P07.08: Atrioventricular septal defect in fetal life-ultrasound diagnostic features, associations, outcome and pathology in a single center series

SummaryA case of a complete atrioventricular septal defect was detected in a 20-week gestation fetus, in whom the ventricular component of the defect was subsequently noted to close spontaneously with advancing gestational age. The antenatal and postnatal findings are discussed.

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Partial atrioventricular septal defect in the fetus: diagnostic features and associations in a multicenter series of 30 cases

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.7317 ◽

2009 ◽

Vol 34 (3) ◽

pp. 268-273 ◽

Cited By ~ 3

Author(s):

D. Paladini ◽

P. Volpe ◽

G. Sglavo ◽

M. G. Russo ◽

V. De Robertis ◽

...

Keyword(s):

Septal Defect ◽

Atrioventricular Septal Defect ◽

Diagnostic Features

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Atrioventricular Septal Defect with Aortic Arch Obstruction: 17-Years of Single Center Experience

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0033-1354518 ◽

2013 ◽

Vol 61 (S 02) ◽

Author(s):

P Murin ◽

S Sata ◽

N Sinzobahamvya ◽

E Schindler ◽

M Schneider ◽

...

Keyword(s):

Aortic Arch ◽

Septal Defect ◽

Atrioventricular Septal Defect ◽

Single Center ◽

Single Center Experience ◽

Arch Obstruction

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The diagnostic features of atrioventricular septal defect with common atrioventricular junction

Cardiology in the Young ◽

10.1017/s1047951100004613 ◽

1998 ◽

Vol 8 (1) ◽

pp. 33-49 ◽

Cited By ~ 38

Author(s):

Robert H. Anderson ◽

Siew Yen Ho ◽

Sueli Falcao ◽

Luciano Daliento ◽

Michael L. Rigby

Keyword(s):

Septal Defect ◽

Atrioventricular Septal Defect ◽

Diagnostic Features ◽

Atrioventricular Junction

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Complete Atrioventricular Septal Defect: Evolution of Results in a Single Center During 50 Years

The Annals of Thoracic Surgery ◽

10.1016/j.athoracsur.2019.01.020 ◽

2019 ◽

Vol 107 (6) ◽

pp. 1824-1830 ◽

Cited By ~ 2

Author(s):

Riku Airaksinen ◽

Ilkka Mattila ◽

Eero Jokinen ◽

Jukka Salminen ◽

Juha Puntila ◽

...

Keyword(s):

Septal Defect ◽

Atrioventricular Septal Defect ◽

Single Center ◽

Complete Atrioventricular Septal Defect ◽

Defect Evolution ◽

Complete Atrioventricular

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Atrioventricular septal defect in fetal life—a clinicopathological correlation

Cardiology in the Young ◽

10.1017/s1047951100010404 ◽

1991 ◽

Vol 1 (4) ◽

pp. 334-343 ◽

Cited By ~ 9

Author(s):

Andrew C. Cook ◽

Lindsey D. Allan ◽

Robert H. Anderson ◽

Gurleen Sharland ◽

Nuala L. K. Fagg

Keyword(s):

Septal Defect ◽

Fetal Echocardiography ◽

Morphological Characteristics ◽

Atrioventricular Septal Defect ◽

Postnatal Life ◽

Fetal Life ◽

Clinicopathological Correlation ◽

Atrioventricular Septal Defects ◽

Septal Defects ◽

High Incidence

SummaryIn a series of over 7,000 pregnancies referred for fetal echocardiography, atrioventricular septal defects were detected in 103 fetuses, (17% of 594 anomalies). A large proportion (42%) also had isomerism of the atrial appendages, abnormalities in arrangement and morphology of the thoracoabdominal organs, and a high incidence of associated cardiac malformations. When this was associated with abnormalities of rhythm, the fetus often showed signs of intrauterine congestive heart failure; hydrops, pleural effusion and ascites. Those with trisomic karyotypes (predominantly trisomy 21) were associated with usual atrial arrangement and concordant connections of the cardiac segments. Of the 103 fetuses, 53 were examined at autopsy. Extracardiac abnormalities were documented, and detailed morphologic examination and measurements of the heart were made. The ratios of inlet to outlet septal disproportion were not significantly different from those found in postnatal hearts. Again, as in postnatal life, those hearts with common atrioventricular orifice had a greater degree of ‘scooping’ of the ventricular septum compared to those with separate right and left atrioventricular valves. There were no significant differences in these findings in relation to the karyotype of the fetus. There was an increased incidence of ventricular dominance, and also of coarctation or hypoplasia of the aortic arch, in fetal hearts when compared to autopsied hearts obtained in postnatal life. In summary, the distinguishing morphological characteristics of atrioventricular septal defect are present from 16 weeks of gestation.

