scholarly journals Expression and Proliferation-Promoting Role of Diversin in the Neuronally Committed Precursor Cells Migrating in the Adult Mouse Brain

Stem Cells ◽  
2010 ◽  
Vol 28 (11) ◽  
pp. 2017-2026 ◽  
Author(s):  
Makiko Ikeda ◽  
Yuki Hirota ◽  
Masanori Sakaguchi ◽  
Osamu Yamada ◽  
Yasuyuki S. Kida ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Adult Mouse ◽  
Precursor Cells ◽  
Adult Mouse Brain

scholarly journals Embryonic Stem Cell-Derived Neuronally Committed Precursor Cells with Reduced Teratoma Formation After Transplantation into the Lesioned Adult Mouse Brain

Stem Cells ◽  
2006 ◽  
Vol 24 (6) ◽  
pp. 1458-1466 ◽  
Author(s):  
Marcel Dihné ◽  
Christian Bernreuther ◽  
Christian Hagel ◽  
Kai O. Wesche ◽  
Melitta Schachner
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Mouse Brain ◽  
Adult Mouse ◽  
Embryonic Stem ◽  
Precursor Cells ◽  
Adult Mouse Brain ◽  
Teratoma Formation

Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain

2019 ◽  
Vol 143 ◽  
pp. 31-43 ◽  
Author(s):  
Naoya Murao ◽  
Shuzo Matsubara ◽  
Taito Matsuda ◽  
Hirofumi Noguchi ◽  
Tetsuji Mutoh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Mouse Brain ◽  
Adult Mouse ◽  
Suppressor Gene ◽  
Precursor Cells ◽  
Adult Mouse Brain

EphA4 Regulates Hippocampal Neural Precursor Proliferation in the Adult Mouse Brain by d-Serine Modulation of N-Methyl-d-Aspartate Receptor Signaling

2018 ◽  
Vol 29 (10) ◽  
pp. 4381-4397 ◽  
Author(s):  
Jing Zhao ◽  
Chanel J Taylor ◽  
Estella A Newcombe ◽  
Mark D Spanevello ◽  
Imogen O’Keeffe ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Adult Mouse ◽  
Precursor Cells ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Neural Precursor ◽  
Adult Mouse Brain ◽  
Precursor Activity

Abstract The hippocampal dentate gyrus (DG) is a major region of the adult rodent brain in which neurogenesis occurs throughout life. The EphA4 receptor, which regulates neurogenesis and boundary formation in the developing brain, is also expressed in the adult DG, but whether it regulates adult hippocampal neurogenesis is not known. Here, we show that, in the adult mouse brain, EphA4 inhibits hippocampal precursor cell proliferation but does not affect precursor differentiation or survival. Genetic deletion or pharmacological inhibition of EphA4 significantly increased hippocampal precursor proliferation in vivo and in vitro, by blocking EphA4 forward signaling. EphA4 was expressed by mature hippocampal DG neurons but not neural precursor cells, and an EphA4 antagonist, EphA4-Fc, did not activate clonal cultures of precursors until they were co-cultured with non-precursor cells, indicating an indirect effect of EphA4 on the regulation of precursor activity. Supplementation with d-serine blocked the increased precursor proliferation induced by EphA4 inhibition, whereas blocking the interaction between d-serine and N-methyl-d-aspartate receptors (NMDARs) promoted precursor activity, even at the clonal level. Collectively, these findings demonstrate that EphA4 indirectly regulates adult hippocampal precursor proliferation and thus plays a role in neurogenesis via d-serine-regulated NMDAR signaling.

Haloperidol activates quiescent oligodendroglia precursor cells in the adult mouse brain

2010 ◽  
Vol 119 (1-3) ◽  
pp. 164-174 ◽  
Author(s):  
Hanzhi Wang ◽  
Haiyun Xu ◽  
Jianqin Niu ◽  
Feng Mei ◽  
Xinmin Li ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Adult Mouse ◽  
Precursor Cells ◽  
Adult Mouse Brain
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