Structure‐activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase

2021 ◽  
Author(s):  
Jothi Anantharajan ◽  
Nithya Baburajendran ◽  
Grace Lin ◽  
Yong Yao Loh ◽  
Weijun Xu ◽  
...  
Keyword(s):  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Allosteric Inhibitors ◽  
Structure Activity

Discovery and Structure−Activity Relationship of Oxalylarylaminobenzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B

2003 ◽  
Vol 46 (11) ◽  
pp. 2093-2103 ◽  
Author(s):  
Gang Liu ◽  
Bruce G. Szczepankiewicz ◽  
Zhonghua Pei ◽  
David A. Janowick ◽  
Zhili Xin ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

2009 ◽  
Vol 19 (19) ◽  
pp. 5773-5777 ◽  
Author(s):  
Shyama Sidique ◽  
Sergey A. Shiryaev ◽  
Boris I. Ratnikov ◽  
Ananda Herath ◽  
Ying Su ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Hydrolytic Stability ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pyrazole Derivatives ◽  
Allosteric Inhibitors ◽  
West Nile ◽  
Structure Activity

scholarly journals Quantative STRUCTURE Activity Relationship (QSAR) Study of a Series of Molecules Derived from 2,3-dihydro-1H- perimidine having Activity against Protein Tyrosine Phosphatase 1B

2021 ◽  
pp. 23-34
Author(s):  
Tuo Nanou Tiéba ◽  
Dembele Georges Stephane ◽  
Soro Doh ◽  
Konate Bibata ◽  
Kodjo Charles Guillaume ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
External Validation ◽  
Structure Activity Relationship ◽  
Quantitative Model ◽  
Activity Relationship ◽  
Protein Tyrosine Phosphatase 1B ◽  
Qsar Study ◽  
Protein Tyrosine ◽  
Structure Activity

In order to study the Quantitative Structure Activity Relationship (QSAR) against protein tyrosine phosphatase 1B and descriptors, we used a series of fourteen (14) molecules derived from perimidine. The compounds were optimized at the computational level B3LYP / 6-31 G (d, p), to obtain the descriptors of the model. This study was performed using the Linear Multiple Regression (MLR) method. This tool allowed us to obtain a quantitative model from the descriptors that are, the overall softness (S), the energy of the lowest vacant (ELUMO), the bond length l (N-C1). This model has good statistical performance (R2 = 0.958; RMCE = 0.110; F = 43.870). In addition, the external validation test of Tropsha and the domain of applicability from the levers were verified.

α-Bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure–Activity relationship

2002 ◽  
Vol 12 (21) ◽  
pp. 3047-3050 ◽  
Author(s):  
Gulnur Arabaci ◽  
Tian Yi ◽  
Hua Fu ◽  
Mary E. Porter ◽  
Kirk D. Beebe ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Phosphatase Inhibitors ◽  
Protein Tyrosine ◽  
Structure Activity

Inhibition of protein tyrosine phosphatase 1B by flavonoids: A structure - activity relationship study

2018 ◽  
Vol 111 ◽  
pp. 474-481 ◽  
Author(s):  
Carina Proença ◽  
Marisa Freitas ◽  
Daniela Ribeiro ◽  
Joana L.C. Sousa ◽  
Félix Carvalho ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Structure Activity ◽  
Relationship Study

Structure–Activity Relationship and Rational Design of 3,4-Dephostatin Derivatives as Protein Tyrosine Phosphatase Inhibitors

Tetrahedron ◽  
2000 ◽  
Vol 56 (5) ◽  
pp. 741-752 ◽  
Author(s):  
Takumi Watanabe ◽  
Takayuki Suzuki ◽  
Yoji Umezawa ◽  
Tomio Takeuchi ◽  
Masami Otsuka ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Rational Design ◽  
Tyrosine Phosphatase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Phosphatase Inhibitors ◽  
Protein Tyrosine ◽  
Structure Activity

Structure–activity relationship studies of 3-substituted pyrazoles as novel allosteric inhibitors of MALT1 protease

2021 ◽  
Vol 41 ◽  
pp. 127996
Author(s):  
Ken Nunettsu Asaba ◽  
Yohei Adachi ◽  
Kazuyuki Tokumaru ◽  
Akira Watanabe ◽  
Yasufumi Goto ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Allosteric Inhibitors ◽  
Structure Activity ◽  
Substituted Pyrazoles

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Structure-activity-relationship (SAR) for in vitro antileishmanial activity of maesabalide (PX-6518) analogue natural products

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
L Maes ◽  
K Kuypers ◽  
M Vermeersch ◽  
P Cos ◽  
L Pieters ◽  
...  
Keyword(s):  
Natural Products ◽  
Structure Activity Relationship ◽  
Antileishmanial Activity ◽  
Activity Relationship ◽  
Structure Activity
Sign in / Sign up

Export Citation Format

Share Document