scholarly journals Severe acute respiratory syndrome‐coronavirus‐2: Current advances in therapeutic targets and drug development

2020 ◽  
Author(s):  
Sakthivel Suganya ◽  
Suresh Divya ◽  
Madasamy Parani
Author(s):  
Eleanor Quek ◽  
Hasan Tahir ◽  
Poornima Kumar ◽  
Robert Hastings ◽  
Rajeev Jha

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread and have grave health and socioeconomic consequences worldwide. Researchers have raced to understand the pathophysiological mechanisms underpinning the disease caused by SARS-CoV-2 so that effective therapeutic targets can be discovered. This review summarises the key pharmacotherapies that are being investigated for treatment of COVID-19, including antiviral, immunomodulator and anticoagulation strategies.


2021 ◽  
Vol 26 ◽  
Author(s):  
Shadma Wahab ◽  
Irfan Ahmad ◽  
Safia Irfan ◽  
Mohammad Hassan Baig ◽  
Abd-ElAziem Farouk ◽  
...  

: The current 2019-nCoV outbreak is becoming extremely noxious and has affected the whole world. Its control is challenging because there is no effective vaccine or drug available for Coronavirus disease. The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), previously named as 2019 novel Coronavirus (2019-nCoV), primarily targets the human respiratory system to lung lesions and lethal pneumonia. Natural products have always shown a crucial role in the process of drug development against various diseases. They could be leads for further drug development to combat emergent mutants of the coronavirus. In this review, the current status of natural compounds and their derivatives acting against different species of CoV are discussed.


Author(s):  
Vanina A. ◽  
Diego J. Martinel Lamas ◽  
Pablo G. ◽  
Noelia Massari ◽  
Eliana Carabajal ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document