediatric outpatients: Results from a children's hospital in China (2000–2004)

2008 ◽  
Vol 43 (5) ◽  
pp. 457-462 ◽  
Author(s):  
Aihua Wang ◽  
Sangjie Yu ◽  
Kaihu Yao ◽  
Wenshuang Zhang ◽  
Lin Yuan ◽  
...  

2014 ◽  
Vol 1 (suppl_1) ◽  
pp. S284-S284
Author(s):  
Jonathon Mcneil ◽  
Eric Kok ◽  
Kristina Hulten ◽  
Edward O. Mason ◽  
Sheldon L. Kaplan


1977 ◽  
Vol 9 (3) ◽  
pp. 207-210 ◽  
Author(s):  
Hajime Yoshioka ◽  
Paul Rudoy ◽  
Harris D. Riley ◽  
Keiko Yoshida


BMJ Open ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. e019611 ◽  
Author(s):  
Nguyen Duc Toan ◽  
Thomas C Darton ◽  
Christine J Boinett ◽  
James I Campbell ◽  
Abhilasha Karkey ◽  
...  

IntroductionThe clinical syndrome of neonatal sepsis, comprising signs of infection, septic shock and organ dysfunction in infants ≤4 weeks of age, is a frequent sequel to bloodstream infection and mandates urgent antimicrobial therapy. Bacterial characterisation and antimicrobial susceptibility testing is vital for ensuring appropriate therapy, as high rates of antimicrobial resistance (AMR), especially in low-income and middle-income countries, may adversely affect outcome. Ho Chi Minh City (HCMC) in Vietnam is a rapidly expanding city in Southeast Asia with a current population of almost 8 million. There are limited contemporary data on the causes of neonatal sepsis in Vietnam, and we hypothesise that the emergence of multidrug resistant bacteria is an increasing problem for the appropriate management of sepsis cases. In this study, we aim to investigate the major causes of neonatal sepsis and assess disease outcomes by clinical features, antimicrobial susceptibility profiles and genome composition.Method and analysisWe will conduct a prospective observational study to characterise the clinical and microbiological features of neonatal sepsis in a major children’s hospital in HCMC. All bacteria isolated from blood subjected to whole genome sequencing. We will compare clinical variables and outcomes between different bacterial species, genome composition and AMR gene content. AMR gene content will be assessed and stratified by species, years and contributing hospital departments. Genome sequences will be analysed to investigate phylogenetic relationships.Ethics and disseminationThe study will be conducted in accordance with the principles of the Declaration of Helsinki and the International Council on Harmonization Guidelines for Good Clinical Practice. Ethics approval has been provided by the Oxford Tropical Research Ethics Committee 35-16 and Vietnam Children’s Hospital 1 Ethics Committee 73/GCN/BVND1. The findings will be disseminated at international conferences and peer-reviewed journals.Trial registration numberISRCTN69124914; Pre-results.



2008 ◽  
Vol 18 (2) ◽  
pp. 76-86 ◽  
Author(s):  
Lauren Hofmann ◽  
Joseph Bolton ◽  
Susan Ferry

Abstract At The Children's Hospital of Philadelphia (CHOP) we treat many children requiring tracheostomy tube placement. With potential for a tracheostomy tube to be in place for an extended period of time, these children may be at risk for long-term disruption to normal speech development. As such, speaking valves that restore more normal phonation are often key tools in the effort to restore speech and promote more typical language development in this population. However, successful use of speaking valves is frequently more challenging with infant and pediatric patients than with adult patients. The purpose of this article is to review background information related to speaking valves, the indications for one-way valve use, criteria for candidacy, and the benefits of using speaking valves in the pediatric population. This review will emphasize the importance of interdisciplinary collaboration from the perspectives of speech-language pathology and respiratory therapy. Along with the background information, we will present current practices and a case study to illustrate a safe and systematic approach to speaking valve implementation based upon our experiences.







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