Goshajinkigan increases peripheral capillary diameter in non‐diabetic and diabetic mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

P1191 Recombinant adeno-associated virus vector-mediated human VEGF165 gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mice

European Heart Journal ◽

10.1016/s0195-668x(03)94483-6 ◽

2003 ◽

Vol 24 (5) ◽

pp. 222

Author(s):

B DEODATO

Keyword(s):

Wound Healing ◽

Gene Transfer ◽

Virus Vector ◽

Diabetic Mice ◽

Adeno Associated Virus ◽

Genetically Diabetic Mice

PROTEIN SYNTHESIS AND INSULIN RELEASE IN MICRODISSECTED ISLETS OF STEROID DIABETIC MICE

Acta Endocrinologica ◽

10.1530/acta.0.080s039 ◽

1975 ◽

Vol 80 (1_Suppla) ◽

pp. S39

Author(s):

K.-G. Petersen ◽

B. Kröncke

Keyword(s):

Protein Synthesis ◽

Insulin Release ◽

Diabetic Mice

Inhibition of cardiac dysfunction in diabetic mice by treatment with brain natriuretic peptide

Endocrine Abstracts ◽

10.1530/endoabs.35.oc11.1 ◽

2014 ◽

Author(s):

Marek Jankowski ◽

Eric Plante ◽

Jolanta Gutkowska

Keyword(s):

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Cardiac Dysfunction ◽

Diabetic Mice

Stable analogues of the dual agonist dogfish glucagon show better therapeutic potential than exendin-4 in diet induced obese diabetic mice

Endocrine Abstracts ◽

10.1530/endoabs.37.gp.15.05 ◽

2015 ◽

Author(s):

Finbarr P M O'Harte ◽

Ming T Ng ◽

J Michael Conlon ◽

Peter R Flatt

Keyword(s):

Therapeutic Potential ◽

Diabetic Mice ◽

Dual Agonist