Tunable hydrogels for mesenchymal stem cell delivery: Integrin-induced transcriptome alterations and hydrogel optimization for human wound healing

Stem Cells ◽  
2019 ◽  
Author(s):  
Alina I. Marusina ◽  
Alexander A. Merleev ◽  
Jesus I. Luna ◽  
Laura Olney ◽  
Nathan E. Haigh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Delivery ◽  
Stem Cell Delivery

scholarly journals Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer

2009 ◽  
Vol 69 (10) ◽  
pp. 4134-4142 ◽  
Author(s):  
Michael R. Loebinger ◽  
Ayad Eddaoudi ◽  
Derek Davies ◽  
Sam M. Janes
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Metastatic Cancer ◽  
Cell Delivery ◽  
Stem Cell Delivery

Aggregate mesenchymal stem cell delivery ameliorates the regenerative niche for muscle repair

2018 ◽  
Vol 12 (8) ◽  
pp. 1867-1876 ◽  
Author(s):  
Marissa A. Ruehle ◽  
Hazel Y. Stevens ◽  
Aaron M. Beedle ◽  
Robert E. Guldberg ◽  
Jarrod A. Call
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Delivery ◽  
Muscle Repair ◽  
Stem Cell Delivery

Biomimetic chimeric peptide-tethered hydrogels for human mesenchymal stem cell delivery

2015 ◽  
Vol 136 ◽  
pp. 634-640 ◽  
Author(s):  
Gayong Shim ◽  
Gunwoo Kim ◽  
Junhyeok Choi ◽  
TacGhee Yi ◽  
Yun Kyoung Cho ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell ◽  
Cell Delivery ◽  
Stem Cell Delivery ◽  
Chimeric Peptide

scholarly journals Calcium phosphate combination biomaterials as human mesenchymal stem cell delivery vehicles for bone repair

2011 ◽  
Vol 97B (2) ◽  
pp. 235-244 ◽  
Author(s):  
Sang-Hyug Park ◽  
Aliassghar Tofighi ◽  
Xiaoqin Wang ◽  
Michael Strunk ◽  
Thomas Ricketts ◽  
...  
Keyword(s):  
Stem Cell ◽  
Calcium Phosphate ◽  
Mesenchymal Stem Cell ◽  
Bone Repair ◽  
Human Mesenchymal Stem Cell ◽  
Cell Delivery ◽  
Stem Cell Delivery ◽  
Delivery Vehicles

scholarly journals Multifunctional perfluorooctylbromide alginate microcapsules for monitoring of mesenchymal stem cell delivery using CT and MRI

2009 ◽  
Vol 11 (S1) ◽  
Author(s):  
Yingli Fu ◽  
Dorota Kedziorek ◽  
Ronald Ouwerkerk ◽  
Veronica Crisostomo ◽  
Wesley Gilson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Delivery ◽  
Stem Cell Delivery ◽  
Ct And Mri

scholarly journals A barrier against reactive oxygen species: chitosan/acellular dermal matrix scaffold enhances stem cell retention and improves cutaneous wound healing

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Wei Lin ◽  
Xiaoyang Qi ◽  
Wenjing Guo ◽  
Danyang Liang ◽  
Heting Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Delivery System ◽  
Acellular Dermal Matrix ◽  
Cell Delivery ◽  
Stem Cell Therapies ◽  
Dermal Matrix ◽  
Cell Therapies ◽  
Stem Cell Delivery ◽  
Acellular Dermal

Abstract Background Stem cell therapies have gained great attention for providing novel solutions for treatment of various injuries and diseases due to stem cells’ self-renewal, ability to differentiate into various cell types, and favorite paracrine function. Nevertheless, the low retention of transplanted stem cell still limits their clinical applications such as in wound healing in view of an induced harsh microenvironment rich in reactive oxygen species (ROS) during inflammatory reactions. Methods Herein, a novel chitosan/acellular dermal matrix (CHS/ADM) stem cell delivery system is developed, which is of great ROS scavenging activity and significantly attenuates inflammatory response. Result Under ROS microenvironment, this stem cell delivery system acts as a barrier, effectively scavenging an amount of ROS and protecting mesenchymal stem cells (MSCs) from the oxidative stress. It notably regulates intracellular ROS level in MSCs and reduces ROS-induced cellular death. Most importantly, such MSCs delivery system significantly enhances in vivo transplanted stem cell retention, promotes the vessel growth, and accelerates wound healing. Conclusions This novel delivery system, which overcomes the limitations of conventional plain collagen-based delivery system in lacking of ROS-environmental responsive mechanisms, demonstrates a great potential use in stem cell therapies in wound healing.

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