scholarly journals First Evidence for an Anxiolytic Effect of a Diterpenoid from Salvia Cinnabarina

2009 ◽  
Vol 4 (4) ◽  
pp. 1934578X0900400 ◽  
Author(s):  
Francesco Maione ◽  
Maria Camela Bonito ◽  
Mariantonella Colucci ◽  
Virginia Cozzolino ◽  
Angela Bisio ◽  
...  
Keyword(s):  
Motor Activity ◽  
Forced Swimming Test ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Spontaneous Motor Activity ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Sedative Activity ◽  
Swimming Test

The potential anxiolytic and anti-depressive activity of CMP1 was studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMP1 on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMP1, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina.

scholarly journals Electroacupuncture Promotes Proliferation of Amplifying Neural Progenitors and Preserves Quiescent Neural Progenitors from Apoptosis to Alleviate Depressive-Like and Anxiety-Like Behaviours

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Liu Yang ◽  
Na Yue ◽  
Xiaocang Zhu ◽  
Qiuqin Han ◽  
Bin Li ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Elevated Plus Maze ◽  
Neural Progenitors ◽  
Chronic Unpredictable Stress ◽  
Hippocampal Dentate Gyrus ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Swimming Test ◽  
Behavioural Tests

The present study was designed to investigate the effects of electroacupuncture (EA) on depressive-like and anxiety-like behaviours and neural progenitors in the hippocampal dentate gyrus (DG) in a chronic unpredictable stress (CUS) rat model of depression. After being exposed to a CUS procedure for 2 weeks, rats were subjected to EA treatment, which was performed on acupoints Du-20 (Bai-Hui) and GB-34 (Yang-Ling-Quan), once every other day for 15 consecutive days (including 8 treatments), with each treatment lasting for 30 min. The behavioural tests (i.e., forced swimming test, elevated plus-maze test, and open-field entries test) revealed that EA alleviated the depressive-like and anxiety-like behaviours of the stressed rats. Immunohistochemical results showed that proliferative cells (BrdU-positive) in the EA group were significantly larger in number compared with the Model group. Further, the results showed that EA significantly promoted the proliferation of amplifying neural progenitors (ANPs) and simultaneously inhibited the apoptosis of quiescent neural progenitors (QNPs). In a word, the mechanism underlying the antidepressant-like effects of EA is associated with enhancement of ANPs proliferation and preserving QNPs from apoptosis.

scholarly journals Investigation of the Pharmacological Properties of Lepidagathis hyalina Nees through Experimental Approaches

Life ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 180
Author(s):  
Fowzul Islam Fahad ◽  
Niloy Barua ◽  
Md. Shafiqul Islam ◽  
Syed Al Jawad Sayem ◽  
Koushik Barua ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Elevated Plus Maze ◽  
Tail Suspension Test ◽  
Clot Lysis ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Swimming Test ◽  
Dose Dependent

Lepidagathis hyalina Nees is used locally in Ayurvedic medicine to treat coughs and cardiovascular diseases. This study explored its pharmacological potential through in vivo and in vitro approaches for the metabolites extracted (methanolic) from the stems of L. hyalina. A qualitative phytochemical analysis revealed the presence of numerous secondary metabolites. The methanol extract of L. hyalina stems (MELHS) showed a strong antioxidative activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assays, and in the quantitative (phenolic and flavonoid) assay. Clot lysis and brine shrimp lethality bioassays were applied to investigate the thrombolytic and cytotoxic activities, respectively. MELHS exhibited an expressive percentage of clot lysis (33.98%) with a moderately toxic (115.11 μg/mL) effect. The in vivo anxiolytic activity was studied by an elevated plus maze test, whereas the antidepressant activity was examined by a tail suspension test and forced swimming test. During the anxiolytic evaluation, MELHS exhibited a significant dose-dependent reduction of anxiety, in which the 400 mg/kg dose of the extract showed 78.77 ± 4.42% time spent in the open arm in the elevated plus maze test. In addition, MELHS demonstrated dose-dependent and significant activities in the tail suspension test and forced swimming test, whereas the 400 mg/kg dose of the extract showed 87.67 ± 6.40% and 83.33 ± 6.39% inhibition of immobile time, respectively. Therefore, the current study suggests that L. hyalina could be a potential source of anti-oxidative, cytotoxic, thrombolytic, anxiolytic, and antidepressant agents. Further study is needed to determine the mechanism behind the bioactivities.

Vigabatrin has an anxiolytic effect in the elevated plus-maze test of anxiety

1992 ◽  
Vol 43 (2) ◽  
pp. 529-535 ◽  
Author(s):  
Ümit Sayin ◽  
Nuhan Purali ◽  
Tuncer Özkan ◽  
Tuncay Altug ◽  
Sevim Büyükdevrim
Keyword(s):  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze

The anxiolytic effect of Sho-ju-sen, a Japanese herbal medicine, assessed by an elevated ­plus-maze test in mice

2001 ◽  
Vol 15 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Hisashi Kuribara ◽  
Hisato Iwata ◽  
Hideo Tomioka ◽  
Reiko Takahashi ◽  
Kazumi Goto ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Elevated Plus Maze ◽  
Anxiolytic Effect ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Japanese Herbal Medicine

scholarly journals Evaluation of Neuropharmacological Activities of Methanolic Extract of Bacopa monnieri L. in Mice Model

2019 ◽  
pp. 41-49 ◽  
Keyword(s):  
Elevated Plus Maze ◽  
Test Group ◽  
Bacopa Monnieri ◽  
Control Group ◽  
Standard Group ◽  
Standard Drug ◽  
Elevated Plus Maze Test ◽  
Maze Test ◽  
Plus Maze ◽  
Swimming Test

Now-a-days, the use of natural products has increased its popularity day by day all over the world. One of the most effective therapeutic medicinal plants is Bacopa monnieri. In the current study, the methanolic distillate of B. monnieri was designed for an antidepressant in mice models. B. monnieri was evaluated for anti-depressant venture in the forced swimming test (FST), tail suspension test (TST) and elevated plus maze test. In force swimming test, imipramine (30 mg/kg) used as a standard drug and in TST as well as elevated plus maze test, diazepam (10 mg/kg) used as a standard and the plant extract (100 mg/kg and 200 mg/kg) was administered as test group and the control group was given deionized water. In this test, the test extracts (100 mg/kg and 200 mg/kg) compare to both control and standard group. The higher dose (200 mg/kg) represented a more significant effect than a dose of 100 mg/kg. In comparison to the standard and control, at dose 200 mg/kg represented a more significant effect at p<0.05 among three of the test.

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