scholarly journals THC alters alters morphology of neurons in medial prefrontal cortex, orbital prefrontal cortex, and nucleus accumbens and alters the ability of later experience to promote structural plasticity

Synapse ◽  
2017 ◽  
Vol 72 (3) ◽  
pp. e22020 ◽  
Author(s):  
Bryan Kolb ◽  
Yilin Li ◽  
Terry Robinson ◽  
Linda A. Parker
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Medial Prefrontal Cortex ◽  
Structural Plasticity ◽  
Orbital Prefrontal Cortex

Comparing phasic dopamine dynamics in the striatum, nucleus accumbens, amygdala, and medial prefrontal cortex

Synapse ◽  
2018 ◽  
Vol 73 (2) ◽  
pp. e22074 ◽  
Author(s):  
Zade R. Holloway ◽  
Timothy G. Freels ◽  
Josiah F. Comstock ◽  
Hunter G. Nolen ◽  
Helen J. Sable ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Medial Prefrontal Cortex

scholarly journals Non-psychostimulant drugs of abuse and anxiogenic drugs activate with differential selectivity dopamine transmission in the nucleus accumbens and in the medial prefrontal cortex of the rat

1996 ◽  
Vol 127 (3) ◽  
pp. 289-290
Author(s):  
Valentina Bassareo ◽  
Gianluigi Tanda ◽  
Paola Petromilli ◽  
Corrado Giua ◽  
Gaetano Di Chiara
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Medial Prefrontal Cortex ◽  
Drugs Of Abuse ◽  
Dopamine Transmission ◽  
Differential Selectivity ◽  
Anxiogenic Drugs

Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation

2011 ◽  
Vol 217 (2) ◽  
pp. 337-351 ◽  
Author(s):  
Yu-Chun Wang ◽  
Ue-Cheung Ho ◽  
Meng-Ching Ko ◽  
Chun-Chieh Liao ◽  
Li-Jen Lee
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Social Isolation ◽  
Medial Prefrontal Cortex ◽  
Basolateral Amygdala

scholarly journals Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens

2022 ◽  
Author(s):  
Imre Kalló ◽  
Azar Omrani ◽  
Frank J. Meye ◽  
Han de Jong ◽  
Zsolt Liposits ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Medial Prefrontal Cortex ◽  
Fluorescent Protein ◽  
Yellow Fluorescent Protein ◽  
Dopamine Neurons ◽  
Regulatory Processes ◽  
Ventral Tegmental ◽  
Shell Part

AbstractOrexin neurons are involved in homeostatic regulatory processes, including arousal and feeding, and provide a major input from the hypothalamus to the ventral tegmental area (VTA) of the midbrain. VTA neurons are a central hub processing reward and motivation and target the medial prefrontal cortex (mPFC) and the shell part of nucleus accumbens (NAcs). We investigated whether subpopulations of dopamine (DA) neurons in the VTA projecting either to the mPFC or the medial division of shell part of nucleus accumbens (mNAcs) receive differential input from orexin neurons and whether orexin exerts differential electrophysiological effects upon these cells. VTA neurons projecting to the mPFC or the mNAcs were traced retrogradely by Cav2-Cre virus and identified by expression of yellow fluorescent protein (YFP). Immunocytochemical analysis showed that a higher proportion of all orexin-innervated DA neurons projected to the mNAcs (34.5%) than to the mPFC (5.2%). Of all sampled VTA neurons projecting either to the mPFC or mNAcs, the dopaminergic (68.3 vs. 79.6%) and orexin-innervated DA neurons (68.9 vs. 64.4%) represented the major phenotype. Whole-cell current clamp recordings were obtained from fluorescently labeled neurons in slices during baseline periods and bath application of orexin A. Orexin similarly increased the firing rate of VTA dopamine neurons projecting to mNAcs (1.99 ± 0.61 Hz to 2.53 ± 0.72 Hz) and mPFC (0.40 ± 0.22 Hz to 1.45 ± 0.56 Hz). Thus, the hypothalamic orexin system targets mNAcs and to a lesser extent mPFC-projecting dopaminergic neurons of the VTA and exerts facilitatory effects on both clusters of dopamine neurons.

scholarly journals Optogenetic manipulation of Ventral Tegmental Area (VTA) Neurons that project to the Nucleus Accumbens (NAc) and medial Prefrontal Cortex (mPFC)

2012 ◽  
Author(s):  
Jessica Walsh ◽  
Jessica Walsh* ◽  
Dipesh Chaudhury* ◽  
Allyson Friedman ◽  
Barbara Juarez ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Medial Prefrontal Cortex ◽  
Ventral Tegmental
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