The anxiolytic effect of Sho-ju-sen, a Japanese herbal medicine, assessed by an elevated ­plus-maze test in mice

2001 ◽  
Vol 15 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Hisashi Kuribara ◽  
Hisato Iwata ◽  
Hideo Tomioka ◽  
Reiko Takahashi ◽  
Kazumi Goto ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Japanese Herbal Medicine

Vigabatrin has an anxiolytic effect in the elevated plus-maze test of anxiety

1992 ◽  
Vol 43 (2) ◽  
pp. 529-535 ◽  
Author(s):  
Ümit Sayin ◽  
Nuhan Purali ◽  
Tuncer Özkan ◽  
Tuncay Altug ◽  
Sevim Büyükdevrim
Keyword(s):  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

Role of Ventral Hippocampal GABAA and NMDA Receptors in the Anxiolytic Effect of Carbamazepine in Rats Using the Elevated Plus Maze Test

Pharmacology ◽  
2009 ◽  
Vol 84 (6) ◽  
pp. 356-366 ◽  
Author(s):  
Mehrnaz Rezvanfard ◽  
Mohammad-Reza Zarrindast ◽  
Payvand Bina
Keyword(s):  
Nmda Receptors ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

scholarly journals First Evidence for an Anxiolytic Effect of a Diterpenoid from Salvia Cinnabarina

2009 ◽  
Vol 4 (4) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Francesco Maione ◽  
Maria Camela Bonito ◽  
Mariantonella Colucci ◽  
Virginia Cozzolino ◽  
Angela Bisio ◽  
...  
Keyword(s):  
Motor Activity ◽  
Forced Swimming Test ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Spontaneous Motor Activity ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Sedative Activity ◽  
Swimming Test

The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMP1 on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMP1, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina.

scholarly journals Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

10.3791/58396 ◽  
2019 ◽  
Author(s):  
Csilla Ari ◽  
Dominic P. D’Agostino ◽  
David M. Diamond ◽  
Mark Kindy ◽  
Collin Park ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Video Tracking ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems

2020 ◽  
Vol 14 (1) ◽  
pp. 36-51 ◽  
Author(s):  
George L. da Silva Oliveira ◽  
José C. Correia L. da Silva ◽  
Ana P. dos Santos C. L da Silva ◽  
Chistiane M. Feitosa ◽  
Fernanda R. de Castro Almeida
Keyword(s):  
Receptor Antagonist ◽  
Molecular Mechanisms ◽  
Elevated Plus Maze ◽  
Feeding Test ◽  
Swiss Mice ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Gabaergic Receptors ◽  
Pre Treatment

Background: Central nervous system disorders such as anxiety, depression and epilepsy are characterized by sharing several molecular mechanisms in common and the involvement of the L-arginine/NO pathway in neurobehavioral studies with β-caryophyllene is still little discussed. Objectives: One of the objectives of the present study was to demonstrate the anxiolytic behavioral effect of β-caryophyllene (β-CBP) in female Swiss mice, as well as to investigate the molecular mechanisms underlying the results obtained. Methods: This study evaluated the neurobehavioral effects of β-CBP using the open field test, rota-rod test, elevated plus maze test, novelty suppressed feeding test, tail suspension test and forced swim test, as well as pilocarpine, pentylenetetrazole and isoniazid-induced epileptic seizure models. Results:: The results demonstrated that the neuropharmacological activities of β-CBP may involve benzodiazepine/GABAergic receptors, since the pre-treatment of β-CBP (200 mg/kg) associated with flumazenil (5 mg/kg, benzodiazepine receptor antagonist) and bicuculline (1 mg/kg, selective GABAA receptor antagonist) reestablished the anxiety parameters in the elevated plus-maze test, as well as the results of reduced latency to consume food in the novelty suppressed feeding test. In addition to benzodiazepine/GABAergic receptors, the neuropharmacological properties of β-CBP may be related to inhibition of nitric oxide synthesis, since pre-treatment with L-arginine (500- 750 mg/kg) reversed significantly the anxiolytic, antidepressant and anticonvulsant activities of β-CBP. Conclusion: The results obtained provide additional support in understanding the neuromolecular mechanisms underlying the anxiolytic, antidepressant and anticonvulsive properties of β-CBP in female Swiss mice.

scholarly journals Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventional interpretation of the test

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Hirotaka Shoji ◽  
Tsuyoshi Miyakawa
Keyword(s):  
Elevated Plus Maze ◽  
Plasma Corticosterone ◽  
Illumination Level ◽  
Test Battery ◽  
Lower Percentage ◽  
Behavioral Tests ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Corticosterone Response

AbstractThe elevated plus maze test is a widely used test for assessing anxiety-like behavior and screening novel therapeutic agents in rodents. Previous studies have shown that a variety of internal factors and procedural variables can influence elevated plus maze behavior. Although some studies have suggested a link between behavior and plasma corticosterone levels, the relationships between them remain unclear. In this study, we investigated the effects of experience with a battery of behavioral tests, the wall color of the closed arms, and illumination level on the behavior and plasma corticosterone responses in the elevated plus maze in male C57BL/6J mice. Mice were either subjected to a series of behavioral tests, including assessments of general health and neurological function, a light/dark transition test, and an open field test, or left undisturbed until the start of the elevated plus maze test. The mice with and without test battery experience were allowed to freely explore the elevated plus maze. The other two independent groups of naïve mice were tested in mazes with closed arms with different wall colors (clear, transparent blue, white, and black) or different illumination levels (5, 100, and 800 lx). Immediately after the test, blood was collected to measure plasma corticosterone concentrations. Mice with test battery experience showed a lower percentage of open arm time and entries and, somewhat paradoxically, had lower plasma corticosterone levels than the mice with no test battery experience. Mice tested in the maze with closed arms with clear walls exhibited higher open arm exploration than mice tested in the maze with closed arms with black walls, while there were no significant differences in plasma corticosterone levels between the different wall color conditions. Illumination levels had no significant effects on any measure. Our results indicate that experience with other behavioral tests and different physical features of the maze affect elevated plus maze behaviors. Increased open arm time and entries are conventionally interpreted as decreased anxiety-like behavior, while other possible interpretations are considered: open arm exploration may reflect heightened anxiety and panic-like reaction to a novel situation under certain conditions. With the possibility of different interpretations, the present findings highlight the need to carefully consider the test conditions in designing experiments and drawing conclusions from the behavioral outcomes in the elevated plus maze test in C57BL/6J mice.

scholarly journals Age-dependent effect of high cholesterol diets on anxiety-like behavior in elevated plus maze test in rats

2014 ◽  
Vol 10 (1) ◽  
pp. 30 ◽  
Author(s):  
Xu Hu ◽  
Tao Wang ◽  
Jia Luo ◽  
Shan Liang ◽  
Wei Li ◽  
...  
Keyword(s):  
Elevated Plus Maze ◽  
High Cholesterol ◽  
Dependent Effect ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Age Dependent
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