Computational studies of DNA repair: Insights into the function of monofunctional DNA glycosylases in the base excision repair pathway

2020 ◽  
Vol 10 (5) ◽  
Author(s):  
Rajwinder Kaur ◽  
Dylan J. Nikkel ◽  
Stacey D. Wetmore
Keyword(s):  
Dna Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Computational Studies ◽  
Dna Glycosylases ◽  
Repair Pathway ◽  
Base Excision Repair Pathway ◽  
Base Excision

scholarly journals The DNA repair protein NBS1 influences the base excision repair pathway

2009 ◽  
Vol 30 (3) ◽  
pp. 408-415 ◽  
Author(s):  
D. Sagan ◽  
R. Muller ◽  
C. Kroger ◽  
A. Hematulin ◽  
S. Mortl ◽  
...  
Keyword(s):  
Dna Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Repair Pathway ◽  
Base Excision Repair Pathway ◽  
Repair Protein ◽  
Dna Repair Protein ◽  
Base Excision

scholarly journals Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

FEBS Letters ◽  
1999 ◽  
Vol 450 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Hagai Offer ◽  
Roland Wolkowicz ◽  
Devorah Matas ◽  
Sara Blumenstein ◽  
Zvi Livneh ◽  
...  
Keyword(s):  
Dna Repair ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Repair Pathway ◽  
Base Excision Repair Pathway ◽  
Direct Involvement ◽  
Base Excision

scholarly journals Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway

2019 ◽  
Vol 44 (9) ◽  
pp. 765-781 ◽  
Author(s):  
Elwood A. Mullins ◽  
Alyssa A. Rodriguez ◽  
Noah P. Bradley ◽  
Brandt F. Eichman
Keyword(s):  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Glycosylases ◽  
Repair Pathway ◽  
Base Excision Repair Pathway ◽  
Base Excision

scholarly journals DNA repair in plant mitochondria – a complete base excision repair pathway in potato tuber mitochondria

2018 ◽  
Vol 166 (2) ◽  
pp. 494-512 ◽  
Author(s):  
Beatriz Ferrando ◽  
Ana L.D.M. Furlanetto ◽  
Ricardo Gredilla ◽  
Jesper F. Havelund ◽  
Kim H. Hebelstrup ◽  
...  
Keyword(s):  
Dna Repair ◽  
Potato Tuber ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Plant Mitochondria ◽  
Repair Pathway ◽  
Base Excision Repair Pathway ◽  
Base Excision

scholarly journals Effect of DNA Glycosylases OGG1 and Neil1 on Oxidized G-Rich Motif in the KRAS Promoter

2021 ◽  
Vol 22 (3) ◽  
pp. 1137
Author(s):  
Annalisa Ferino ◽  
Luigi E. Xodo
Keyword(s):  
Oxidative Stress ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Start Site ◽  
Dna Glycosylases ◽  
Repair Pathway ◽  
Transcription Start ◽  
G Quadruplex ◽  
Base Excision ◽  
Regulatory Functions

The promoter of the Kirsten ras (KRAS) proto-oncogene contains, upstream of the transcription start site, a quadruplex-forming motif called 32R with regulatory functions. As guanine under oxidative stress can be oxidized to 8-oxoguanine (8OG), we investigated the capacity of glycosylases 8-oxoguanine glycosylase (OGG1) and endonuclease VIII-like 1 (Neil1) to excise 8OG from 32R, either in duplex or G-quadruplex (G4) conformation. We found that OGG1 efficiently excised 8OG from oxidized 32R in duplex but not in G4 conformation. By contrast, glycosylase Neil1 showed more activity on the G4 than the duplex conformation. We also found that the excising activity of Neil1 on folded 32R depended on G4 topology. Our data suggest that Neil1, besides being involved in base excision repair pathway (BER), could play a role on KRAS transcription.

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