scholarly journals VP02.02: No congenital abnormalities with perinatal exposure of aspirin, ibuprofen and paracetamol: a safety study using whole embryo culture system

2021 ◽  
Vol 58 (S1) ◽  
pp. 96-96
Author(s):  
S. Moungmaithong ◽  
B. Leung ◽  
P. Chaemsaithong ◽  
T. Leung ◽  
C. Wang ◽  
...  
Keyword(s):  
Embryo Culture ◽  
Culture System ◽  
Congenital Abnormalities ◽  
Perinatal Exposure ◽  
Safety Study ◽  
Whole Embryo Culture

The method of chicken whole embryo culture using the eggshell windowing, surrogate eggshell and ex ovo culture system

2018 ◽  
Vol 59 (2) ◽  
pp. 240-244 ◽  
Author(s):  
M. Farzaneh ◽  
F. Attari ◽  
S. E. Khoshnam ◽  
P. E. Mozdziak
Keyword(s):  
Embryo Culture ◽  
Culture System ◽  
Whole Embryo Culture

scholarly journals Exogenous Nucleotides Antagonize the Developmental Toxicity of EthanolIn Vitro

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Jie Zhao ◽  
Jia-Xi Zhao ◽  
Ya-Jun Xu
Keyword(s):  
Birth Defects ◽  
Embryo Culture ◽  
Culture System ◽  
Growth Parameters ◽  
Developmental Toxicity ◽  
Micromass Culture ◽  
Protective Effects ◽  
Whole Embryo Culture ◽  
Proliferation And Differentiation

The objective of this study was to assess whether nucleotides supplementationin vitrocould suppress ethanol-induced developmental toxicity in mouse. The models of whole embryo culture (WEC) and midbrain (MB) cell micromass culture were used in this study. In WEC system, exposure to 4.0 mg/mL ethanol for 48 h yielded various developmental malformations of the mice embryos. Nucleotides supplementation (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) improved the growth parameters to some extent, and the protective effects peaked at 4.00 mg/L. In MB cell micromass culture system, exposure to 4.0 mg/mL ethanol for 5 days resulted in suppression of proliferation and differentiation. Supplementation of nucleotides (0.16, 0.80, 4.00, 20.00, and 100.00 mg/L) showed some protective effects, which peaked at 4.00 mg/L, too. The present research indicated that nucleotides supplementation might be of some benefit in the prevention of ethanol-induced birth defects; however, appropriate dosage requires attention.

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