Toxicity of thallium on isolated rat liver mitochondria: The role of oxidative stress and MPT pore opening

2013 ◽  
Vol 30 (2) ◽  
pp. 232-241 ◽  
Author(s):  
M R Eskandari ◽  
Vida Mashayekhi ◽  
Majid Aslani ◽  
Mir-Jamal Hosseini
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Pore Opening ◽  
Isolated Rat

The role of metal ions in the uptake of aspartate aminotransferase and malate dehydrogenase into isolated rat liver mitochondria in vitro

FEBS Letters ◽  
1985 ◽  
Vol 189 (2) ◽  
pp. 235-240 ◽  
Author(s):  
S. Passarella ◽  
E. Marra ◽  
A. Atlante ◽  
S. Doonan ◽  
E. Quagliariello
Keyword(s):  
Metal Ions ◽  
Malate Dehydrogenase ◽  
Rat Liver ◽  
Aspartate Aminotransferase ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Isolated Rat

Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition

2004 ◽  
Vol 286 (1) ◽  
pp. H39-H46 ◽  
Author(s):  
Paul S. Brookes ◽  
Victor M. Darley-Usmar
Keyword(s):  
Superoxide Dismutase ◽  
Cytochrome C ◽  
Rat Liver ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Ptp Opening ◽  
Isolated Rat

The mitochondrial permeability transition pore (PTP) is a membrane protein complex assembled and opened in response to Ca2+ and oxidants such as peroxynitrite (ONOO–). Opening the PTP is mechanistically linked to the release of cytochrome c, which participates in downstream apoptotic signaling. However, the molecular basis of the synergistic interactions between oxidants and Ca2+ in promoting the PTP are poorly understood and are addressed in the present study. In isolated rat liver mitochondria, it was found that the timing of the exposure of the isolated rat liver mitochondria to Ca2+ was a critical factor in determining the impact of ONOO– on PTP. Specifically, addition of Ca2+ alone, or ONOO– and then Ca2+, elicited similar low levels of PTP opening, whereas ONOO– alone was ineffective. In contrast, addition of Ca2+ and then ONOO– induced extensive PTP opening and cytochrome c release. Interestingly, Cu/Zn-superoxide dismutase enhanced pore opening through a mechanism independent of its catalytic activity. These data are consistent with a model in which Ca2+ reveals a molecular target that is now reactive with ONOO–. As a test of this hypothesis, tyrosine nitration was determined in mitochondria exposed to ONOO– alone or to Ca2+ and then ONOO–, and mitochondrial membrane proteins were analyzed using proteomics. These studies suggest protein targets revealed by Ca2+ include dehydrogenases and CoA-containing enzymes. These data are discussed in the context of the role of mitochondria, Ca2+, and ONOO– in apoptotic signaling.

Oxaliplatin-induced Oxidative Stress Provokes Toxicity in Isolated Rat Liver Mitochondria

2015 ◽  
Vol 46 (8) ◽  
pp. 597-603 ◽  
Author(s):  
Heena Tabassum ◽  
Mohammad Waseem ◽  
Suhel Parvez ◽  
M. Irfan Qureshi
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Isolated Rat

Protective Effects of Alpha Lipoic Acid Against Arsenic Induced Oxidative Stress in Isolated Rat Liver Mitochondria

2021 ◽  
Author(s):  
Farzan Mozaffarian ◽  
Mohammad Amin Dehghani ◽  
Atefeh Raesi Vanani ◽  
Masoud Mahdavinia
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Lipoic Acid ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Protective Effects ◽  
Alpha Lipoic Acid ◽  
Isolated Rat Liver ◽  
Isolated Rat

scholarly journals Toxicity of Pb2+ on rat liver mitochondria induced by oxidative stress and mitochondrial permeability transition

2017 ◽  
Vol 6 (6) ◽  
pp. 822-830 ◽  
Author(s):  
Long Ma ◽  
Jun-Yi Liu ◽  
Jia-Xin Dong ◽  
Qi Xiao ◽  
Jie Zhao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Mitochondrial Permeability Transition ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Mitochondrial Permeability ◽  
Isolated Rat

Toxicities and mechanisms of Pb2+ on isolated rat liver mitochondria.

Vanadium induces oxidative stress in isolated rat liver mitochondria

2012 ◽  
Vol 211 ◽  
pp. S167 ◽  
Author(s):  
Mir-Jamal Hosseini ◽  
Mir-Jamal Hosseini ◽  
Jalal Pourahmad ◽  
Fatemeh Shaki ◽  
Mahmoud Ghazi-Khansari
Keyword(s):  
Oxidative Stress ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Isolated Rat

Regulation of palmitoylcarnitine oxidation in isolated rat liver mitochondria. Role of the redox state of NAD(H)

1986 ◽  
Vol 875 (2) ◽  
pp. 293-300 ◽  
Author(s):  
P.M. Latipää ◽  
T.T. Kärki ◽  
J.K. Hiltunen ◽  
I.E. Hassinen
Keyword(s):  
Rat Liver ◽  
Redox State ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Isolated Rat
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