scholarly journals Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress

Stem Cells ◽  
2021 ◽  
Vol 39 (11) ◽  
pp. 1532-1545
Author(s):  
Joshua Tay ◽  
Valerie Barbier ◽  
Falak M. Helwani ◽  
Gareth R. Price ◽  
Jean‐Pierre Levesque ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Bone Marrow Niche ◽  
Cell Potential ◽  
Hematopoietic Stem ◽  
Stem Cell Potential

PROSTACYCLIN IS A NOVEL HEMATOPOIETIC STEM CELL REGULATOR ENRICHED IN THE ENDOSTEAL BONE MARROW NICHE

2019 ◽  
Vol 76 ◽  
pp. S88
Author(s):  
Joshua Tay ◽  
Jean-Pierre Levesque ◽  
Falak Helwani ◽  
Gareth Price ◽  
Valerie Barbier ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Bone Marrow Niche ◽  
Hematopoietic Stem

scholarly journals The Endoplasmic Reticulum Chaperone Protein GRP94 Is Required for Maintaining Hematopoietic Stem Cell Interactions with the Adult Bone Marrow Niche

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e20364 ◽  
Author(s):  
Biquan Luo ◽  
Ben S. Lam ◽  
Sung Hyung Lee ◽  
Shiuan Wey ◽  
Hui Zhou ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Endoplasmic Reticulum ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Bone Marrow Niche ◽  
Hematopoietic Stem ◽  
Adult Bone Marrow ◽  
Chaperone Protein ◽  
Endoplasmic Reticulum Chaperone ◽  
Adult Bone

Hematopoietic Stem Cell Aging: Wrinkles In Stem Cell Potential

2007 ◽  
Vol 3 (3) ◽  
pp. 201-211 ◽  
Author(s):  
S. M. Chambers ◽  
M. A. Goodell
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Aging ◽  
Cell Potential ◽  
Hematopoietic Stem ◽  
Stem Cell Aging ◽  
Stem Cell Potential

scholarly journals Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Longfei Gao ◽  
Matthew Decker ◽  
Haidee Chen ◽  
Lei Ding
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Critical Role ◽  
Bone Marrow Niche ◽  
Hematopoietic Stem ◽  
Hematopoietic Recovery ◽  
Cellular Source ◽  
Systemic Factors

The bone marrow niche plays a critical role in hematopoietic recovery and hematopoietic stem cell (HSC) regeneration after myeloablative stress. However, it is not clear whether systemic factors beyond the local niche are required for these essential processes in vivo. Thrombopoietin (THPO) is a critical cytokine promoting hematopoietic rebound after myeloablation and its transcripts are expressed by multiple cellular sources. The upregulation of bone marrow-derived THPO has been proposed to be crucial for hematopoietic recovery and HSC regeneration after stress. Nonetheless, the cellular source of THPO in myeloablative stress has never been investigated genetically. We assessed the functional sources of THPO following two common myeloablative perturbations: 5-fluorouracil (5-FU) administration and irradiation. Using a Thpo translational reporter, we found that the liver but not the bone marrow is the major source of THPO protein after myeloablation. Mice with conditional Thpo deletion from osteoblasts and/or bone marrow stromal cells showed normal recovery of HSCs and hematopoiesis after myeloablation. In contrast, mice with conditional Thpo deletion from hepatocytes showed significant defects in HSC regeneration and hematopoietic rebound after myeloablation. Thus, systemic THPO from the liver is necessary for HSC regeneration and hematopoietic recovery in myeloablative stress conditions.

scholarly journals Cellular players of hematopoietic stem cell mobilization in the bone marrow niche

2016 ◽  
Vol 105 (2) ◽  
pp. 129-140 ◽  
Author(s):  
Joshua Tay ◽  
Jean-Pierre Levesque ◽  
Ingrid G. Winkler
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Stem Cell Mobilization ◽  
Bone Marrow Niche ◽  
Hematopoietic Stem ◽  
Hematopoietic Stem Cell Mobilization ◽  
Cell Mobilization

scholarly journals Thrombopoietin from hepatocytes promotes hematopoietic stem cell regeneration after myeloablation

2021 ◽  
Author(s):  
Lei Ding ◽  
Longfei Gao ◽  
Matthew Decker ◽  
Haidee Chen
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Critical Role ◽  
Bone Marrow Niche ◽  
Hematopoietic Stem ◽  
Hematopoietic Recovery ◽  
Cellular Source ◽  
Systemic Factors

The bone marrow niche plays a critical role in hematopoietic recovery and hematopoietic stem cell (HSC) regeneration after myeloablation. However, it is not clear whether systemic factors beyond the local niche are required for these essential processes in vivo. Thrombopoietin (TPO) is a critical cytokine promoting hematopoietic rebound after myeloablation and its transcripts are expressed by multiple cellular sources. The upregulation of bone marrow-derived TPO has been proposed to be crucial for hematopoietic recovery and HSC regeneration after stress. Nonetheless, the cellular source of TPO in stress has never been investigated genetically. We assessed the functional sources of TPO following two common myeloablative perturbations: 5-fluorouracil (5-FU) administration and irradiation. Using a Tpo translational reporter, we found that the liver but not the bone marrow is the major source of TPO protein after myeloablation. Mice with conditional Tpo deletion from osteoblasts or bone marrow stromal cells showed normal recovery of HSCs and hematopoiesis after myeloablation. In contrast, mice with conditional Tpo deletion from hepatocytes showed significant defects in HSC regeneration and hematopoietic rebound after myeloablation. Thus, systemic TPO from the liver is necessary for HSC regeneration and hematopoietic recovery in myeloablative stress conditions.

Analyzing hematopoietic stem cell homing, lodgment, and engraftment to better understand the bone marrow niche

2014 ◽  
Vol 1310 (1) ◽  
pp. 119-128 ◽  
Author(s):  
Shen Y. Heazlewood ◽  
Ana Oteiza ◽  
Huimin Cao ◽  
Susan K. Nilsson
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Bone Marrow Niche ◽  
Hematopoietic Stem ◽  
Cell Homing ◽  
Stem Cell Homing

Hematopoietic stem cell stretches and moves in its bone marrow niche

2021 ◽  
pp. 103368
Author(s):  
Walison N. Silva ◽  
Alinne C. Costa ◽  
Caroline C. Picoli ◽  
Beatriz G.S. Rocha ◽  
Gabryella S.P. Santos ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Bone Marrow Niche ◽  
Hematopoietic Stem
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