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The spectrum of fetal cardiac malformations

Cardiology in the Young ◽

10.1017/s1047951100012518 ◽

2001 ◽

Vol 11 (1) ◽

pp. 97-110 ◽

Cited By ~ 4

Author(s):

Andrew C. Cook

Keyword(s):

Septal Defect ◽

Ventricular Outflow Tract ◽

Atrioventricular Septal Defect ◽

Left Ventricular ◽

Fetal Life ◽

Entire Cohort ◽

Cardiac Malformations ◽

Left Ventricular Outflow ◽

Minor Part ◽

A Minor

AbstractIncreasingly, paediatric cardiologists are called upon to diagnose cardiac malformations prenatally. In the main, the types of malformation seen during fetal life will be similar to those documented postnatally, but the frequency with which they are encountered, as well as the views that can be used for diagnosis, will be different. This review aims to describe the anatomic spectrum of malformations seen in 917 fetal hearts examined consecutively following prenatal diagnosis. The distribution of anomalies is illustrated in terms of a simple sweep through the fetal thorax passing from the four-chamber plane to the outflow tracts, and then to more cranial views of the mediastinum. Two-thirds of the anomalies described would have been detectable in the four-chamber plane. Some, such as tricuspid valvar abnormalities, will alter the normal appearances of the four-chambers dramatically. In terms of the overall spectrum, however, such obvious abnormalities only form a minor part of the total number. Others, such as atrioventricular septal defect, will often require closer inspection of intracardiac anatomy, but will make up a large proportion of the entire cohort. Up to one third of the anomalies in the series would have required views more cranial to the four-chamber plane of section. In these, it would have been necessary to examine the nature of the left ventricular outflow tract, the crossing of the two outflows, or else the arterial arches in order to secure detection. In the fetus, these and other planes must be considered by the echocardiographer in order completely to detect and document the entire spectrum of cardiac abnormalities likely to be encountered.

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Reoperations After Repair of Partial Atrioventricular Septal Defect: A 45-Year Single-Center Experience

The Annals of Thoracic Surgery ◽

10.1016/j.athoracsur.2010.01.018 ◽

2010 ◽

Vol 89 (5) ◽

pp. 1352-1359 ◽

Cited By ~ 44

Author(s):

John M. Stulak ◽

Harold M. Burkhart ◽

Joseph A. Dearani ◽

Frank Cetta ◽

Roxann D. Barnes ◽

...

Keyword(s):

Septal Defect ◽

Atrioventricular Septal Defect ◽

Single Center ◽

Single Center Experience

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Spectrum and outcome of atrioventricular septal defect in fetal life

Cardiology in the Young ◽

10.1017/s1047951102000045 ◽

2002 ◽

Vol 12 (1) ◽

pp. 18-26 ◽

Cited By ~ 29

Author(s):

Vlasta Fesslova ◽

Laura Villa ◽

Simona Nava ◽

Chiara Boschetto ◽

Carla Redaelli ◽

...

Keyword(s):

Atrioventricular Block ◽

Septal Defect ◽

Complex Form ◽

Atrioventricular Septal Defect ◽

Favourable Outcome ◽

Trisomy 13 ◽

Chromosomal Anomalies ◽

Fetal Life ◽

Atrioventricular Septal Defects ◽

Left Isomerism

Objectives of the study: to analyse the features and outcomes of different types of atrioventricular septal defects, detected during fetal life, as compared to postnatal data. Material and methods: We analysed retrospectively the data concerning 82 fetuses with atrioventricular septal defect, diagnosed from 19 through 37 weeks gestation with a median of 26 weeks. In 46 cases (56.1%), the diagnosis has been made before the age of 24 weeks. Results: Characteristics of the series – in 44 fetuses the atrioventricular septal defect was not associated with other cardiac anomalies, while 38 fetuses had a more complex form. Chromosomal anomalies were present in 33 of the fetuses (40.2%), more frequently in cases without associated intracardiac defects (56.8%). Trisomy 21 occurred in just over one quarter the series, and in 43.2% of cases without associated defects. In addition, 11% of fetuses had trisomy 18, and one had trisomy 13. Extracardiac anomalies were present in 12 of the fetuses (14.6%), more frequently in cases without associated abnormalities. Of fetuses with more complex defects, 46.4% had hypoplasia of the left ventricle and aorta. Complete atrioventricular block was present in 10 of the fetuses (12.2%), mainly in fetuses with other malformations, and particularly with left isomerism. Recurrence of congenital heart disease was observed in 5 of the fetuses (6.1%). Outcome: In 25 instances (30.5%) the parents opted for termination of pregnancy. Of 57 cases that continued through pregnancy, 9 fetuses died prior to term (15.8%), 32 died postnatally (56.13%) and only 16 fetuses (28.1%) survived. Overall, the mortality was higher in cases with associated malformations, in those with heart failure or those with atrioventricular block. Cardiac surgery was performed in 19 infants, with 5 dying postoperatively, and one late. Conclusions: Our data show a high prevalence of atrioventricular septal defect associated with other malformations when diagnosed during fetal life. This combination is less frequently associated with chromosomal and extracardiac anomalies, but more often with obstructive lesions of the left heart and with atrioventricular block. The association results in a less favourable outcome.

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