AbstractIn the present work, a novel approach was proposed to optimize the teleportation cost in Distributed Quantum Circuits (DQCs) by applying a new approach. To overcome the difficulty with keeping a large number of qubits next to each other, DQCs, as a well-known solution, have always been employed. In a distributed quantum system, qubits are transferred from a subsystem to another subsystem by a quantum protocol such as teleportation. First, we proposed a heuristic approach through which we could replace the equivalent circuits in the initial quantum circuit. Then, we used a genetic algorithm to partition the placement of qubits so that the number of teleportations could be optimized for the communications of a DQC. Finally, results showed that the proposed approach could impressively work.