A perspective on the role of quantitative structure-activity and structure-property relationships in herbicide discovery

2012 ◽  
Vol 68 (4) ◽  
pp. 513-518 ◽  
Author(s):  
Robert D Clark
Keyword(s):  
Quantitative Structure ◽  
Structure Property ◽  
Structure Property Relationships ◽  
Structure Activity

The role of the dominant descriptor in targeted quantitative structure property relationships

2007 ◽  
Vol 62 (22) ◽  
pp. 6222-6233 ◽  
Author(s):  
Mordechai Shacham ◽  
Olaf Kahrs ◽  
Georgi St. Cholakov ◽  
Roumiana P. Stateva ◽  
Wolfgang Marquardt ◽  
...  
Keyword(s):  
Quantitative Structure ◽  
Structure Property ◽  
Structure Property Relationships ◽  
Quantitative Structure Property Relationships

A Review on Camptothecin Analogs with Promising Cytotoxic Profile

2019 ◽  
Vol 18 (13) ◽  
pp. 1796-1814 ◽  
Author(s):  
Sk. Abdul Amin ◽  
Nilanjan Adhikari ◽  
Tarun Jha ◽  
Shovanlal Gayen
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Structure Property ◽  
Cytotoxic Potential ◽  
Structure Property Relationships ◽  
Structure Activity ◽  
Camptothecin Analogs ◽  
Pharmacokinetic Properties ◽  
Quantitative Structure Activity Relationships

Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline type of alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic agent acting against a variety of cancer cell lines. Though searches have been continued for last six decades, still it is a demanding task to design potent and cytotoxic CPTs. Different CPT analogs are synthesized to enhance the cytotoxic potential as well as to increase the pharmacokinetic properties of these analogs. Some of these analogs were proven to be clinically effective in different cancer cell lines. In this article, different CPT analogs have been highlighted extensively to get a detail insight about the structure-property relationships as well as different quantitative structure-activity relationships (QSARs) modeling of these analogs are also discussed. This study may be beneficial for designing newer CPT analogs in future.

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