Synergistic effects of potassium channel blockers and pyrethroids: mosquitocidal activity and neuronal mode of action †

2020 ◽  
Author(s):  
Shiyao Jiang ◽  
Jeffrey R. Bloomquist
Keyword(s):  
Potassium Channel ◽  
Mode Of Action ◽  
Synergistic Effects ◽  
Channel Blockers ◽  
Mosquitocidal Activity ◽  
Potassium Channel Blockers

Proteinase inhibitor homologues as potassium channel blockers

1994 ◽  
Vol 1 (4) ◽  
pp. 246-250 ◽  
Author(s):  
Jean-Marc Lancelin ◽  
Marie-Françoise Foray ◽  
Marc Poncin ◽  
Michelle Hollecker ◽  
Dominique Marion
Keyword(s):  
Potassium Channel ◽  
Proteinase Inhibitor ◽  
Channel Blockers ◽  
Potassium Channel Blockers

scholarly journals Action Potentials in Rhodnius Oocytes: Repolarization is Sensitive to Potassium Channel Blockers

1986 ◽  
Vol 126 (1) ◽  
pp. 119-132
Author(s):  
M. J. O'DONNELL
Keyword(s):  
Potassium Channel ◽  
Action Potentials ◽  
Potassium Conductance ◽  
Channel Blockers ◽  
Calcium Dependent ◽  
Outward Rectification ◽  
Current Voltage ◽  
Potassium Channel Blockers ◽  
Potassium Conductances ◽  
Voltage Dependent

Depolarization of Rhodnius oocytes evokes action potentials (APs) whose rising phase is calcium-dependent. The ionic basis for the repolarizing (i.e. falling) phase of the AP was examined. Addition of potassium channel blockers (tetraethylammonium, tetrabutylammonium, 4-aminopyridine, atropine) to the bathing saline increased the duration and overshoot of APs. Intracellular injection of tetraethyl ammonium had similar effects. These results suggest that a voltage-dependent potassium conductance normally contributes to repolarization. Repolarization does not require a chloride influx, because substitution of impermeant anions for chloride did not increase AP duration. AP duration and overshoot actually decreased progressively when chloride levels were reduced. Current/voltage curves show inward and outward rectification, properties often associated with potassium conductances. Outward rectification was largely blocked by external tetraethylammonium. Possible functions of the rectifying properties of the oocyte membrane are discussed.

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