Design, Synthesis andin vitroAnticancer Activity of a Cu(II) Complex of Carminic Acid: A Novel Small Molecule Inhibitor of Human DNA Topoisomerase I and Topoisomerase II

2016 ◽  
Vol 1 (21) ◽  
pp. 6623-6631 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Susanta Roychoudhury ◽  
Hemanta Kumar Majumder ◽  
Saurabh Das
Keyword(s):  
Small Molecule ◽  
Topoisomerase I ◽  
Topoisomerase Ii ◽  
Carminic Acid ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Design Synthesis ◽  
Human Dna ◽  
Molecule Inhibitor ◽  
Human Dna Topoisomerase I

Monoclonal antibodies to human DNA topoisomerase I and the two isoforms of DNA topoisomerase II: 170- and 180-kDa isozymes

1992 ◽  
Vol 200 (2) ◽  
pp. 452-459 ◽  
Author(s):  
Claudia Negri ◽  
Roberto Chiesa ◽  
Antonella Cerino ◽  
Marco Bestagno ◽  
Cinzia Sala ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Topoisomerase I ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Isodiospyrin as a novel human DNA topoisomerase I inhibitor

2003 ◽  
Vol 66 (10) ◽  
pp. 1981-1991 ◽  
Author(s):  
Chun-Yuan Ting ◽  
Chia-Tse Hsu ◽  
Hsiang-Ting Hsu ◽  
Jin-Shan Su ◽  
Tzong-Yueh Chen ◽  
...  
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Topoisomerase I Inhibitor ◽  
Human Dna ◽  
Human Dna Topoisomerase I

Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59344-59357 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Sanjoy K. Dey ◽  
Rajat Saha ◽  
Abhishek Dutta Chowdhury ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Dna Interaction ◽  
Dna Topoisomerase I ◽  
Oxygen Species ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Anti Tumor Activity ◽  
Human Dna Topoisomerase I

Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic.

Rapid and prolonged stalling of human DNA topoisomerase I in UVA-irradiated genomic areas

DNA Repair ◽  
2007 ◽  
Vol 6 (12) ◽  
pp. 1757-1763 ◽  
Author(s):  
Christian Mielke ◽  
Faiza M. Kalfalah ◽  
Morten O. Christensen ◽  
Fritz Boege
Keyword(s):  
Topoisomerase I ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Human Dna Topoisomerase I
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