A photocatalytic system for the dearomative hydroarylation of benzene derivatives has been developed. Using a combination of an organic photoredox catalyst and an amine reductant, this process operates through a reductive radical-polar crossover mechanism where aryl halide reduction triggers a regioselective cyclization event, giving rise to a range of complex spirocyclic cyclohexadienes. This light-driven protocol functions at room temperature in a green solvent system (aq. MeCN), without the need for precious metal-based catalysts or reagents, or the generation of stoichiometric metal byproducts.
The insertion reaction of a broad range of diazo compounds into Si–H bonds was found to be efficiently catalysed by Fe(OTf)2 in an emerging green solvent i.e. dimethyl carbonate (DMC).
A concise one-pot three-component reaction of organic halides, terminal acetylenes, and sodium azide provided an efficient route for the synthesis of 1,2,3-triazoles. A variety of 1,2,3-triazoles were prepared in good to excellent yields with green solvent glycerol. This procedure used CuI and diethylamine, which are two easily available reagents as the new catalytic system at room temperature.
A versatile synthetic protocol involving the
room temperature direct arylation of benzothiazole with a wide variety of
iodo(hetero)arenes under palladium-catalyzed conditions and promoted by HFIP as
the reaction solvent has been presented herewith. An in-situ one-pot sequential
HFIP promoted selective iodination of (hetero)arenes followed by Pd-catalyzed
direct arylation of benzothiazole has also been disclosed. Synthesis of PMX 610 (antitumor agent) analog has been disclosed and also CJM 126 (antitumor agent) has been synthesized.
Iron(ii) triflate was used in combination with caffeine-derived salts as recyclable catalysts for the Diels–Alder reaction run in dimethyl carbonate (DMC) as a green solvent.
Investigation an environmentally friendly method under magnetic field as a green solvent for the synthesis of brookite phase nanoparticles at room temperature
