Hepatoprotective Effects of a Proprietary Glycyrrhizin Product during Alcohol Consumption: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

2016 ◽  
Vol 30 (12) ◽  
pp. 1943-1953 ◽  
Author(s):  
Harsha Chigurupati ◽  
Biswajit Auddy ◽  
M. Biyani ◽  
Sidney J. Stohs
Keyword(s):  
Alcohol Consumption ◽  
Crossover Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Hepatoprotective Effects

Effect of Stevia on Glycemic and Insulin Responses in Obese Patients—A Randomized, Double-Blind, Placebo-Controlled Crossover Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 790-P
Author(s):  
PARINYA SAMAKKARNTHAI ◽  
MANAPORN PAYANUNDANA ◽  
NATTAPOL SATHAVARODOM ◽  
CHONPITI SIRIWAN ◽  
APUSSANEE BOONYAVARAKUL
Keyword(s):  
Crossover Study ◽  
Obese Patients ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Insulin Responses

scholarly journals Acute and Short-term Chronic Testosterone Fluctuation Effects on Glucose Homeostasis, Insulin Sensitivity, and Adiponectin: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

2014 ◽  
Vol 99 (6) ◽  
pp. E1088-E1096 ◽  
Author(s):  
Christian Høst ◽  
Lars C. Gormsen ◽  
David M. Hougaard ◽  
Jens S. Christiansen ◽  
Steen B. Pedersen ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Glucose Metabolism ◽  
Crossover Study ◽  
High Molecular Weight ◽  
Glucose Disposal ◽  
Short Term ◽  
High Molecular Weight Adiponectin ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Glucose

Context: Low levels of adiponectin and T in men have been shown to predict development of the metabolic syndrome, but the effects of T on glucose metabolism are incompletely understood and may be influenced either directly or indirectly through changes in body composition or in levels of adiponectin. Objective: The aim of the study was to test whether T exerts its effects on glucose metabolism directly or indirectly. Design, Setting, and Participants: In a randomized, double-blind, placebo-controlled, crossover study, 12 healthy young males were studied on four separate occasions. They received GnRH agonist treatment 1 month before 3 of 4 trial days to induce castrate levels of T. On trial days, T gel containing either high or low physiological T dose or placebo was applied to the body. On a fourth trial day, participants constituted their own eugonadal controls. Intervention: Each study comprised a 5-hour basal period and a 3-hour hyperinsulinemic euglycemic clamp. Main Outcome Measures: We measured the effect of acute T on peripheral glucose disposal, total adiponectin and subforms, and other indices of glucose metabolism. Results: Short-term hypogonadism was associated with increased high molecular weight adiponectin levels (P < .03) and increased oxidative glucose disposal (P = .03) but not total glucose disposal (P = .07). Acute T treatment was an independent suppressor of high molecular weight adiponectin levels (P = .04) but did not affect total glucose disposal (P = .17). Conclusions: These data show that T can act through putative fast nongenomic pathways to affect adiponectin levels in humans. The early hypogonadal state is characterized by a marked shift in fuel oxidation from lipids toward glucose, which may rely partly on buffering capabilities of adiponectin.

The Development of Subsensitivity to Atropine Methylnitrate: A Double-blind, Placebo-controlled Crossover Study

1988 ◽  
Vol 138 (4) ◽  
pp. 771-774 ◽  
Author(s):  
Thurman R. Vaughan ◽  
Robert E. Bowen ◽  
David L. Goodman ◽  
Richard W. Weber ◽  
Harold S. Nelson
Keyword(s):  
Crossover Study ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Double-blind, placebo controlled, crossover study of lamotrigine in treatment resistant partial seizures.

1993 ◽  
Vol 56 (5) ◽  
pp. 448-453 ◽  
Author(s):  
G J Schapel ◽  
R G Beran ◽  
F J Vajda ◽  
S F Berkovic ◽  
M L Mashford ◽  
...  
Keyword(s):  
Crossover Study ◽  
Partial Seizures ◽  
Treatment Resistant ◽  
Double Blind ◽  
Double Blind Placebo
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